Selected publications

Suay-Corredera C, Pricolo MR, Velázquez-Carreras D, Pathak D, Nandwani N, Pimenta-Lopes C, Sánchez-Ortiz D, Urrutia-Irazabal I, Vilches S, Dominguez F, Frisso G, Monserrat L, García-Pavía P, de Sancho D, Spudich JA, Ruppel KM, Herrero-Galán E, Alegre-Cebollada J Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy ACS NANO (2021) Jun 2 [Epub ahead of print]
Suay-Corredera C, Pricolo MR, Herrero-Galán E, Velázquez-Carreras D, Sánchez-Ortiz D, García-Giustiniani D, Delgado J, Galano-Frutos JJ, García-Cebollada H, Vilches S, Domínguez F, Molina MS, Barriales-Villa R, Frisso G, Sancho J, Serrano L, García-Pavía P, Monserrat L, Alegre-Cebollada J Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy J Biol Chem (2021) :100854
Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt JK, Voglhuber J, Pricolo MR, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer SJ, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani CN, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer PP, von Maltzahn J, Mühlfeld C, Krüger M, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira AF, Lourenço AP, Alegre-Cebollada J, Kiechl S, Linke WA, Kroemer G, Sedej S Nicotinamide for the treatment of heart failure with preserved ejection fraction Sci Transl Med (2021) 13
Alegre-Cebollada J Protein nanomechanics in biological context Biophys Rev (2021) 13:435–454
Link to the journal
Nicolas-Avila JA, Lechuga-Vieco AV, Esteban-Martinez L, Sanchez-Diaz M, Diaz-Garcia E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martinez-de-Mena R, Castejon-Vega B, Pun-Garcia A, Traves PG, Bonzon-Kulichenko E, Garcia-Marques F, Cusso L, N AG, Gonzalez-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzman G, Larrazabal J, Herrero-Galan E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Munoz-Canoves P, Ibanez B, Torres M, Ng LG, Priori SG, Bueno H, Vazquez J, Cordero MD, Bernal JA, Enriquez JA, Hidalgo A A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart Cell (2020) 183:94-109
Link to the full text in Repisalud
Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Fernández JM, Linke WA, Alegre-Cebollada J A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues Nat Commun (2020) 11:2060
Link to the full text in Repisalud
Herrero-Galán E, Domínguez F, Martínez-Martín I, Sánchez-González C, Vicente N, Lalaguna L, Bonzón-Kulichenko E, Calvo E, González-López E, Cobo-Marcos M, Bornstein B, Briceño A, Ochoa JP, Garcia-Aznar JM, Suay-Corredera C, Pricolo MR, Fernández-Trasancos Á, Velázquez-Carreras D, Badía Careaga C, Prados B, Gutiérrez-Agüera F, Abdellatif M, Sedej S, Rainer PP, Giganti D, Giovinazzo G, Bernal JA, Pérez-Jiménez R, Rasmussen TB, Hey TM, Vivo-Ortega I, Piqueras-Flores J, Lara-Pezzi E, Vázquez J, Garcia-Pavia P, Alegre-Cebollada J Conserved cysteines in titin sustain the mechanical function of cardiomyocytes bioRxiv (2020) 9:282913
Link to bioRxiv
Echarri A, Pavon DM, Sanchez S, Garcia-Garcia M, Calvo E, Huerta-Lopez C, Velazquez-Carreras D, Viaris de Lesegno C, Ariotti N, Lazaro-Carrillo A, Strippoli R, De Sancho D, Alegre-Cebollada J, Lamaze C, Parton RG, Del Pozo MA An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation Nat Commun (2019) 10:5828
Link to the full text in Repisalud
Herrero-Galan E, Martinez-Martin I, Alegre-Cebollada J. Redox regulation of protein nanomechanics in health and disease: lessons from titin. Redox Biol (2019) 21:101074
Link to the full text in Repisalud
Pimenta-Lopes C, Suay-Corredera C, Velázquez-Carreras D, Sánchez-Ortiz D, Alegre-Cebollada J. Concurrent atomic force spectroscopy. Comms Phys (2019) 2:91
Link to the full text in Repisalud
Giganti D, Yan K, Badilla CL, Fernandez JM, Alegre-Cebollada J. Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity. Nat Commun (2018) 9:185
Link to the full text in Repisalud
Manteca A, Schonfelder J, Alonso-Caballero A, Fertin MJ, Barruetabena N, Faria BF, Herrero-Galan E, Alegre-Cebollada J, De Sancho D, Perez-Jimenez R. Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins. Nat Struct Mol Biol (2017) 24:652-7
Link to the full text in Repisalud
Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernandez JM. CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proc Natl Acad Sci U S A (2016) 113:2490-5
Saqlain F, Popa I, Fernández JM, Alegre‐Cebollada J A Novel Strategy for Utilizing Voice Coil Servoactuators in Tensile Tests of Low Volume Protein Hydrogels Macromol Mater Eng (2015) 300:369-76
Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding Cell (2014) 156:1234-46
Solsona C, Kahn TB, Badilla CL, Alvarez-Zaldiernas C, Blasi J, Fernandez JM, Alegre-Cebollada J. Altered Thiol Chemistry in Human Amyotrophic Lateral Sclerosis-linked Mutants of Superoxide Dismutase 1. J Biol Chem (2014) 289:26722-32
Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM Protein folding drives disulfide formation Cell (2012) 151:794-806
Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM. Direct observation of disulfide isomerization in a single protein. Nat Chem (2011) 3:882-7