Molecular Mechanics of the Cardiovascular System

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We are a multidisciplinary team of scientists who investigate how mechanical forces determine muscle function at the molecular, cellular, tissue and organismal levels. Our motivation is to improve the understanding, diagnosis and treatment of cardiovascular and musculoskeletal diseases. At the same time, we train scientists, awake vocations in science and contribute to strengthen and disseminate the scientific culture.

In the “Know more” page you will find more information about our current projects. Click on the “Interesting info” and “Downloads” sections for interesting links and files of the methods we use, lectures, seminars and talks. For updates and news, follow Jorge in twitter @AlegreCebollada.

News

News:

  • June 2021. We review the state of the art of protein hydrogels an their mechanical properties in our latest publication.
  • June 2021. Jorge is appointed to the Spanish Young Academy.
  • May 2021. Our work examining the nanomechanics of mutant proteins that cause hypertrophic cardiomyopathy has been published in ACS Nano.
  • May 2021. In a paper in JBC we report on molecular phenotypes that identify mutations that cause hypertrophic cardiomyopathy. The paper has been selected as Editors’ Pick. Related to this work, check our commentary in Genetics in Medicine.
  • March 2021. Jorge is selected as a winner of the 2021 Michèle Auger Award presented by the journal Biophysical Reviews.
  • December 2020. Our project ProtMechanics-Live has been awarded an ERC-consolidator grant. Many thanks to the many people that are contributing to our quest to understand the role of protein mechanics in vivo!
  • September 2020. In our latest preprint, we describe that titin cysteines are oxidized in basal conditions, contributing to the mechanical function of cardiomyocytes. In collaboration with Dr. García-Pavía, we show that mutations in these cysteines cause dilated cardiomyopathy.
  • April 2020. We report a method to examine and interfere with nanomechanical properties of native proteins. Check out the paper here.

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