Publicaciones seleccionadas

    Vicanolo T, Özcan A, Li JL, Huerta-López C, Ballesteros I, Rubio-Ponce A, Dumitru AC, Nicolás-Ávila JÁ, Molina-Moreno M, Reyes-Gutierrez P, Johnston AD, Martone C, Greto E, Quílez-Alvarez A, Calvo E, Bonzon-Kulichenko E, Álvarez-Velez R, Chooi MY, Kwok I, González-Bermúdez B, Malleret B, Espinosa FM, Zhang M, Wang YL, Sun D, Zhen Chong S, El-Armouche A, Kim KK, Udalova IA, Greco V, Garcia R, Vázquez J, Dopazo A, Plaza GR, Alegre-Cebollada J, Uderhardt S, Ng LG, Hidalgo A. Matrix-producing neutrophils populate and shield the skin. Nature (2025) 641:740-748
    Silva-Rojas R, Vicente N, Gavilán-Herrera M, Labrador-Cantarero V, Sicilia J, Giménez-Sáez O, Dumitru AC, Sánchez MI, Gato-Vilaseca M, Velázquez-Carreras D, López JA, Vázquez J, Herrero-Galán E, López-Unzu MA, Pricolo MR, Alegre-Cebollada J. Mechanically knocking out titin reveals protein tension loss as a trigger of muscle disease. Nat Biomed Eng (2025) Jun 5 [Epub ahead of print]
    Huerta-López C, Clemente-Manteca A, Velázquez-Carreras D, Espinosa FM, Sanchez JG, Martínez-Del-Pozo Á, García-García M, Martín-Colomo S, Rodríguez-Blanco A, Esteban-González R, Martín-Zamora FM, Gutierrez-Rus LI, Garcia R, Roca-Cusachs P, Elosegui-Artola A, Del Pozo MA, Herrero-Galán E, Sáez P, Plaza GR, Alegre-Cebollada J. Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing, Sci Adv (2024) 10:eadf9758
    Martinez-Martin I, Crousilles A, Ochoa JP, Velazquez-Carreras D, Mortensen SA, Herrero-Galan E, Delgado J, Dominguez F, Garcia-Pavia P, de Sancho D, Wilmanns M, Alegre-Cebollada J. Titin domains with reduced core hydrophobicity cause dilated cardiomyopathy. Cell Rep (2023) Nov 23 [Epub ahead of print]
    Link to the full text in Repisalud
    Herrero-Galán, E., Martínez-Martín, I., Sánchez-González, C., Vicente, N., Bonzón-Kulichenko, E., Calvo, E., Suay-Corredera, C., Pricolo, M. R., Fernández-Trasancos, Á., Velázquez-Carreras, D., Careaga, C. B., Abdellatif, M., Sedej, S., Rainer, P. P., Giganti, D., Pérez-Jiménez, R., Vázquez, J., & Alegre-Cebollada, J. Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics Redox Biol (2022) 52
    Link to the full text in Repisalud
    Suay-Corredera C, Alegre-Cebollada J. The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP-C. FEBS Lett (2022) 596:703-746
    Link to the full text in Repisalud
    Suay-Corredera C, Pricolo MR, Velázquez-Carreras D, Pathak D, Nandwani N, Pimenta-Lopes C, Sánchez-Ortiz D, Urrutia-Irazabal I, Vilches S, Dominguez F, Frisso G, Monserrat L, García-Pavía P, de Sancho D, Spudich JA, Ruppel KM, Herrero-Galán E, Alegre-Cebollada J Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy ACS NANO (2021) Jun 2 [Epub ahead of print]
    Link to the full text in Repisalud
    Suay-Corredera C, Alegre-Cebollada J Correspondence on "Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation" by Thompson et al GENET MED (2021) Jun 12 [Epub ahead of print]
    Suay-Corredera C, Pricolo MR, Herrero-Galán E, Velázquez-Carreras D, Sánchez-Ortiz D, García-Giustiniani D, Delgado J, Galano-Frutos JJ, García-Cebollada H, Vilches S, Domínguez F, Molina MS, Barriales-Villa R, Frisso G, Sancho J, Serrano L, García-Pavía P, Monserrat L, Alegre-Cebollada J Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy J Biol Chem (2021) :100854
    Alegre-Cebollada J Protein nanomechanics in biological context Biophys Rev (2021) 13:435–454
    Link to the journal
    Nicolas-Avila JA, Lechuga-Vieco AV, Esteban-Martinez L, Sanchez-Diaz M, Diaz-Garcia E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martinez-de-Mena R, Castejon-Vega B, Pun-Garcia A, Traves PG, Bonzon-Kulichenko E, Garcia-Marques F, Cusso L, N AG, Gonzalez-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzman G, Larrazabal J, Herrero-Galan E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Munoz-Canoves P, Ibanez B, Torres M, Ng LG, Priori SG, Bueno H, Vazquez J, Cordero MD, Bernal JA, Enriquez JA, Hidalgo A A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart Cell (2020) 183:94-109
    Link to the full text in Repisalud
    Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Fernández JM, Linke WA, Alegre-Cebollada J A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues Nat Commun (2020) 11:2060
    Link to the full text in Repisalud
    Pricolo MR*, Herrero-Galan E, Mazzaccara C, Losi MA, Alegre-Cebollada J*, Frisso G *(MRP and JAC are both co-corresponding authors) Protein Thermodynamic Destabilization in the Assessment of Pathogenicity of a Variant of Uncertain Significance in Cardiac Myosin Binding Protein C J Cardiovasc Transl Res (2020) 13:867-877
    Link to the full text in Repisalud
    Herrero-Galan E, Martinez-Martin I, Alegre-Cebollada J. Redox regulation of protein nanomechanics in health and disease: lessons from titin. Redox Biol (2019) 21:101074
    Link to the full text in Repisalud
    Pimenta-Lopes C, Suay-Corredera C, Velázquez-Carreras D, Sánchez-Ortiz D, Alegre-Cebollada J. Concurrent atomic force spectroscopy. Comms Phys (2019) 2:91
    Link to the full text in Repisalud
    Giganti D, Yan K, Badilla CL, Fernandez JM, Alegre-Cebollada J. Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity. Nat Commun (2018) 9:185
    Link to the full text in Repisalud
    Manteca A, Schonfelder J, Alonso-Caballero A, Fertin MJ, Barruetabena N, Faria BF, Herrero-Galan E, Alegre-Cebollada J, De Sancho D, Perez-Jimenez R. Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins. Nat Struct Mol Biol (2017) 24:652-7
    Link to the full text in Repisalud
    Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding Cell (2014) 156:1234-46
    Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM Protein folding drives disulfide formation Cell (2012) 151:794-806
    Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM. Direct observation of disulfide isomerization in a single protein. Nat Chem (2011) 3:882-7

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