New method for the diagnosis of atherosclerosis

  • Inflammation is an active driver of atherosclerotic plaque development and a risk factor for atherosclerotic events. It is therefore of utmost importance to understand the mechanisms behind these inflammatory processes and to be able to develop new diagnostics and treatment modalities for atherosclerotic disorders.

    CNIC, FJD (Fundación Jiménez Díaz) and UAM (Universidad Autónoma de Madrid) researchers conducted a study to identify new antibodies that show reactivity against the atherosclerotic plaque. They have found that one of these antibodies recognizes a mitochondrial dehydrogenase of the proline metabolism (PRODH). The levels of this protein are increased in the plasma of atherosclerotic mice and humans with carotid disease, supporting the potential use of this PRODH as a biomarker for atherosclerosis.

    Number
    EP19382817.5
    Priority date
    23/09/2019
    Applicants
    CNIC, FJD, UAM
    Inventors
    Almudena Rodríguez Ramiro, Cristina Lorenzo Martín, Jesús Vázquez Cobos, José Luis Martín Ventura, Alejandro Sanz Bravo, Pilar Delgado Cañaveras, Elena Bonzón Kulichenko