Proteómica cardiovascular

Dr. Jesús Vázquez graduated in Physical Chemistry at the Universidad Complutense (Madrid, 1982) and carried out his PhD in Biochemistry at the Universidad Autónoma (Madrid, 1986), both with Special Distinction. During his postdoctoral training at Merck Sharp Research Laboratories (NJ, USA) and at the Centro de Biología Molecular Severo Ochoa (Madrid), he specialized in protein chemistry and in the study of biomembranes in the context of neurochemical diseases. Since then, he has played a pioneering role in the development of protein chemistry, mass spectrometry and proteomics in Spain. His laboratory has made relevant contributions to the field addressing subjects such as peptide fragmentation mechanisms, de novo peptide sequencing, and analysis of posttranslational modifications. In the last years he has devoted a considerable effort in the development of second generation techniques, relative proteome quantification by stable isotope labeling, advanced algorithms for quantitative data integration and systems biology, and high-throughput characterization of modifications produced by oxidative stress. These techniques have been applied to several research projects, including the study of molecular mechanisms underlying processes such as angiogenesis and nitroxidative stress in endothelium, of ischemia-preconditioning in cardiomyocites and of the interactome at the immune synapse. Author of more than 130 international publicatons, he is Profesor de Investigación of the CSIC and director of the Proteomics Platform of RECAVA (Spanish Cardiovascular Research Network). He joined the CNIC as a Full Professor in 2011, where he leads the Cardiovascular Proteomics laboratory.