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E.g., 07/02/2023
E.g., 07/02/2023
Análisis de muestras humanas y experimentos en animales demuestran que la presencia de mutaciones en el gen p53 en sangre aumenta el riesgo de desarrollar aterosclerosis, la principal causa de enfermedad cardiovascular.
16 Jan 2023

A CNIC study extends the understanding of how acquired mutations in blood cells act as a new cardiovascular risk factor

Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
23 Dec 2022

A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces

Las células senescentes (mostradas por luminiscencia) aparecieron en el hombro de ratón después de la lesión
19 Dec 2022

The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people and for improving muscle repair in young healthy people

3 Nov 2022

CNIC scientists have identified a molecular mechanism that accounts for the arrhythmias, skeletal muscle weakness, and periodic paralysis in patients with this rare disease

Los complejos I, III, y IV de la cadena de transporte electrónico mitocondrial se asocian formando grandes estructuras llamadas supercomplejos.  SCAF1 determina la asociación entre complejos de la cadena de transporte mitocondrial.
18 Oct 2022

A study, published in Nature Metabolism, is the first to demonstrate the key role played by mitochondria in adapting metabolism to different energy demands in humans

An optical section from a ventral view of a mouse embryo at embryonic day E8.0. The section is overlain with a cast of the three-dimensional shape of the forming heart (red) and the incipient circulatory system (purple).
17 May 2022

The 3D atlas has allowed the scientists to identify the beginning of left–right asymmetry in the heart

18 Apr 2022

The research will provide insights into the development of potential treatments for neurological diseases and obesity, among other human conditions

María García García, Miguel Ángel del Pozo Barriuso, Sara Sánchez Perales, Laura Sotodosos-Alonso, Enrique Calvo, Jesús Vázquez y Asier Echarri
3 Mar 2022

Most biological processes require the import to the cell nucleus of key regulatory factors; one of the most important of these factors is the protein YAP

José Javier Fuster
About the CNIC
23 Feb 2022

Researchers from the CNIC and Columbia University (USA) review the role of acquired mutations and clonal hematopoiesis in cardiovascular disease

Miguel Palomino Segura, Georgiana Crainiciuc, Jon Sicilia y Andrés Hidalgo
5 Jan 2022

Scientists at the CNIC have developed a simple model for studying the behavior of immune cells in live animals and have identified a harmful cell behavior pattern associated with cardiovascular disease