Home Excelencia Severo Ochoa
Selected papers
Martin D, Pantoja C, Miñán AF, Valdes-Quezada C, Moltó E, Matesanz F, Bogdanović O, de la Calle-Mustienes E, Domínguez O, Taher L, Furlan-Magaril M, Alcina A, Cañón S, Fedetz M, Blasco MA, Pereira PS, Ovcharenko I, Recillas-Targa F, Montoliu L, Manzanares M, Guigó R, Serrano M, Casares F, Gómez-Skarmeta JL. Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 18:708-14
Cañon S, Fernandez-Tresguerres B, Manzanares M. Pluripotency and lineages in the mammalian blastocyst: An evolutionary view. Cell Cycle (2011) 10:1731-8
Pernaute B, Spruce T, Rodriguez TA, Manzanares M. MiRNA-mediated regulation of cell signaling and homeostasis in the early mouse embryo. Cell Cycle (2011) 10:584-91
Tena JJ, Alonso ME, de la Calle-Mustienes E, Splinter E, de Laat W, Manzanares M, Gómez-Skarmeta JL. An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation. Nat Commun (2011) 2:310
Fernandez-Tresguerres B, Cañon S, Rayon T, Pernaute B, Crespo M, Torroja C, Manzanares M. Evolution of the mammalian embryonic pluripotency gene regulatory network. Proc Natl Acad Sci U S A (2010) 107:19955-60
Pittman AM, Naranjo S, Jalava SE, Twiss P, Ma Y, Olver B, Lloyd A, Vijayakrishnan Y, Qureshi M, Broderick P, van Wezel T, Morreau H, Tuupanen S, Aaltonen LA, Alonso ME, Manzanares M, Gavilan A, Visakorpi T, Gomez-Skarmeta JL, Houlston RS. Allelic Variation at the 8q23.3 Colorectal Cancer Risk Locus Functions as a Cis-Acting Regulator of EIF3H. Plos Genet (2010) 6:e1001126
Kouwenhoven EN, van Heeringen SJ, Tena JJ, Oti M, Dutilh BE, Alonso ME, de la Calle-Mustienes E, Smeenk L, Rinne T, Parsaulian L, Bolat E, Jurgelenaite R, Huynen MA, Hoischen A, Veltman JA, Brunner HG, Roscioli T, Oates E, Wilson M, Manzanares M, Gómez-Skarmeta JL, Stunnenberg HG, Lohrum M, van Bokhoven H, Zhou H. Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. Plos Genet (2010) 6:e1001065
Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA. An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Dev Cell (2010) 19:207-19
Ragvin A, Moro E, Fredman D, Navratilova P, Drivenes Ø, Engström PG, Alonso ME, Mustienes Ede L, Skarmeta JL, Tavares MJ, Casares F, Manzanares M, van Heyningen V, Molven A, Njølstad PR, Argenton F, Lenhard B, Becker TS. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci U S A (2010) 107:778-80
Pernaute B, Canon S, Crespo M, Fernandez-Tresguerres B, Rayon T, Manzanares M. Comparison of extraembryonic expression of Eomes and Cdx2 in pregastrulation chick and mouse embryo unveils regulatory changes along evolution. Dev Dyn (2010) 239:620-9
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Miguel Manzanares
  • Miguel Manzanares Fourcade
  • Program Coordinator
  • Ext.3109

Miguel Manzanares obtained his degree in Biology from the Universidad Autónoma de Madrid (UAM) in 1988, and his PhD from the same university in 1993. During his PhD studies in the group of Rafael Garesse (Department of Biochemistry, UAM), Miguel compared the genetic mechanisms of embryonic segmentation in crustaceans and insects. He subsequently worked for six years in Robb Krumlauf’s group at the National Institute of Medical Research in London, where he investigated the role of Hox genes in the patterning of the vertebrate nervous system, as well as studying the evolution of the neural crest. On his return to Madrid Miguel joined Angela Nieto’s group at the Instituto Cajal (CSIC), where he worked on the role of Snail genes in the patterning and evolution of the neural crest. In 2001 he established his own research group at the Instituto de Investigaciones Biomédicas (CSIC-UAM), devoted to the study of evolutionary novelties and the functional analysis of genome regulation and evolution. He was elected member of the EMBO-YIP programme in 2003, and joined the CNIC in 2007.