Group leader
Ext. 70203

Dr. Jesús Vázquez graduated in Physical Chemistry at the Universidad Complutense (Madrid, 1982) and carried out his PhD in Biochemistry at the Universidad Autónoma (Madrid, 1986), both with Special Distinction. During his postdoctoral training at Merck Sharp Research Laboratories (NJ, USA) and at the Centro de Biología Molecular Severo Ochoa (Madrid), he specialized in protein chemistry and in the study of biomembranes in the context of neurochemical diseases. Since then, he has played a pioneering role in the development of protein chemistry, mass spectrometry and proteomics in Spain. He is Profesor de Investigación del CSIC and joined the CNIC (Centro Nacional de Investigaciones Cardiovasculares, Madrid) as a Full Professor in 2011, where he leads the Cardiovascular Proteomics laboratory and is in charge of the Proteomics and Metabolomics Unit.

His group works on the development of high-throughput quantitative approaches for the dynamic analysis of the deep proteome, which are being applied to basic and translational projects in the cardiovascular field. They are developing novel bioinformatics algorithms for the analysis of very large numbers of samples, including protein identification and systems biology interpretation of quantitative data and for the study of posttranslational modifications (PTM).

They have developed a novel data-independent mass spectrometry scanning technique (DiS) that improves on the performance of conventional shotgun approaches and also allows in-silico-targeted quantification of any suspected peptide, including PTMs. They are using an extension of this technique (Blue-DiS) to generate an extremely detailed structural map of components of mitochondrial oxidative phosphorylation supercomplexes in several models, which include characterization of novel factors and PTMs that modulate complex and supercomplex assembly.

They are also performing translational studies in large cohorts of human samples to uncover molecular mechanisms and biomarkers of cardiovascular disease. They are studying the spatial proteome alterations taking place during the early development of the atherosclerotic plaque, and the plasma proteome from participants in the PESA study. They have identified a set of biomarkers that predict the presence of subclinical atherosclerosis in plasma, which we are validating in large human cohorts, and are protected by a patent in process of exploitation by a private company in several countries throughout the world.

Finally, they have developed a novel technology for the untargeted analysis and quantification of all posttranslational modifications (PTM) detectable by mass spectrometry. They are applying this technology to characterize the dynamic PTM landscape of human arterial lessions and plasma in the context of subclinical atherosclerosis and aortic aneurisms. The group is currently involved in the development of ultra-high sensitive approaches for the analysis of isolated cell populations.

J.Vázquez has published more than 250 international, peer-reviewed publications that have been received more than 1.000 citations per year, and as an H-index of 54.

Other members
Surname and name Position CV Extension Email
Jorge Cerrudo Inmaculada Assistant researcher --- Ext. 70137 Contact
Marín Vicente Consolación Assistant researcher --- Ext. 70727 Contact
Núñez Sánchez Estefanía Assistant researcher --- Ext. 70365 Contact
Folgueira Cintia Postdoc researcher --- Ext. 70561 Contact
Guerrero Sánchez Víctor Manuel Postdoc researcher --- Ext. 70761 Contact
Martínez del Val Ana Postdoc researcher --- Ext. 70876 Contact
Barrero Rodríguez Rafael Predoc researcher --- Ext. 70500 Contact
Del Río Aledo David Predoc researcher --- Ext. 70899 Contact
Devesa Arbiol Cristina Amparo Predoc researcher --- Ext. 70302 Contact
Ruiz Garrido Irene Predoc researcher --- Ext. 70670 Contact
Mena Santos Diego Researcher in Training --- Ext. 70158 Contact
de la Fuente Alonso Andrea Graduate technician --- Ext. 70513 Contact
Deniz Eyre Nauzet Celso Graduate technician --- Ext. 70732 Contact
Alonso Aguado Ana Belén Visiting scientist --- Contact
Borràs Querol Carla Visiting scientist --- Ext. 70822 Contact
Cerro Pardo Isabel Visiting scientist --- Ext. 70102 Contact
Ertekin Özkan Zehra Ceren Visiting scientist --- Ext. 70233 Contact
Lozano Prieto Marta Visiting scientist --- Ext. 70425 Contact
Martin Noa Visiting scientist --- Ext. 70731 Contact
Pérez-Campoamor Manzaneque Antonio Visiting scientist --- Ext. 70748 Contact
Pertusa Viñuales Clara María Visiting scientist --- Ext. 70801 Contact
Picos Mora María Cinta Visiting scientist --- Ext. 70326 Contact
González Calatayud Alberto Visiting student --- Ext. 71069 Contact