We are searching a Postdoctoral Researcher to join the Molecular Cardiology research group of Prof. Silvia G. Priori at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid.
The Molecular Cardiology Laboratory is focused on discovering the genetic causes of sudden cardiac death and developing gene therapy strategies to treat cardiac arrhythmias.
Dr. Priori will establish at the CNIC a translational and clinical research program in cardiovascular genetics, with a particular focus on inherited channelopathies and other inherited forms of heart disease. Beginning almost two decades ago, Dr. Priori established a clinical database of patients with known or suspected inherited arrhythmias, including long QT syndrome, Brugada syndrome, catecholaminergic polymorphic VT (CPVT), ARVC, short QT syndrome and related disorders. Her work defined the genetic basis for CPVT and her clinical database analyses have facilitated genotype-phenotype studies that have been of major clinical importance. Dr. Priori’s Laboratory will focus on establishing and characterizing murine and pig models of the various human inherited channelopathies, with the goal of developing targeted gene and/or pharmacologic therapies for these disorders.
Summary of the job description
The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) (National Center for Cardiovascular Research Carlos III) is a public institution dedicated to cardiovascular research that opened on December 15th 2005 when the Spanish Prime Minister, José Luis Rodríguez Zapatero, presided at the creation of the Pro CNIC Foundation, through which some of the most important Spanish companies have agreed to provide a significant part of the funding for the research activity at the CNIC. The CNIC’s three main areas of activity are Scientific Research, Translational Medicine and Excellent Training. A major focus of CNIC is to provide an excellent training to young scientists with a special attention to ensure the presence of a truly international environment.
The CNIC is considering applications for a Postdoctoral Position for the Molecular Cardiology Laboratory directed by Professor Silvia G Priori. The laboratory director, Prof Silvia G Priori, and her team are internationally recognized leaders in the field of genetic causes of sudden cardiac death and gene therapy of cardiac arrhythmias.
The position is for a highly motivated scientist who will be responsible for the design, engineering, early development, and functional analysis of different gene therapy strategies in vitro and in vivo. An important part of the research project in which the candidate will be involved is dedicated to the investigation of induced pluripotent stem cells derived myocytes obtained from blood of individuals with inherited arrhythmias . The candidate will also be involved in the development cutting-edge next-generation molecular approaches to amend molecular abnormalities to cure cardiac genetic diseases.
The position is funded by an advanced research grant of European Research Council awarded to Dr Priori at the CNIC . The ideal candidate will have to be competent in performing critical review of data, experimental troubleshooting, data analysis, and presentation of research data and project updates. The candidate should be aware that the position may require traveling to other laboratories in EU and USA for collaborating to projects with our partner institutions. Preferred candidates will possess solid experience in the field of molecular biology techniques: experience in differentiating induced-pluripotent stem cells-derived cardiac myocytes is considered as an important feature for the position . The candidate is expected to have sound verbal and written communication skills in English.
- PhD in Molecular Biology or related discipline or MD with extensive laboratory research experience
- A minimum of 1+ years of relevant post-doctoral experience and competence in two or more of the following:
- Competence in differentiating induced-pluripotent stem cells-derived cardiac myocytes
- Experience in gene silencing/ gene therapy
- Confocal microscopy
- Cell culture
- Advanced molecular biology techniques
- DNA cloning experience
Additional qualifications relevant to the position:
- Experience with viral vector design, cell culture and production of induced pluripotent stem cells-derived cardiac myocytes
- Knowledge of cardiac electrophysiology and arrhythmia pathophysiology
- Publication record and/or documented experience in advancing viral vector products through pre-clinical development
- Knowledge of laboratory quality standards including BSL2 safety policies
Other desired professional skills:
- Strong presentation and writing skills
- Availability to spend part of the work abroad (Spain and USA)
- Capability of working in a team, but able to plan and work independently
- Ability to work in a fast-paced and competitive field
Salary and Duration:
Competitive salary is ensured and will be in the range of 27,000 – 37,442 € according to the candidate’s expertise and qualification. The initial contract duration is 3 years and the contract will be renewable at the term.
Candidates are encouraged to apply providing 1) a letter that explains the reasons for being interested in this job, 2) a CV with list of publications,; three recommendation letters of previous mentors who have either known the candidate during her/his research activities or who have expertise in the field of the thesis or the research topic of the candidate.
Please submit your application in a single pdf file using the link available at the CNIC HR web page.
CNIC is an inclusive, equal opportunity employer, irrespective of nationality, ethnic origin, gender, marital or parental status, sexual orientation, creed, disability, age or political belief. Confidentiality is guaranteed throughout the selection process and all current regulations relating to the protection of personal data will be strictly adhered to.
"En caso de ausencia de alguno de los evaluadores se nombrará un evaluador alternativo de la misma área"