Selected publications

Wculek SK, Cueto FJ, Mujal AM, Melero I, Krummel MF, Sancho D Dendritic cells in cancer immunology and immunotherapy Nat Rev Immunol (2020) 20:7-24
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Acin-Perez R, Iborra S, Marti-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, Munoz MDM, Martinez de Mena R, Krishnan KC, Jimenez C, Bolanos JP, Laakso M, Lusis AJ, Shirihai OS, Sancho D, Enriquez JA Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity Nat Metab (2020) 2:974-988
Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM, Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, Minnerup L, Saz-Leal P, Slack E, Kemp B, Gisbert JP, Dzionek A, Robinson MJ, Rupérez FJ, Cerf-Bensussan N, Brown GD, Bernardo D, LeibundGut-Landmann S, Sancho D. Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. Immunity (2019) 50:446-61
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Wculek SK, Amores-Iniesta J, Conde-Garrosa R, Khouili SC, Melero I, Sancho D Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen J Immunother Cancer (2019) 7:100
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Wculek SK, Khouili SC, Priego E, Heras-Murillo I, Sancho D Metabolic Control of Dendritic Cell Functions: Digesting Information Front Immunol (2019) 10:775
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Del Fresno C, Saz-Leal P, Enamorado M, Wculek SK, Martinez-Cano S, Blanco-Menendez N, Schulz O, Schulz O, Gallizioli M, Miro-Mur F, Cano E, Planas A, Sancho D. DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment. Science (2018) 362:351-6
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Izquierdo HM, Brandi P, Gomez MJ, Conde-Garrosa R, Priego E, Enamorado M, Martinez-Cano S, Sanchez I, Conejero L, Jimenez-Carretero D, Martin-Puig S, Guilliams M, Sancho D. Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function. Cell Rep (2018) 24:1738-49
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Saz-Leal P, Del Fresno C, Brandi P, Martinez-Cano S, Dungan OM, Chisholm JD, Kerr WG, Sancho D. Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection. Cell Rep (2018) 25:1118-26
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del Fresno C, Iborra S, Saz-Leal P, Martínez-López M, Sancho D. Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation. Front Immunol (2018) 9:804
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Enamorado M, Iborra S, Priego E, Cueto FJ, Quintana JA, Martínez-Cano S, Mejías-Pérez E, Esteban M, Melero I, Hidalgo A, Sancho D. Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells. Nat Commun (2017) 8:16073
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Sancho D, Enamorado M, Garaude J. Innate Immune Function of Mitochondrial Metabolism. Front Immunol (2017) 8:527
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Conejero L, Khouili SC, Martinez-Cano S, Izquierdo HM, Brandi P, Sancho D. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production. JCI Insight (2017) 2:90420
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Sanchez-Paulete AR, Cueto FJ, Martinez-Lopez M, Labiano S, Morales-Kastresana A, Rodriguez-Ruiz ME, Jure-Kunkel M, Azpilikueta A, Aznar MA, Quetglas JI, Sancho D*, Melero I* (DS and IM are co-senior and co-corresponding authors) Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells. Cancer Discov (2016) 6:71-9
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Garaude J*, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA*, Sancho D* (JG, JAE and DS are co-corresponding authors) Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defence Nat Immunol (2016) 17:1037-45
Iborra S, Martínez-López M, Khouili SC, Enamorado M, Cueto FJ, Conde-Garrosa R, del Fresno C, Sancho D Optimal generation of tissue-resident but not circulating memory T cells during viral infection requires crosspriming by DNGR-1+ dendritic cells Immunity (2016) 45:847-60
Iborra S, Martinez-Lopez M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martin Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D. Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection. Immunity (2016) 45:788-801
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Blanco-Menendez N*, Del Fresno C*, Fernandes S, Calvo E, Conde-Garrosa R, Kerr WG, Sancho D (NBM and CF contributed equally) SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans. J Immunol (2015) 195:4466-78
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Iborra S, Izquierdo HM, Martínez-López M, Blanco-Menéndez N, Reis E Sousa C, Sancho D. The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice. J Clin Invest (2012) 122:1628-43
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