Selected publications

Alvarez-Prado AF, Perez-Duran P, Perez-Garcia A, Benguria A, Torroja C, de Yebenes VG, Ramiro AR. A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets. J Exp Med (2018) 215:761-771
Link to the full text in Repisalud
Bartolome-Izquierdo N, De Yebenes VG, Alvarez-Prado AF, Mur SM, Lopez JA, Roa S, Vazquez J, Ramiro AR. miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma. Blood (2017) 129:2408-19
Link to the full text in Repisalud
Pérez-García A, Marina-Zárate E, Álvarez-Prado ÁF, Ligos JM, Galjart N, Ramiro AR. CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation. Nat Commun (2017) 8:16067
Azagra A, Roman-Gonzalez L, Collazo O, Rodriguez-Ubreva J, de Yebenes VG, Barneda-Zahonero B, Rodriguez J, Castro de Moura M, Grego-Bessa J, Fernandez-Duran I, Islam AB, Esteller M, Ramiro AR, Ballestar E, Parra M. In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development. J Exp Med (2016) 213:2591-601
Ramiro AR, Barreto VM Activation-induced cytidine deaminase and active cytidine demethylation. Trends Biochem Sci (2015) 40:172-81
Perez-Garcia A, Perez-Duran P, Wossning T, Sernandez IV, Mur SM, Canamero M, Real FX, Ramiro AR. AID-expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway. EMBO Mol Med (2015) 7:1327-36
Link to the full text in Repisalud
de Yebenes VG, Bartolome-Izquierdo N, Nogales-Cadenas R, Perez-Duran P, Mur SM, Martinez N, Di Lisio L, Robbiani DF, Pascual-Montano A, Canamero M, Piris MA and Ramiro AR. miR-217 is an oncogene that enhances the germinal center reaction. Blood (2014) 124:229-39
de Yébenes VG, Bartolomé-Izquierdo N, Ramiro AR. Regulation of B-cell development and function by microRNAs. Immunol Rev (2013) 253:25-39
Pérez-Durán P, Belver L, de Yébenes VG, Delgado P, Pisano DG, Ramiro AR. UNG shapes the specificity of AID-induced somatic hypermutation. J Exp Med (2012) 209:1379-89
Belver L, Papavasiliou FN, Ramiro AR. MicroRNA control of lymphocyte differentiation and function. Curr Opin Immunol (2011) 23:369-73
Belver L, de Yébenes VG, Ramiro AR. MicroRNAs prevent the generation of autoreactive antibodies. Immunity (2010) 33:713-22
de Yebenes VG, Belver L, Pisano DG, Gonzalez S, Villasante A, Croce C, He L, Ramiro AR. miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J Exp Med (2008) 205:2199-206
Ramiro A, Reina San-Martin B, McBride K, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC. The role of activation-induced deaminase in antibody diversification and chromosome translocations. ADV IMMUNOL (2007) 94:75-107
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 440:105-9
de Yébenes VG, Ramiro AR. Activation-induced deaminase: light and dark sides. Trends Mol Med (2006) 12:432-9
Ramiro AR, Jankovic M, Nussenzweig MC. Amplifying Igh translocations. Nat Immunol (2005) 6:117
Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC. AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 118:431-8
Ramiro AR, Stavropoulos P, Jankovic M, Nussenzweig MC. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol (2003) 4:452-6