Molecular Mechanics of the Cardiovascular System

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    • December 2022. Andra signs her Junior Leader Fellowship funded by La Caixa Foundation.
    • October 2022. Inés is awarded the EMBO Best Young Investigator Talk Prize at the EMBO Workshop on Thiol Oxidation in Biology in Sant Feliu de Guixols.
    • February 2022. Have a look at our extensive review on Hypertrophic Cardiomyopathy (HCM) and the specific role of cMyBP-C.
    • August 2021. Jorge’s review on protein nanomechanics is out in Biophysical Reviews following his designation as the recipient of the 2021 Michèle Auger Award.
    • June 2021. We review the state of the art of protein hydrogels an their mechanical properties in our latest publication.
    • February 2021. We have published the main outcome of our ERA-CVD Minotaur consortium: a potential new treatment for heart failure. Check out the paper here.
    • February 2021: Inés has been selected as a winner of the Student Research Achievement Award at the 65th Biophysical Society Meeting. She presented her work on the structure of a titin domain involved in dilated cardiomyopathy.
    • April 2020. We report a method to examine and interfere with nanomechanical properties of native proteins. Check out the paper here.
    • January 2020. We report on the functional assessment of a new variant of MYBPC3 associated to hypertrophic cardiomyopathy. Published in JCTR. Congratulations Maria Rosaria. Preprint available from here.
    • December 2019. The laboratory is recommended for promotion by CNIC’s scientific advisory board.
    • December 2019. We publish a collaborative work with Miguel Ángel del Pozo’s group on cell mechanotransduction mediated by Abl. Carla led our contribution. Paper here.
    • October 2019. The Spanish Biochemical Society (SEBBM) features Jorge in their outreach section. Publication can be accessed from here.
    • August 2019. Check out our paper on concurrent atomic force spectroscopy. Single-molecule AFM made faster and more accurate. Carolina has been awarded best Master’s Thesis for this work.
    • Summer 2019. Congratulations to David Sánchez and Inés Martínez for getting the maximum qualification for their Degree Thesis.
    • January 2019. Check out our review on the redox regulation of titin mechanics.
    • January 2019. We start the collaborative project Tec4Bio, funded by the Regional Government of Madrid and coordinated by F. Moreno-Herrero at CNB. We’ll develop new technologies to study biology and human diseases.
    • October 2018. Congratulations Carla and Ángel for your EMBO and Boehringer Travel Fellowships to visit the labs of Prof. Vunjak-Novakovic (Columbia U.) and Prof. Linke (Muenster U.)
    • September 2018. We host at CNIC the midterm meeting of MINOTAUR, a European Consortium funded by ERA-CVD to study metabolic therapies against heart failure.
    • August 2018. Jorge is awarded the element Arsenic in the periodic table of younger chemists of the IUPAC.
    • July 2018. We are part of the Spanish Network of Excellence in Mechanobiology, alongside terrific cell biologists, and theoreticians.
    • February 2018. Elías will present our latest results about titin oxidation at the Biophysical Society Meeting (San Francisco, US).
    • January 2018. Our paper describing disulfide isomerization as a new mechanism of titin elasticity is out.
    • January 2018. We welcome Ángel Fernández-Trasancos, a postdoctoral scientist who will lead generation of novel animal models to study protein mechanobiology in heart disease.
    • December 2017. We have very good news regarding our application to the Spanish Grant Program. We will get a fully funded PhD fellowship (FPI) in 2018. If interested in applying, contact Jorge.
    • October 2017. We are happy to be part of MINOTAUR, a European Consortium who will be funded by ERA-CVD to study metabolic therapies against heart failure.
    • September 2017. We will be presenting our latest results about titin oxidation at the European Muscle Conference in Potsdam, Germany.
    • July 2017. We collaborate to define the evolution of titin in the vertebrate lineage, just published in  Nature Structural and Molecular Biology.
    • June 2017: we welcome Inés Martínez and David Sánchez our cicerone students for the summer.
    • May 2017. We participate in the science fair organized by FECYT. Take a second to admire our handcrafted sarcomere designed by Natalia. Titin is definitely a molecular spring!
    • November 2016. We participated in several activities of Madrid’s Science Week. We saw fermentation in action and chromatography at local school CEIP Tagore.
    • November 2016. The VI CNIC conference “Mechanical Forces in Physiology and Disease” was a success! We have learned a good deal from world leaders in many aspects of mechanobiology. Thank you all for coming!
    • November 2016. We welcome PhD student Maria Rosaria Pricolo from Università degli Studi di Napoli "Federico II" who will spend six months with us investigating pathogenic mechanisms in cardiomyopathies.