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    Dr. Jorge Alegre Cebollada
    About the CNIC
    10 Jun 2021
    Dr Jorge Alegre, named member of the Academia Joven de España

    The principal aim of the AJE, the Spanish Young Academy, is to represent and give a voice to young scientists
    Scheme of a cMyBP-C region in which mutations cause amino-acid changes that alter the mechanical properties of the protein. The positions of the affected amino acids are shown in red.
    Research
    7 Jun 2021
    ACS Nano: CNIC scientists describe a possible disease-causing mechanism in hypertrophic cardiomyopathy

    A team led by Dr. Jorge Alegre-Cebollada has shown, for the first time, an association between hypertrophic cardiomyopathy and mechanical alterations to a component of the contractile machinery of the heart
    About the CNIC
    10 Dec 2020
    The 'ProtMechanics-Live' project, led by Dr. Jorge Alegre, awarded ERC Consolidator funding in the ERC-2020-COG call

    'ProtMechanics-Live' is based on unique expertise in protein mechanics and engineering, biophysics, biochemistry and cardiovascular biology and will allow to investigate protein mechanics for the first time in its functionally relevant physiological context
    Research
    28 Apr 2020
    Nature Communications: CNIC scientists design an experimental mouse model for investigating the mechanical function of proteins in vivo

    CNIC scientists, working with international partners, have developed a new experimental mouse model that allows them to study how cells sense, interpret, and generate mechanical forces
    Dr. Alegre-Cebollada (center), Prof. Julio Fernández (left), and study author Carmen Badilla (right).
    Research
    12 Jan 2018
    Nature Communications: Scientists identify a key mechanism regulating a protein required for muscle and heart function

    Scientists at the CNIC and Columbia University have identified a new mechanism regulating the elasticity of titin, a protein with important roles in the function of skeletal and heart muscle