B Lymphocyte Biology
B lymphocytes are key players of the immune response, mostly through the generation of a hugely diverse repertoire of protective antibodies that recognize pathogens and foreign molecules with exquisite specificity. However, misregulation of B lymphocyte function can also associate with multiple health conditions, including immune deficiencies, autoimmunity and cancer.
Our lab is interested in various aspects of B cell biology, in particular the regulatory and diversification events that take place in germinal centers. Diversification in germinal centers entails the remodeling of immunoglobulin genes through two mechanisms called somatic hypermutation (SHM) and class switch recombination (CSR) that allow the generation of long-lived memory B cells and effector plasma cells. Thus, these germinal center events are responsible for improving the affinity and the memory immune response and underlie most of the vaccination strategies used worldwide.
Our recent research has revealed,
- A broad atlas of genes, outside of immunoglobulin genes, that are subject to SHM, with important consequences for oncogenic events during lymphomagenesis (J Exp Med 2018)
- An important interplay between the base excision repair and the SHM machineries in the generation of germinal center lymphomas (PLOS Genetics 2021)
- A new atherosclerosis-associated antigen that is target of protective antibodies (Nature 2020)
The B Cell Biology Lab welcomes enthusiastic and creative scientists to join the crew, contact us!