Our recently formed laboratory focuses on the development of experimental models of cardiovascular disease in order to obtain knowledge on the mechanisms underlying the origin and progression of these diseases and to test the efficacy of novel interventions. Our studies span the molecular origins of disease and their manifestations at the macro anatomical and physiological levels. Our evaluation of experimental animal models makes use of advanced imaging techniques that can also be applied to humans, strengthening the translational potential of our research. To exploit this potential, we work on multi-disciplinary programs in close collaboration with hospitals and clinical researchers.
One of our major interests is cardioprotection during myocardial infarction (MI). In the initial phase of this project we are establishing different models of MI in rodents and large animals. These models will first be used to study the mechanisms underlying the beneficial effects of various cardioprotective strategies (mainly those related to the modulation of the adrenergic system). Once the advanced imaging equipment is fully installed at the CNIC, it will serve as a translational tool to confirm the mechanistic findings of the bench studies.
In our first year, we have already established collaborations with several hospitals and emergency medical services to carry out the imaging examinations for proof-of-principle clinical trials; and we are also participating in the European Commission funded HYPERImage project for the development of imaging technologies.
Borja Ibáñez qualified in Medicine in 1999 from the Universidad Complutense de Madrid, and was awarded his PhD in Medicine by the Universidad Autónoma de Madrid in 2009. He successfully applied in the first call for the Cardiology residency at the Fundación Jiménez Díaz, Madrid (2000-2005), where he undertook clinical research, working principally with invasive imaging techniques for the study of atherothrombotic disease. After completing his training in clinical cardiology, he trained in basic and translational research with Professors Juan J. Badimon and Valentín Fuster at the Mount Sinai School of Medicine, New York (2005-2008). During this period he worked on the two areas of interest that form the focus of his research at the CNIC. On his return to Madrid, he joined the Department of Cardiovascular Imaging at the CNIC, and he combines his research with his clinical work at the Hospital Clínico San Carlos de Madrid in interventional cardiology and coronary care.