| Menéndez-Gutiérrez MP, Rőszer T, Ricote M. Biology and therapeutic applications of peroxisome proliferator-activated receptors. Curr Top Med Chem (2012) 12:548-84 |
| Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi J, Dopazo J, Oresic M, Ricote M, Vidal-Puig A. Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice. Diabetes (2011) 60:797-809 |
| Roszer T, Menendez-Gutierrez MP, Lefterova MI, Alameda D, Nunez V, Lazar MA, Fischer T, Ricote M. Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor {gamma} or Retinoid X Receptor {alpha} Deficiency. J Immunol (2011) 186:621-31 |
| Núñez V, Alameda D, Rico D, Mota R, Gonzalo P, Cedenilla M, Fischer T, Boscá L, Glass CK, Arroyo AG, Ricote M. Retinoid X receptor {alpha} controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A (2010) 107:10626-31 |
| Fuentes L, Roszer T, Ricote M. Inflammatory Mediators and Insulin Resistance in Obesity: Role of Nuclear Receptor Signaling in Macrophages. Mediators Inflamm (2010) 2010:219583 |
| Roszer T, Ricote M. PPARs in the renal regulation of systemic blood pressure. Ppar Res (2010) 2010:698730 |
| Prieur X, Roszer T, Ricote M. Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome. Biochim Biophys Acta (2010) 1801:327-37 |
| Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 117:1658-69 |
| Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass CK. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol (2006) 80:850-61 |
| Cunard R, Eto Y, Muljadi JT, Glass CK, Kelly CJ, Ricote M. Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma. J Immunol (2004) 172:7530-6 |
- Mercedes Ricote Pacheco
- Junior group leader
- Ext.3306
Mercedes Ricote graduated in Biology from the Universidad Complutense de Madrid (1985). She began her scientific career in the Endocrinology Department at the Hospital Ramón y Cajal, Madrid, where she investigated regulatory systems involved in the pathogenesis of essential hypertension. In 1994 she obtained her PhD in Biochemistry and Molecular Biology, and afterwards moved to the Burnham Institute, San Diego, where she studied the regulation of gene expression in colon tumors. Continuing her interest in nuclear receptor signaling and cardiovascular research, in 1996 she joined Dr. C. Glass’s laboratory at the University of California, San Diego (UCSD). Her studies there focused on the role of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in the regulation of macrophage development and function. She was primarily responsible for the discovery that PPAR-gamma and its ligands inhibit macrophage activation. The Nature article reporting these findings has been cited more than 1600 times, highlighting the importance of this discovery.
In 2000, Dr. Ricote was appointed as an Assistant Research Scientist in the Department of Cellular and Molecular Medicine, UCSD, where she extended her studies to explore the potential role of PPARs in innate and adaptive immunity. Mercedes joined the CNIC in 2004.
© 2013 Centro Nacional de Investigaciones Cardiovasculares