- Jose Antonio Enríquez Domínguez
- Program Coordinator
José Antonio Enríquez graduated in Biochemistry and
Molecular Biology at the Universidad Autónoma de Madrid and
obtained his PhD from the Universidad de Zaragoza in 1992.
His thesis examined various aspects of mitochondrial DNA biogenesis.
From 1993 to 1997 he worked with G. Attardi at the California Institute
of Technology, where he studied the pathogenic action of mutant mitochondrial
tRNAs. His work in this period contributed to define the molecular
mechanism underlying this phenomenon, and helped to establish the general
methodologies for studying mitochondrial tRNAs. These methodologies
have found application in studies of mitochondrial biogenesis and in
the analysis of mtDNA-linked diseases. José Antonio established
his own laboratory on his return to the Universidad de Zaragoza,
where he became a Full Professor in 2007. His group has made important
contributions to the understanding of mitochondrial biogenesis and
bioenergetics, the role of mitochondria in apoptosis, the structure,
formation and regulation of the respiratory chain, and the pathological
consequences of altered mitochondrial function in human disease. He
recently established a possible explanation for the phenotypes associated
with common mouse mtDNA variants affecting ROS production. He joined
the CNIC in 2009, where his work focuses on the molecular processes
underlying the involvement of mitochondrial dysfunction in cardiovascular
disease and ischemic processes.