Somos un equipo de científicos multidisciplinar que investiga cómo las fuerzas mecánicas determinan la función muscular a nivel molecular, celular, tisular y de organismo. Nuestra motivación es mejorar el entendimiento, diagnóstico y tratamiento de enfermedades musculo-esqueléticas y cardiovasculares. A la vez, formamos científicos, despertamos vocaciones en ciencia, y contribuimos a afianzar y difundir la cultura científica.
Las enfermedades cardiovasculares (ECV) son el principal problema sanitario y socio-económico en todo el mundo, en parte debido al envejecimiento progresivo que la población mundial está experimentando. La arteriosclerosis y la insuficiencia cardiaca contribuyen significativamente a la morbimortalidad relacionada con ECV en los ancianos.
Blood vessels are not mere conduits for the body’s fluids; they also control essential biological responses and are an important therapeutic target in cancer and cardiovascular diseases.
Los infartos y muchos casos de ictus isquémicos son provocados por la aterosclerosis, una enfermedad extremadamente extendida que ataca las arterias de personas de todo el mundo.
The Multidisciplinary Translational Research (MTCR) Group of CNIC is a platform for innovative knowledge generation in health and disease.
We study the role of signaling pathways in cardiovascular development with the goal of identifying disease mechanisms and biomarkers.
The interplay of cells and tissues with mechanical forces from their environment emerges as a novel key aspect of both organismal homeostasis and disease.
Nuestro laboratorio se centra en la investigación de la cadena de transporte de electrones mitocondrial de mamíferos (MtETC) y la H+-ATP sintetasa, que en conjunto constituyen el sistema de fosforilación oxidativa (OXPHOS), centrándose en comprender el papel de las mitocondrias como integradores principales del metabolismo celular.
Nuestro grupo está orientado en la prevención de las enfermedades cardiovasculares y la promoción de la salud. Trabajamos en programas multidisciplinares en estrecha colaboración con colegios y comunidades, dirigidos tanto a niños como a adultos.
The Advanced Development in Arrhythmia Mechanisms and Therapy (ADAM-T) laboratory focuses on investigating from a multidisciplinary approach, the mechanisms underlying cardiac arrhythmias that occur in highly prevalent cardiovascular diseases in the general population, as well as in specific subsets at particular risk of sudden cardiac death.
Our group has developed research applications for noninvasive, high-resolution and high-sensitivity imaging technologies to support translational research and population studies in preclinical atherosclerosis.
Nuestro grupo investiga la interacción entre el sistema hematopoyético y el sistema cardiovascular en el contexto de la enfermedad cardiovascular, con un interés particular en la fisiopatología de la aterosclerosis, la principal causa de infartos cardíacos e ictus cerebrales.
Angiogenesis, the formation of new capillaries, is closely linked to inflammation.
Our laboratory is interested in innate immune cells. Macrophages, a major cellular component of innate immunity, are conspicuously present in most organs in which they are endowed with specialized phenotypes and functions that support normal tissue integrity. How they acquire these properties in certain organs, like the heart, is unknown.
Our laboratory focuses on the study of myocardial diseases, ranging from ischemia/reperfusion to heart failure, including that associated with cancer therapy-induced cardiotoxicity.
El enfoque general del laboratorio del Dr. Jalife es la comprensión de los mecanismos celulares y moleculares de las arritmias y la muerte súbita cardíaca (MSC).
Our lab studies the molecular mechanisms that regulate the development of heart failure.
The central research aim of the CNIC Functional Genomics Research Group is to understand how genome activity is regulated during development and how it contributes to human disease. For this, our projects are aimed to search for and identify distal acting cis-regulatory sequences, and elucidate how they act on their target genes.
Nuestro grupo estudia el potencial terapéutico y diagnóstico de las células T, sus receptores inmunomoduladores y los microRNAs, en el manejo de las enfermedades cardiovasculares (ECV) y en el desarrollo de herramientas de medicina de precisión.
El epicardio es una capa epitelial unicelular que recubre el miocardio. Se desarrolla a partir del proepicardio (PE), un grupo de células que se forman en el tracto de entrada del tubo cardiaco.
The interest of our group is cerebrovascular disease, one of the leading causes of death and disability, with an increasing prevalence due to the ageing of the population.
Our group aims to understand the cellular and molecular mechanisms regulating striated muscle regeneration and growth in physiology and pathology, as well as in aging.
Formulation of drugs into nanoparticles can potentially improve their pharmacokinetics, stability and toxicity profile, thereby augmenting their therapeutic index. In addition, nanomedicines can be designed to selectively deliver their cargo to a specific tissue or cell population.
La muerte súbita cardíaca (MSC) es una de las principales causas de mortalidad en los países occidentales. Por edades, en las personas mayores la enfermedad coronaria arterial es la mayor causante de la MSC, mientras que en individuos jóvenes la causa principal de la MSC son las enfermedades arritmogénicas hereditarias.
Our lab is interested in various aspects of B cell biology, in particular the regulatory and diversification events that take place in germinal centers.
Many important biological processes, including the regulation and development of the immune and cardiovascular systems, are regulated by the calcineurin (CN)/NFAT pathway. Much of our previous work relates to molecular interactions of CN with substrates. We are now studying the regulation and function of this pathway in inflammation, cardiovascular and inflammatory diseases.
Our group investigates the transcriptional and epigenetic control of immune and cardiovascular cells in homeostasis and disease, with a particular focus on the molecular mechanisms underlying the actions of nuclear receptors.
Metabolic syndrome is a medical disorder defined by the co-occurrence of obesity, impaired glucose tolerance, dyslipidemia and hypertension.
Intercellular communication is fundamental to the innate and adaptive immune responses.
Nuestra investigación actual se centra en la función de las células dendríticas (DC) y los macrófagos como centinelas inmunes clave que inician y modulan la inmunidad, la inflamación y la tolerancia. La manipulación de estas células es prometedora como una potente herramienta de inmunoterapia para muchas enfermedades con un componente inmunológico, incluidas las enfermedades infecciosas, las enfermedades autoinmunes, las enfermedades cardiovasculares (CVD) y el cáncer.
We are interested in understanding the cellular basis of developmental processes and how this is controlled by transcription factor networks (TFN). We have developed genetic methods in the mouse that allow us to trace cell lineages using clonal analysis or functional mosaics.
Our group works on the development of high-throughput quantitative approaches for the dynamic analysis of the deep proteome, which are being applied to basic and translational projects in the cardiovascular field.
