Biomarkers for the diagnosis and prognosis of aortic aneurysm

  • Scientists at the Centro Nacional de Investigaciones Cardiovasculares and Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) have discovered that the nitric oxide (NO) pathway is overactivated in the aortas of mice and patients with Marfan Syndrome and that the activity of this pathway causes the aortic aneurysms that characterize this disease.

    This discovery has important implications for patients with this syndrome, because these molecules could be used as biomarkers for disease monitoring, and we are now studying their potential as prognostic indicators. 

     

    Scientific publication

    Number
    EP21382325
    Priority date
    16/04/2021
    Applicants
    CNIC, CSIC, UAM
    Inventors
    Juan Miguel Redondo Moya, Jesús Vázquez Cobos, Marta Toral Jiménez, Andrea de la Fuente Alonso, María Jesús Ruiz Rodríguez, Álvaro Alfayate Hernández