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    E.g., 07/12/2023
    E.g., 07/12/2023
    Foto de grupo Jacardi
    About the CNIC
    29 Nov 2023
    CNIC and the i+12 Institute participate in the most ambitious EU project to reduce the burden of cardiovascular diseases and diabetes

    CNIC and the i+12 Institute co-lead one of the working groups of this initiative.
    Neuregulin-1 induces changes in actin filaments during ventricular maturation. Actinin staining of a mouse embryo heart reveals a striated actin pattern corresponding to mature trabecular sarcomeres (green). The magnified view shows the differences in luminosity that distinguish the more organized actin filaments of the trabecular myocardium from the less organized compact layer
    Research
    10 Nov 2023
    CIRCULATION RESEARCH: CNIC scientists identify the crucial role of the protein neuregulin-1 in heart development

    Neuregulin-1 (Nrg1) plays an essential role in the transformation of the heart from its delicate primordial structure into the powerful beating mature organ 

    Generación de células dendríticas post-sinápticas. La imagen muestra los contactos intercelulares entre las células dendríticas y los linfocitos T. Células Dendríticas (verde) y los linfocitos T (azul y rosa)
    Research
    26 Oct 2023
    Nature Communications: Spanish scientists identify changes in dendritic cells during the immune response with promising implications for vaccine design

    Scientists at the CNIC and Hospital de la Princesa-UAM have identified profound changes taking place in dendritic cells during antigen presentation to a lymphocyte via intimate contact called an immune synapse
    Research
    2 Oct 2023
    Diabetes Care: Obesity, high blood pressure, and lipid imbalance trigger a progressive loss of energy generation capacity in the heart

    Scientists at the CNIC have discovered that metabolic cardiovascular risk factors diminish the capacity of the heart to use glucose as an energy source
    Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Donald McGrogan y José Luis de la Pompa.
    Research
    5 Jul 2023
    Jama Cardiology: An international team identifies the mutations that cause the most frequent congenital heart defects

    A multicenter study published in JAMA Cardiology and co-led by scientists at Hadassah Medical Center, Sheba Medical Center, and the CNIC could help in the design of future pharmacological treatments for bicuspid aortic valve

    De izda. a dcha.: Gema González, Estefanía Núñez, Sergio Callejas, Juan Carlos Silla, Enrique Lara-Pezzi, Valentín Fuster, Fátima Sánchez Cabo, José Javier Fuster, Ana Dopazo, Borja Ibáñez, Marta Cortés, Alberto Benguría y Antonio Quesada.
    Research
    21 Jun 2023
    European Heart Journal: Atherosclerosis accelerates aging

    A new CNIC study shows that low-grade systemic inflammation triggered by subcinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals
    Vanessa Núñez, Jesús Vázquez, Emilio Camafeita, Ana Paredes, Pablo Hernansanz-Agustín, Mercedes Ricote, Fátima Sánchez Cabo y Fernando Martínez.
    Research
    24 May 2023
    Nature: GLA, the fatty acid that makes the heart function properly after birth

    A study by CNIC researchers published in Nature has found that the omega-6 fatty acid gamma-linolenic acid (GLA), present in breast milk, plays an essential role in ensuring the proper functioning of the heart after birth
    Dr. García Pavía
    Research
    21 May 2023
    NEJM: A Spanish team presents the first pharmacological treatment able to improve cardiac function in stiff-heart syndrome

    The team led by Dr. Pablo García-Pavía, based at the CNIC and Hospital Puerta de Hierro, has published the first study of a drug able to remove amyloid deposits from the heart

    Análisis de muestras humanas y experimentos en animales demuestran que la presencia de mutaciones en el gen p53 en sangre aumenta el riesgo de desarrollar aterosclerosis, la principal causa de enfermedad cardiovascular.
    Research
    16 Jan 2023
    Nature Cardiovascular Research: The 'guardian of the genome' protects against cardiovascular disease

    A CNIC study extends the understanding of how acquired mutations in blood cells act as a new cardiovascular risk factor
    Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
    Research
    23 Dec 2022
    Nature Cell Biology: A CNIC study shows that cells possess 2 mechanisms to allow them to respond to different force ranges

    A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces