Publicaciones seleccionadas

Lorenzo C, Delgado P, Busse CE, Sanz-Bravo A, Martos-Folgado I, Bonzon-Kulichenko E, Ferrarini A, Gonzalez-Valdes IB, Mur SM, Roldan-Montero R, Martinez-Lopez D, Martin-Ventura JL, Vazquez J, Wardemann H, Ramiro AR ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies Nature (2021) 589:287–292
Alcaraz-Serna A, Bustos-Morán E, Fernández-Delgado I, Calzada-Fraile D, Torralba D, Marina-Zárate E, Lorenzo-Vivas E, Vázquez E, de Alburquerque JB, Ruef N, Gómez MJ, Sánchez-Cabo F, Dopazo A, Stein JV, Ramiro A, Sánchez-Madrid F Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells Sci Adv (2021) 7:eabb9965
Fuertes T, Ramiro AR, de Yebenes VG miRNA-Based Therapies in B Cell Non-Hodgkin Lymphoma Trends Immunol (2020) 41:932-947
Link to the full text in Repisalud
Delgado P, Alvarez-Prado AF, Marina-Zarate E, Sernandez IV, Mur SM, de la Barrera J, Sanchez-Cabo F, Canamero M, de Molina A, Belver L, de Yebenes VG, Ramiro AR Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma PLoS Genet (2020) 16:e1008960
Fernandez-Messina L, Rodriguez-Galan A, de Yebenes VG, Gutierrez-Vazquez C, Tenreiro S, Seabra MC, Ramiro AR, Sanchez-Madrid F Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production EMBO Rep (2020) :e48925
Link to the full text in Repisalud
de Yebenes VG, Briones AM, Martos-Folgado I, Mur SM, Oller J, Bilal F, Gonzalez-Amor M, Mendez-Barbero N, Silla-Castro JC, Were F, Jimenez-Borreguero LJ, Sanchez-Cabo F, Bueno H, Salaices M, Redondo JM, Ramiro AR Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction Arterioscler Thromb Vasc Biol (2020) 40:2408-2424
Alvarez-Prado AF, Perez-Duran P, Perez-Garcia A, Benguria A, Torroja C, de Yebenes VG, Ramiro AR. A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets. J Exp Med (2018) 215:761-771
Link to the full text in Repisalud
Bartolome-Izquierdo N, De Yebenes VG, Alvarez-Prado AF, Mur SM, Lopez JA, Roa S, Vazquez J, Ramiro AR. miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma. Blood (2017) 129:2408-19
Link to the full text in Repisalud
Pérez-García A, Marina-Zárate E, Álvarez-Prado ÁF, Ligos JM, Galjart N, Ramiro AR. CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation. Nat Commun (2017) 8:16067
Ramiro AR, Barreto VM Activation-induced cytidine deaminase and active cytidine demethylation. Trends Biochem Sci (2015) 40:172-81
Perez-Garcia A, Perez-Duran P, Wossning T, Sernandez IV, Mur SM, Canamero M, Real FX, Ramiro AR. AID-expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway. EMBO Mol Med (2015) 7:1327-36
Link to the full text in Repisalud
de Yebenes VG, Bartolome-Izquierdo N, Nogales-Cadenas R, Perez-Duran P, Mur SM, Martinez N, Di Lisio L, Robbiani DF, Pascual-Montano A, Canamero M, Piris MA and Ramiro AR. miR-217 is an oncogene that enhances the germinal center reaction. Blood (2014) 124:229-39
de Yébenes VG, Bartolomé-Izquierdo N, Ramiro AR. Regulation of B-cell development and function by microRNAs. Immunol Rev (2013) 253:25-39
Pérez-Durán P, Belver L, de Yébenes VG, Delgado P, Pisano DG, Ramiro AR. UNG shapes the specificity of AID-induced somatic hypermutation. J Exp Med (2012) 209:1379-89
Belver L, Papavasiliou FN, Ramiro AR. MicroRNA control of lymphocyte differentiation and function. Curr Opin Immunol (2011) 23:369-73
Belver L, de Yébenes VG, Ramiro AR. MicroRNAs prevent the generation of autoreactive antibodies. Immunity (2010) 33:713-22
de Yebenes VG, Belver L, Pisano DG, Gonzalez S, Villasante A, Croce C, He L, Ramiro AR. miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J Exp Med (2008) 205:2199-206
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 440:105-9