Selected publications

Del Fresno C, Saz-Leal P, Enamorado M, Wculek SK, Martinez-Cano S, Blanco-Menendez N, Schulz O, Schulz O, Gallizioli M, Miro-Mur F, Cano E, Planas A, Sancho D. DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment. Science (2018) 362:351-6
del Fresno C, Iborra S, Saz-Leal P, Martínez-López M, Sancho D. Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation. Front Immunol (2018) 9:804
Izquierdo HM, Brandi P, Gomez MJ, Conde-Garrosa R, Priego E, Enamorado M, Martinez-Cano S, Sanchez I, Conejero L, Jimenez-Carretero D, Martin-Puig S, Guilliams M, Sancho D. Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function. Cell Rep (2018) 24:1738-49
Enamorado M, Khouili SC, Iborra S, Sancho D. Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8(+) T Cells. Front Immunol (2018) 9:1751
Saz-Leal P, Del Fresno C, Brandi P, Martinez-Cano S, Dungan OM, Chisholm JD, Kerr WG, Sancho D. Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection. Cell Rep (2018) 25:1118-26
Enamorado M, Iborra S, Priego E, Cueto FJ, Quintana JA, Martínez-Cano S, Mejías-Pérez E, Esteban M, Melero I, Hidalgo A, Sancho D. Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells. Nat Commun (2017) 8:16073
Sancho D, Enamorado M, Garaude J. Innate Immune Function of Mitochondrial Metabolism. Front Immunol (2017) 8:527
Conejero L, Khouili SC, Martinez-Cano S, Izquierdo HM, Brandi P, Sancho D. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight (2017) 2:90420
Garaude J*, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA*, Sancho D* (JG, JAE and DS are co-corresponding authors) Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defence Nat Immunol (2016) 17:1037-45
Iborra S , Martínez-López M, Khouili SC, Enamorado M, Cueto FJ, Conde-Garrosa R, del Fresno C, Sancho D Optimal generation of tissue-resident but not circulating memory T cells during viral infection requires crosspriming by DNGR-1+ dendritic cells Immunity (2016) 45:847-60
Iborra S, Martinez-Lopez M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martin Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D. Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection. Immunity (2016) 45:788-801
Sanchez-Paulete AR, Cueto FJ, Martinez-Lopez M, Labiano S, Morales-Kastresana A, Rodriguez-Ruiz ME, Jure-Kunkel M, Azpilikueta A, Aznar MA, Quetglas JI, Sancho D*, Melero I* (DS and IM are co-senior and co-corresponding authors) Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells. Cancer Discov (2016) 6:71-9
Blanco-Menendez N*, Del Fresno C*, Fernandes S, Calvo E, Conde-Garrosa R, Kerr WG, Sancho D (NBM and CF contributed equally) SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans. J Immunol (2015) 195:4466-78
Sancho D, Reis E Sousa C. Sensing of cell death by myeloid C-type lectin receptors. Curr Opin Immunol (2013) 25:46-52
Sancho D, Reis E Sousa C. Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis. Annu Rev Immunol (2012) 30:491-529
Iborra S, Izquierdo HM, Martínez-López M, Blanco-Menéndez N, Reis E Sousa C, Sancho D. The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice. J Clin Invest (2012) 122:1628-43
Sancho D, Joffre OP, Keller AM, Rogers NC, Martinez D, Hernanz-Falcon P, Rosewell I, Reis e Sousa C Identification of a dendritic cell receptor that couples sensing of necrosis to immunity Nature (2009) 458:899-903
Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest (2008) 118:2098-110