Postdoctoral Researcher for the Cardiac Arrhythmias group

The Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) CNIC has been conceived to develop research of excellence, competitive and of international relevance in relation to cardiovascular diseases. The CNIC has a research centre of 24,000 m², located in Madrid, with more than 6,000 m² for laboratories equipped with a state-of-the-art infrastructure and equipment.

Functions:

He/She will conduct postdoctoral research on the mechanisms of arrhythmias and atrial fibrillation in experimental models as well as in-vitro human ones (iPSC-CMs). He/She will participate in studies on cellular electrophysiology, epigenetics, molecular biology, imaging, and biomarkers of atrial fibrillation progression.

This position may be funded by the European Union’s Horizon 2020 research and innovation programme (Grant Agreement number: GA-965286, acronym: MAESTRIA)

Mandatory Requirements

1. PhD in area of life sciences.
2. Minimum experience of 8 years in biomedical research centers.

Valuable Requirements:

• C1. Expertise and knowledge in cellular electrophysiology (patch-clamp) on isolated adult cardiomyocytes and iPSC-CMs, calcium imaging by confocal microscopy in intact and permeabilized cells, echocardiography, MRI, and cardiac electrophysiology in experimental models.
• C2. Expertise in isolating cardiomyocytes from experimental models.
• C3. Expertise and knowledge in experimental models surgery for the generation of models of cardiac hypertrophy and heart failure (TAC, heart infarction, etc.).
• C4. Expertise in the mechanisms of cardiac arrhythmias, including atrial and ventricular fibrillation.
• C5. Expertise and knowledge in the construction of adeno-associated viruses (AAV) for in vivo intravenous gene transfection in experimental models, and in protein immunolocalization using fluorescence microscopy.
• C6. Advanced expertise and knowledge of cell biology, transfections, immortalization, proliferation assays, etc., especially focused on genomics, proteomics, transcriptomics, and epigenetics.
• C7. Expertise and knowledge of experimental biochemistry and molecular biology techniques (DNA extraction, PCR, Western blot, etc.).
• C8. Interview.

Positive action: a correction index of 1.5 is established for each year of experience in the evaluation of the number of years in those criteria where experience is evaluated, in the event that the disable person greater than 66% and 1.2 in the event that the disable person greater than 30%.

We offer:

• Joining a modern Research Center of international relevance in the scientific field.
• Integration into young teams in an environment of scientific excellence.
• Access to a modern infrastructure with the most advanced technology.
• Training in the latest advances, both technical and scientific.
• Postdoctoral research contract of 3 years duration, extendable up to the maximum limit of 6 years, in accordance with Art. 22 Law of Science, Technology and Innovation (texto refundido Ley 14/2011, de 1 de junio, de la Ciencia, la Tecnología y la Innovación), as long as the selected candidate complies with the legal requirements for the formalization of the contract in accordance with the Spanish labor law.
• The position may be filled by an interim contract until the selection process is completed
• Immediate incorporation

Recruiment Plan:

The RESOLUTION OF THE SECRETARIAT OF STATE FOR PUBLIC FUNCTION APPROVING THE COMMON ACTION CRITERIA FOR THE RECRUITMENT PROCESSES IN THE STATE PUBLIC SECTOR ENTITIES of April 11, 2022, sets forth in point 6.1 that “Unless a specific regulation establishes a merit-bases recruitment system (“concurso”), the competition (“concurso-oposición”) must be the recruitment system”.

In CNIC, the specific regulations approved by the Foundation's board of trustees establish a merit-based recruitment system (“concurso”) including a personal interview.

At least the 3 candidates with the highest score, as long as they reach the minimum of 65 points as a sum of criteria (C1-C7), will be interviewed.  The three candidates with the highest score will be hired given the candidate reaches at least total score (C1-C8) of 80 points.

Recruitment Commission:

• Principal Investigator of the group
• Posdoctoral group member
• Research Office Manager
• Research Office Technician
• HR member

The CNIC guarantees, in its field of action, the principle of equality in access to employment, and cannot establish any discrimination, direct or indirect, based on reasons of origin, including racial or ethnic, sex, age, marital status, religion or convictions, political opinion, sexual orientation and identity, gender expression, sexual characteristics, union affiliation, social condition, language within the State and disability, provided that the workers are in conditions of aptitude to carry out the work or employment for which try they are assigned.

By participating in the selection process, the participant agrees that their data appear in the public resolutions of the selection process. Such resolutions (provisional list of admitted and excluded, definitive list of admitted and excluded and resolution of the process) are published on the CNIC website.

Score criteria:

C1. Expertise and knowledge in cellular electrophysiology (patch-clamp) on isolated adult cardiomyocytes and iPSC-CMs, calcium imaging by confocal microscopy in intact and permeabilized cells, echocardiography, MRI, and cardiac electrophysiology in experimental models. (The overall experience will be assessed based on the time and specialty.) 20%

C2. Expertise in isolating cardiomyocytes from experimental models. (The overall experience will be assessed based on the time and specialty). 15%

C3. Expertise and knowledge in experimental models surgery for the generation of models of cardiac hypertrophy and heart failure (TAC, heart infarction, etc.). (The overall experience will be assessed based on the time and specialty). 10%

C4. Expertise in the mechanisms of cardiac arrhythmias, including atrial and ventricular fibrillation. (The overall experience will be assessed based on the time and specialty). 10%

C5. Expertise and knowledge in the construction of adeno-associated viruses (AAV) for in vivo intravenous gene transfection in experimental models, and in protein immunolocalization using fluorescence microscopy. (The overall experience will be assessed based on the time and specialty). 10%

C6. Advanced expertise and knowledge of cell biology, transfections, immortalization, proliferation assays, etc., especially focused on genomics, proteomics, transcriptomics, and epigenetics. (The overall experience will be assessed based on the time and specialty). 5%

C7. Expertise and knowledge of experimental biochemistry and molecular biology techniques (DNA extraction, PCR, Western blot, etc.). (The overall experience will be assessed based on the time and specialty). 10%

C8. Interview. 20%