Molecular Mechanics of the Cardiovascular System

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We are a multidisciplinary team of scientists who investigate how mechanical forces determine muscle function at the molecular, cellular, tissue and organismal levels. Our motivation is to improve the understanding, diagnosis and treatment of cardiovascular and musculoskeletal diseases. At the same time, we train scientists, awake vocations in science and contribute to strengthen and disseminate the scientific culture.

In the “Know more” page you will find more information about our current projects. Click on the “Interesting info” and “Downloads” sections for interesting links and files of the methods we use, lectures, seminars and talks. For updates and news, follow Jorge in twitter @AlegreCebollada.

News

News:

  • September 2020. Our work examining the nanomechanics of mutant proteins that cause hypertrophic cardiomyopathy is now available on biorxiv.
  • September 2020. In our latest preprint, we describe that titin cysteines are oxidized in basal conditions, contributing to the mechanical function of cardiomyocytes. In collaboration with Dr. García-Pavía, we show that mutations in these cysteines cause dilated cardiomyopathy.
  • May 2020. Our new preprint in medRxiv reports on how to identify mutations that cause hypertrophic cardiomyopathy.
  • April 2020. We report a method to examine and interfere with nanomechanical properties of native proteins. Check out the paper here.
  • December 2019. The laboratory is recommended for promotion by CNIC’s scientific advisory board.
  • December 2019. We publish a collaborative work with Miguel Ángel del Pozo’s group on cell mechanotransduction mediated by Abl. Carla led our contribution. Paper here.
  • January 2020. We report on the functional assessment of a new variant of MYBPC3 associated to hypertrophic cardiomyopathy. Published in JCTR. Congratulations Maria Rosaria. Preprint available from here.
  • August 2019. Check out our paper on concurrent atomic force spectroscopy. Single-molecule AFM made faster and more accurate. Carolina has been awarded best Master’s Thesis for this work.

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