We are a multidisciplinary team of scientists who investigate how mechanical forces determine muscle function at the molecular, cellular, tissue and organismal levels. Our motivation is to improve the understanding, diagnosis and treatment of cardiovascular and musculoskeletal diseases. At the same time, we train scientists, awake vocations in science and contribute to strengthen and disseminate the scientific culture.
Cardiovascular disease (CVD) is the main health and socio-economic problem worldwide, in part due to the progressive aging that the world population is experiencing. Atherosclerosis and heart failure contribute significantly to CVD-related morbimortality in the elderly.
Blood vessels are not mere conduits for the body’s fluids; they also control essential biological responses and are an important therapeutic target in cancer and cardiovascular diseases.
Heart attack and many cases of ischemic stroke is the result of atherosclerosis; an extremely widespread disease that attacks arteries of humans all over the world. Our research group is devoted to finding new ways of preventing the development of dangerous atherosclerosis, and we focus on two key challenges that currently limit our ability to combat the disease.
Our research into cardiovascular disease is based on a simple principle: create to understand, create to treat.
The Multidisciplinary Translational Research (MTCR) Group of CNIC is a platform for innovative knowledge generation in health and disease.
We study the role of signaling pathways in cardiovascular development with the goal of identifying disease mechanisms and biomarkers.
The interplay of cells and tissues with mechanical forces from their environment emerges as a novel key aspect of both organismal homeostasis and disease.
Our laboratory researches the mammalian mitochondrial electron transport chain (MtETC) and H+-ATP synthase, which together constitute the oxidative phosphorylation (OXPHOS) system and is centered in understanding the role of mitochondria as major integrator of the cellular metabolism.
Our group focuses on cardiovascular disease prevention and health promotion. We work on multidisciplinary programs in close collaboration with schools and communities, targeting both children and adults.
The Advanced Development in Arrhythmia Mechanisms and Therapy (ADAM-T) laboratory focuses on investigating from a multidisciplinary approach, the mechanisms underlying cardiac arrhythmias that occur in highly prevalent cardiovascular diseases in the general population, as well as in specific subsets at particular risk of sudden cardiac death.
Our group has developed research applications for noninvasive, high-resolution and high-sensitivity imaging technologies to support translational research and population studies in preclinical atherosclerosis.
Our laboratory investigates the interplay between the hematopoietic and the cardiovascular systems in the context of cardiovascular disease, with a particular focus on the pathophysiology of atherosclerosis, the underlying cause of most heart attacks and strokes.
Angiogenesis, the formation of new capillaries, is closely linked to inflammation.
Our laboratory is interested in the biology of inflammation and immune cells.
Our laboratory focuses on the study of myocardial diseases, ranging from ischemia/reperfusion to heart failure, including that associated with cancer therapy-induced cardiotoxicity.
The general focus of Dr. Jalife's laboratory is the understanding of the cellular and molecular mechanisms of arrhythmias and sudden cardiac death (SCD).
Our lab studies the molecular mechanisms that regulate the development of heart failure.
The central research aim of the CNIC Functional Genomics Research Group is to understand how genome activity is regulated during development and how it contributes to human disease. For this, our projects are aimed to search for and identify distal acting cis-regulatory sequences, and elucidate how they act on their target genes.
Our group seeks to study the therapeutic and diagnostic potential of T cells, their immunomodulatory receptors and microRNAs, in the management of cardiovascular disease (CVD) and in the development of precision medicine tools.
The epicardium is a unicellular epithelial layer of that envelops the myocardium. It derives from the proepicardium (PE), a group of cells that arises at the inflow tract of the forming heart. PE cells attach to the myocardium and form an epithelial covering, called the epicardium.
The interest of our group is cerebrovascular disease, one of the leading causes of death and disability, with an increasing prevalence due to the ageing of the population.
Our group aims to understand the cellular and molecular mechanisms regulating striated muscle regeneration and growth in physiology and pathology, as well as in aging.
Formulation of drugs into nanoparticles can potentially improve their pharmacokinetics, stability and toxicity profile, thereby augmenting their therapeutic index. In addition, nanomedicines can be designed to selectively deliver their cargo to a specific tissue or cell population.
Sudden cardiac death (SCD) is a leading cause of death in western countries: coronary artery disease is the major cause of SCD in older subjects while inherited arrhythmogenic diseases are the leading cause of SCD in younger individuals.
B lymphocytes are key players of the immune response, mostly through the generation of a hugely diverse repertoire of protective antibodies that recognize pathogens and foreign molecules with exquisite specificity. However, misregulation of B lymphocyte function can also associate with multiple health conditions, including immune deficiencies, autoimmunity and cancer.
Many important biological processes, including the regulation and development of the immune and cardiovascular systems, are regulated by the calcineurin (CN)/NFAT pathway. Much of our previous work relates to molecular interactions of CN with substrates. We are now studying the regulation and function of this pathway in inflammation, cardiovascular and inflammatory diseases.
Our group investigates the transcriptional and epigenetic control of immune and cardiovascular cells in homeostasis and disease, with a particular focus on the molecular mechanisms underlying the actions of nuclear receptors.
Metabolic syndrome is a medical disorder defined by the co-occurrence of obesity, impaired glucose tolerance, dyslipidemia and hypertension.
Intercellular communication is fundamental to the innate and adaptive immune responses.
Our current research is focused on the function of dendritic cells (DCs) and macrophages as key immune sentinels that initiate and modulate immunity, inflammation and tolerance. Manipulation of these cells holds promise as a potent immunotherapy tool for many diseases with an immune component, including infectious diseases, autoimmune diseases, cardiovascular diseases (CVD) and cancer.
We are interested in understanding the cellular basis of developmental processes and how this is controlled by transcription factor networks (TFN). We have developed genetic methods in the mouse that allow us to trace cell lineages using clonal analysis or functional mosaics.
Our group works on the development of high-throughput quantitative approaches for the dynamic analysis of the deep proteome, which are being applied to basic and translational projects in the cardiovascular field.