Our laboratory is interested in various aspects of the inflammatory response. We are developing techniques based on multichannel fluorescence intravital microscopy to visualize the molecular and cellular phenomena that occur within the inflamed vasculature. We are also interested in understanding the mechanisms by which leukocyte production and release during inflammation modulates homeostatic processes.
Imaging inflammation: Leukocytes and platelets are recruited to inflamed vessels via adhesion receptors, chemokines and cytokines. During this process, leukocytes redistribute surface receptors to discrete domains, each of which can mediate interactions with circulating platelets and erythrocytes. These interactions can lead to an excessive activation of the leukocyte, which in turn releases toxic mediators that damage the surrounding endothelium. We want to understand the biology of these interactions, including how they lead to the formation of polarized leukocyte domains, the identity of the receptors that mediate them and their consequences in inflammatory processes. We are particularly interested in understanding the potential contribution of these interactions to vascular injury under atherogenic conditions.
Control of leukocyte production and release: We aim to dissect the links between inflammation and alterations in the bone marrow niches, the home of hematopoietic stem cells and their differentiated progeny. We are addressing this through the use of gene-targeted mouse models with alterations in the immune and hematopoietic systems. Our goal is to define the signals that these biological systems use to communicate with each other and to understand how this is regulated and altered during disease.
Andrés Hidalgo se licenció en CC. Biológicas por la Universidad Autónoma de Madrid en 1993, y se doctoró por la misma universidad en 1999 tras trabajar en control de la adhesión hematopoiética, en el laboratorio del Dr. Joaquín Teixidó (Centro de Investigaciones BIológicas, Madrid). En 2000 se mudó a Nueva York, donde se centró en entender los procesos de migración de leucocitos y células madre hematopoiéticas, así como procesos inflamatorios, en el laboratorio del Dr. Paul Frenette (Mount Sinai School of Medicine). Tras conseguir un contrato de reincorporación Ramón y Cajal, se incorpora como Investigador Junior II en el departamento de Aterotrombosis e Imagen Cardiovascular.del CNIC en 2008.