Somos un equipo de científicos multidisciplinar que investiga cómo las fuerzas mecánicas determinan la función muscular a nivel molecular, celular, tisular y de organismo. Nuestra motivación es mejorar el entendimiento, diagnóstico y tratamiento de enfermedades musculo-esqueléticas y cardiovasculares. A la vez, formamos científicos, despertamos vocaciones en ciencia, y contribuimos a afianzar y difundir la cultura científica.
La Organización Mundial de la Salud ha estimado que las enfermedades cardiovasculares serán en el año 2020 el principal problema sanitario y socio-económico en todo el mundo, en parte debido al envejecimiento progresivo que la población mundial está experimentando.
Blood vessels are not mere conduits for the body’s fluids; they also control essential biological responses and are an important therapeutic target in cancer and cardiovascular diseases.
Los infartos y muchos casos de ictus isquémicos son provocados por la aterosclerosis, una enfermedad extremadamente extendida que ataca las arterias de personas de todo el mundo.
Our research into cardiovascular disease is based on a simple principle: create to understand, create to treat.
The Multidisciplinary Translational Research (MTCR) Group of CNIC is a platform for innovative knowledge generation in health and disease.
We are interested in the molecular mechanisms that regulate cardiovascular development, homeostasis and disease. Most of our effort centers on the study of the Notch pathway.
Signals are the language of life, mediating the communication essential for cells proper behavior.
Our laboratory researches the mammalian mitochondrial electron transport chain (MtETC) and H+-ATP synthase, which together constitute the oxidative phosphorylation (OXPHOS) system.
El laboratorio se centra en el abordaje multidisciplinar de los mecanismos que subyacen las arritmias cardíacas derivadas de enfermedades cardiovasculares con alta prevalencia en la población general, así como en poblaciones concretas con alto riesgo de muerte súbita.
Our group has developed research applications for noninvasive, high-resolution and high-sensitivity imaging technologies to support translational research and population studies in preclinical atherosclerosis.
Our laboratory investigates the interplay between the hematopoietic and the cardiovascular systems in the context of cardiovascular disease, with a particular focus on the pathophysiology of atherosclerosis, the underlying cause of most heart attacks and strokes.
Angiogenesis, the formation of new capillaries, is closely linked to inflammation.
Our laboratory is interested in innate immune cells. Macrophages, a major cellular component of innate immunity, are conspicuously present in most organs in which they are endowed with specialized phenotypes and functions that support normal tissue integrity. How they acquire these properties in certain organs, like the heart, is unknown.
Our laboratory focuses on the study of myocardial diseases, ranging from ischemia/reperfusion to heart failure. Our studies span the molecular origins of disease and their manifestations at the macro-anatomical and physiological levels, and our group includes experts in molecular biology, clinical cardiology and cardiovascular imaging.
El enfoque general del laboratorio del Dr. Jalife es la comprensión de los mecanismos celulares y moleculares de las arritmias y la muerte súbita cardíaca.
Our lab studies the molecular mechanisms that regulate the development of heart failure. Heart failure is the ultimate consequence of heart disease and it basically represents the inability of the heart to pump blood in an efficient manner due to the lack of proper heart contraction or relaxation.
The central research aim of the CNIC Functional Genomics Research Group is to understand how genome activity is regulated during development and how it contributes to human disease. For this, our projects are aimed to search for and identify distal acting cis-regulatory sequences, and elucidate how they act on their target genes.
Understanding peripheral mechanisms operating in autoinmmune and chronic inflammatory diseases is critical for the design and development of novel therapies against these immunological disorders.
El epicardio es una capa epitelial unicelular que recubre el miocardio. Se desarrolla a partir del proepicardio (PE), un grupo de células que se forman en el tracto de entrada del tubo cardiaco.
Our group aims to understand the cellular and molecular mechanisms regulating striated muscle regeneration and growth in physiology and pathology, as well as in aging.
Formulation of drugs into nanoparticles can potentially improve their pharmacokinetics, stability and toxicity profile, thereby augmenting their therapeutic index. In addition, nanomedicines can be designed to selectively deliver their cargo to a specific tissue or cell population.
La muerte súbita cardíaca (MSC) es una de las principales causas de mortalidad en los países occidentales. Por edades, en las personas mayores la enfermedad coronaria arterial es la mayor causante de la MSC, mientras que en individuos jóvenes la causa principal de la MSC son las enfermedades arritmogénicas hereditarias.
B lymphocytes are key players of the immune response, mostly through the generation of a hugely diverse repertoire of protective antibodies.
Many important biological processes, including the regulation and development of the immune and cardiovascular systems, are regulated by the calcineurin (CN)/NFAT pathway. Much of our previous work relates to molecular interactions of CN with substrates. We are now studying the regulation and function of this pathway in inflammation, cardiovascular and inflammatory diseases.
Nuclear hormone receptors constitute a superfamily of ligandactivated transcription factors with diverse roles in development and homeostasis.
Metabolic syndrome is a medical disorder defined by the co-occurrence of obesity, impaired glucose tolerance, dyslipidemia and hypertension.
Intercellular communication is fundamental to the innate and adaptive immune responses.
Las células dendríticas (DCs) son centinelas de nuestro sistema inmunológico que inician y modulan la inmunidad o la tolerancia. La manipulación de las DCs es una herramienta prometedora para el tratamiento de muchas enfermedades que tienen un componente inmunológico, incluyendo las enfermedades infecciosas, enfermedades cardiovasculares, enfermedades autoinmunes o cáncer.
We are interested in understanding the cellular basis of developmental processes and how this is controlled by transcription factor networks (TFN). We have developed genetic methods in the mouse that allow us to trace cell lineages using clonal analysis or functional mosaics.
Our group works on the development of high-throughput quantitative approaches for the dynamic analysis of the deep proteome, which are being applied to basic and translational projects in the cardiovascular field.
