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    E.g., 25/04/2024
    E.g., 25/04/2024
    The image represent glucose uptake in the brain measured by positron emission tomography in middle-aged individuals with low (top) or high (bottom) sustained cardiovascular risk over 5 years. The colors represent cerebral glucose consumption, with red indicating higher consumption and blue lower consumption
    Research
    31 Aug 2023
    The Lancet Healthy Longevity: Early action to control cardiovascular risk factors preserves brain metabolism

    A study published in The Lancet Healthy Longevity shows that brain metabolism, detected with advanced imaging techniques, declines more sharply in middle-aged people with a sustained high cardiovascular risk over 5 years
    En primer plano: Emilio Camafeita, Rui Benedito y Macarena Fernández; detrás, de izda. a dcha., Ana Dopazo, Jesús Vázquez, Alberto Benguria, Mariya Lytvyn, Severin Muhleder, Sofía Sánchez, Lourdes García.
    Research
    29 May 2023
    Nature Cardiovascular Research: Scientists identify how some angiogenic drugs used to treat cancer and heart disease cause vascular disease

    The new study, published in Nature Cardiovascular Research, will help to select the most effective and safe way to modulate angiogenesis in ischemic tissues or in cancer
    Vanessa Núñez, Jesús Vázquez, Emilio Camafeita, Ana Paredes, Pablo Hernansanz-Agustín, Mercedes Ricote, Fátima Sánchez Cabo y Fernando Martínez.
    Research
    24 May 2023
    Nature: GLA, the fatty acid that makes the heart function properly after birth

    A study by CNIC researchers published in Nature has found that the omega-6 fatty acid gamma-linolenic acid (GLA), present in breast milk, plays an essential role in ensuring the proper functioning of the heart after birth
    Miguel Galán, David Sancho, Stefanie K. Wculek, Annalaura Mastrangelo, Verónica Miguel ,Ignacio Heras-Murillo, Diego Mañanes, José Antonio Enríquez and Andrea Curtabbi.
    Research
    3 Feb 2023
    IMMUNITY: Scientists identify a new therapeutic target in macrophages for the treatment of obesity-related diseases

    The discovery, published in the journal Immunity, identifies a new therapeutic route for conditions associated with obesity and metabolic syndrome, including cardiovascular disease
    Análisis de muestras humanas y experimentos en animales demuestran que la presencia de mutaciones en el gen p53 en sangre aumenta el riesgo de desarrollar aterosclerosis, la principal causa de enfermedad cardiovascular.
    Research
    16 Jan 2023
    Nature Cardiovascular Research: The 'guardian of the genome' protects against cardiovascular disease

    A CNIC study extends the understanding of how acquired mutations in blood cells act as a new cardiovascular risk factor
    Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
    Research
    23 Dec 2022
    Nature Cell Biology: A CNIC study shows that cells possess 2 mechanisms to allow them to respond to different force ranges

    A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces
    Las células senescentes (mostradas por luminiscencia) aparecieron en el hombro de ratón después de la lesión
    Research
    19 Dec 2022
    Nature: Researchers characterize rare, damaged cells that block the functions of their neighbour healthy cells and identify ways to neutralize them and improve tissue regeneration

    The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people and for improving muscle repair in young healthy people
    La figura muestra imágenes mediante resonancia magnética cardíaca (A y B) y tomografía computarizada (C y D) de un corazón en diástole (A y C) y sístole (B y D) para el cálculo de la función de ambos ventrículos. VD: Ventrículo derecho; VI: Ventrículo izquierdo.
    Research
    12 Dec 2022
    European Journal of Heart Failure: A promising drug treatment for patients with pulmonary hypertension associated with heart disease

    The results of the SPHERE-HF study are published in the European Journal of Heart Failure. SPHERE-HF is a multicenter academic clinical trial led by investigators at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona
    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research
    29 Nov 2022
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart
    Research
    3 Nov 2022
    Nature Cardiovascular Research: CNIC scientists identify the cause of arrhythmias and sudden death in Andersen-Tawil syndrome type 1

    CNIC scientists have identified a molecular mechanism that accounts for the arrhythmias, skeletal muscle weakness, and periodic paralysis in patients with this rare disease