New insights into cell & tissue interactions
in cardiovascular development and disease
Program
DAY 1, Thursday, September 23
| 09:00-09:30 | Registration |
|---|---|
| 09:30-09:45 | Welcome |
Session I
Non-myocardial tissues in heart development and disease (I): Cardiac valves
Chair: José María Perez Pomares
| 09:45-10:30 | Ramón Muñoz-Chápuli, Universidad de Málaga, Spain "Epicardial-mesenchymal transformation and developmental fate of the epicardium-derived cells" |
|---|---|
| 10:30-11:00 | Joy Lincoln, Leonard M. Miller School of Medicine University of Miami, USA "The role of Sox9 and Scleraxis is heart valve remodeling and disease" |
| 11:00-11:15 | Luis Luna-Zurita (Selected presentation), Centro Nacional de Investigaciones Cardiovasculares, Spain "Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation" |
| 11:15-11:45 | Coffee break |
| 11:45-12:00 | Eva Garrido-Martín (Selected presentation), Centro de Investigaciones Biológicas, Spain "The endothelial TGF-β receptor alk1 is involved in the angiogenic response after a vascular injury and under hypoxia" |
| 12:00-12:30 | José Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares, Spain "Notch signaling in the cardiac valves" |
| 12:30-14:00 | Lunch + Posters |
Session II
Non-myocardial tissues in heart development and disease (II):
Coronaries & ischemic disease
Chair: David García-Dorado
| 14:00-14:30 | William Pu, Children's Hospital Boston, USA "Epicardial function in the developing and adult heart" |
|---|---|
| 14:30-14:45 | Gonzalo del Monte (Selected presentation), Centro Nacional de Investigaciones Cardiovasculares, Spain "Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis" |
| 14:45-15:15 | José María. Pérez-Pomares, Universidad de Málaga, Spain "Signalling coordination during epicardial embryonic development and differentiation" |
| 15:15-15:45 | David García-Dorado, Hospital Universitari Vall d'Hebron, Barcelona "Role of Connexin43 in cell death and cardioprotective signaling during myocardial ischemia-reperfusion" |
| 15:45-16:15 | Coffe break |
Session III
Genetics of vascular development, patterning and remodelling:
endothelial heterogeneity and the onset of blood vessel dysfunction
Chair: Elizabetta Dejana
| 16:15-16:45 | Vicente Andrés, Centro Nacional de Investigaciones Cardiovasculares, Spain "Molecular mechanisms underlying regional variability in the susceptibility to atherosclerosis" |
|---|---|
| 16:45-17:00 | Helen Phillips (Selected presentation), University of Newcastle, UK "Investigating the role of Rho kinase in the Epicardium and Myocardium" |
| 17:00-17:30 | Elizabetta Dejana, IFOM-IEO, Italy "The role of canonic Wnt signaling in vascular development and specification" |
| 17:30-17:45 | Coffee Break |
| 17:45-18:00 | Tania Papoutsi (Selected presentation), Newcastle University, UK "Intra- and extra-cardiac contribution of JNK during heart cell specification and cardiac development" |
| 18:00-18:30 | Mauro Giacca, ICGEB Trieste Component, Italy "Searching for genes that induce myocardial protection, myocardial repair or neoangiogenesis by in vivo gene transfer using AAV vectors" |
| 21:00 | Dinner with speakers |
DAY 2, Friday, September 24
Session IV
Cell migration and differentiation in the developing outflow tract
Chair: Deborah Henderson
| 09:00-09:30 | Robert Kelly, Université de la Méditerranée, France "Regulators of second heart field development" |
|---|---|
| 09:30-09:45 | Mohammed Sameer Rana (Selected presentation), Univ. of Amsterdam, The Netherlands "Combinatorial requirements for T-box factors during development of the arterial pole of the heart" |
| 09:45-10:15 | Deborah Henderson, Institute of Human Genetics University Newcastle, UK "Cell and tissue polarity during outflow morphogenesis" |
| 10:15-10:45 | Marja W. Wessels, Erasmus Medical Center, The Netherlands "Genetics of human cardiac outflowtract anomalies" |
| 10:45-11:15 | Coffee break |
Session V
Genetic analysis of myocardial diversification and maturation:
building cardiac chambers
Chair: José Xavier Nieto
| 11:15-11:45 | José Xavier-Neto, INCOR-Universidad de São Paulo, Brasil "Retinoic acid and VEGF delay smooth muscle relative to endothelial differentiation to coordinate inner and outer coronary vessel wall morphogenesis" |
|---|---|
| 11:45-12:15 | Vincent Christoffels, AMC-University of Amsterdam, Netherlands "Role of T-box transcription factors in pacemaker and conduction system development" |
| 12:15-12:30 | Marina Campione (Selected presentation), University of Padova, Italy " Pitx2 is required in the myocardium to determine sinoatrial node function and identity" |
| 12:30-12:45 | Catalina Hernández-Sánchez (Selected presentation), Centro de Investigaciones Biológicas, Spain " Tyrosine Hydroxylase is expressed during early heart development and is required for cardiac chamber formation" |
| 12:45-13:15 | Luis García Guereta, Hospital Universitario La Paz, Spain "Basic knowledge of congenital malformations of cardiac chamber" |
| 13:15-14:30 | Posters and lunch |
Session VI
Novel cell tracing, imaging and tissue engineering
approaches to study cardiac development and disease
Chair: Antoon F. Moorman
| 14:30-15:00 | Miguel Torres, Centro Nacional de Investigaciones Cardiovasculares, Spain "Cell lineage analysis of the developing cardiovascular system" |
|---|---|
| 15:00-15:30 | Antoon F. Moorman, AMC-University of Amsterdam, Netherlands "The Organization of Cardiac Growth" |
| 15:30-15:45 | Gavin D. Richardson (Selected presentation), Durham University, UK " The Identification of Cardiac Stem Cells using Telomerase as a Functional Marker" |
| 15:45-16:00 | Coffee break |
| 16:00-16:30 | Borja Ibañez, Centro Nacional de Investigaciones Cardiovasculares, Spain " Pre-clinical models: Role of imaging in reduction" |
| 16:30-17:00 | Robin Choudhury, John Radcliffe Hospital, University of Oxford, UK "Novel imaging technology: inflammation, molecular imaging and beyond" |
| 17:00 | Concluding remarks and end of meeting |