Regulatory molecules of inflammatory processes - Publications

Overview Collaborations Personnel Publications

Selected papers

Lamana A, Martin P, de la Fuente H, Martinez-Muñoz L, Cruz-Adalia A, Ramirez-Huesca M, Escribano C, Gollmer K, Mellado M, Stein JV, Rodriguez-Fernandez JL, Sanchez-Madrid F, Del Hoyo GM. CD69 Modulates Sphingosine-1-Phosphate-Induced Migration of Skin Dendritic Cells. J Invest Dermatol (2011) 131:1503-12

Martín P, Sánchez-Madrid F. CD69: An Unexpected Regulator of TH17 Cell-Driven Inflammatory Responses. Science Signaling (2011) 4:pe14

Cruz-Adalia A, Jiménez-Borreguero LJ, Ramírez-Huesca M, Chico-Calero I, Barreiro O, López-Conesa E, Fresno M, Sánchez-Madrid F, Martín P. CD69 Limits the Severity of Cardiomyopathy After Autoimmune Myocarditis. Circulation (2010) 122:1396-404

Martín P, Gómez M, Lamana A, Cruz-Adalia A, Ramírez-Huesca M, Ursa MA, Yáñez-Mo M, Sánchez-Madrid F. CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation. Mol Cell Biol (2010) 30:4877-89

Martín P, Gómez M, Lamana A, Marín AM, Cortés JR, Ramírez-Huesca M, Barreiro O, López-Romero P, Gutiérrez-Vázquez C, de la Fuente H, Cruz-Adalia A, Sánchez-Madrid F. The leukocyte activation antigen CD69 limits allergic asthma and skin contact hypersensitivity. J Allergy Clin Immun (2010) 126:355-65

Barreiro O, Martin P, Gonzalez-Amaro R, Sanchez-Madrid F. Molecular cues guiding inflammatory responses. Cardiovasc Res (2010) 86:174-82

Martin P, Diaz-Meco MT, Moscat J. The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. Embo J (2006) 25:3524-33

Martin P, Villares R, Rodriguez-Mascarenhas S, Zaballos A, Leitges M, Kovac J, Sizing I, Rennert P, Márquez G, Martínez-A C, Diaz-Meco MT, Moscat J. Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. Proc Natl Acad Sci U S A (2005) 102:9866-71

Lafuente MJ, Martin P, Garcia-Cao I, Diaz-Meco MT, Serrano M, Moscat J. Regulation of mature T lymphocyte proliferation and differentiation by Par-4. Embo J (2003) 22:4689-98

Martin P, Duran A, Minguet S, Gaspar ML, Diaz-Meco MT, Rennert P, Leitges M, Moscat J. Role of zeta PKC in B-cell signaling and function. Embo J (2002) 21:4049-57

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Pilar Martín
Junior group leader
Ext.2009

María Pilar Martín Fernández (Madrid, 1973) has a degree in Biological Sciences at the Complutense University of Madrid (1996), where she did her doctoral thesis in immunology (2001). During her PhD, under the supervision of C. Ardavín, she studied the immune response against the Mouse Mammary Tumour Virus (MMTV) in collaboration with Dr. Hans Acha-Orbea from Ludwig Institute of Cancer Research (Laussane, Switzerland). This work was carried out in parallel to the characterization of the different Dendritic cells subpopulations in mice and the study of their origin/lineage. In the postdoctoral stage she moved to the laboratory of Dr. J. Moscat at the Centro de Biología Molecular “Severo Ochoa” where she obtained an I3P postdoctoral contract from CSIC. Her work focused in the characterization of , the inhibitor Par-4 and the deficient mice for the atypical protein kinase PKC? scaffold protein p62. The development of chronic inflammatory disease animal models (allergic asthma, ulcerative colitis, rheumatoid arthritis, EAE…) in collaboration with Dr. Paul Rennert from Biogen Inc, (Cambridge, Boston, USA), signalling is necessary for IL-4 activation pathway helped to show that PKC? (Jak-1/Stat-6) in vitro and in vivo, and therefore, essential for the differentiation of Th2 cells. In january 2007, she joined to Dr. F. Sánchez-Madrid (Hospital Universitario de la Princesa) lab with a Ramón y Cajal contract and later she moved to the Dept. Vascular Biology and Inflammation (CNIC) as a Junior I Researcher, where she develops and independent line of investigation focusing on the study of regulatory molecules in inflammatory processes.