Publicaciones seleccionadas

Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt JK, Voglhuber J, Pricolo MR, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer SJ, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani CN, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer PP, von Maltzahn J, Mühlfeld C, Krüger M, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira AF, Lourenço AP, Alegre-Cebollada J, Kiechl S, Linke WA, Kroemer G, Sedej S Nicotinamide for the treatment of heart failure with preserved ejection fraction Sci Transl Med (2021) 13
Nicolas-Avila JA, Lechuga-Vieco AV, Esteban-Martinez L, Sanchez-Diaz M, Diaz-Garcia E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martinez-de-Mena R, Castejon-Vega B, Pun-Garcia A, Traves PG, Bonzon-Kulichenko E, Garcia-Marques F, Cusso L, N AG, Gonzalez-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzman G, Larrazabal J, Herrero-Galan E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Munoz-Canoves P, Ibanez B, Torres M, Ng LG, Priori SG, Bueno H, Vazquez J, Cordero MD, Bernal JA, Enriquez JA, Hidalgo A A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart Cell (2020) 183:94-109
Link to the full text in Repisalud
Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Fernández JM, Linke WA, Alegre-Cebollada J A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues Nat Commun (2020) 11:2060
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Herrero-Galán E, Domínguez F, Martínez-Martín I, Sánchez-González C, Vicente N, Lalaguna L, Bonzón-Kulichenko E, Calvo E, González-López E, Cobo-Marcos M, Bornstein B, Briceño A, Ochoa JP, Garcia-Aznar JM, Suay-Corredera C, Pricolo MR, Fernández-Trasancos Á, Velázquez-Carreras D, Badía Careaga C, Prados B, Gutiérrez-Agüera F, Abdellatif M, Sedej S, Rainer PP, Giganti D, Giovinazzo G, Bernal JA, Pérez-Jiménez R, Rasmussen TB, Hey TM, Vivo-Ortega I, Piqueras-Flores J, Lara-Pezzi E, Vázquez J, Garcia-Pavia P, Alegre-Cebollada J Conserved cysteines in titin sustain the mechanical function of cardiomyocytes bioRxiv (2020) 9:282913
Link to bioRxiv
Suay-Corredera C, Pricolo MR, Velázquez-Carreras D, Pimenta-Lopes C, Sánchez-Ortiz D, Urrutia-Irazabal I, Vilches S, Dominguez F, Frisso G, Monserrat L, García-Pavía P, Herrero-Galán E, Alegre-Cebollada J Nanomechanical phenotypes in cMyBP-C mutants that cause hypertrophic cardiomyopathy bioRxiv (2020) 9:304618
Link to bioRxiv
Suay-Corredera C, Pricolo MR, Herrero-Galan E, Velazquez-Carreras D, Sanchez-Ortiz D, Garcia-Giustiniani D, Delgado J, Galano-Frutos JJ, Garcia-Cebollada H, Vilches S, Dominguez F, Sabater Molina M, Barriales-Villa R, Frisso G, Sancho J, Serrano L, Garcia-Pavia P, Monserrat L, Alegre-Cebollada J Protein haploinsufficiency drivers identify MYBPC3 mutations that cause hypertrophic cardiomyopathy medRxiv (2020) 2020:20087726
Link to medRxiv
Echarri A, Pavon DM, Sanchez S, Garcia-Garcia M, Calvo E, Huerta-Lopez C, Velazquez-Carreras D, Viaris de Lesegno C, Ariotti N, Lazaro-Carrillo A, Strippoli R, De Sancho D, Alegre-Cebollada J, Lamaze C, Parton RG, Del Pozo MA An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation Nat Commun (2019) 10:5828
Link to the full text in Repisalud
Herrero-Galan E, Martinez-Martin I, Alegre-Cebollada J. Redox regulation of protein nanomechanics in health and disease: lessons from titin. Redox Biol (2019) 21:101074
Link to the full text in Repisalud
Pimenta-Lopes C, Suay-Corredera C, Velázquez-Carreras D, Sánchez-Ortiz D, Alegre-Cebollada J. Concurrent atomic force spectroscopy. Comms Phys (2019) 2:91
Link to the full text in Repisalud
Giganti D, Yan K, Badilla CL, Fernandez JM, Alegre-Cebollada J. Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity. Nat Commun (2018) 9:185
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Manteca A, Schonfelder J, Alonso-Caballero A, Fertin MJ, Barruetabena N, Faria BF, Herrero-Galan E, Alegre-Cebollada J, De Sancho D, Perez-Jimenez R. Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins. Nat Struct Mol Biol (2017) 24:652-7
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Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernandez JM. CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proc Natl Acad Sci U S A (2016) 113:2490-5
Saqlain F, Popa I, Fernández JM, Alegre‐Cebollada J A Novel Strategy for Utilizing Voice Coil Servoactuators in Tensile Tests of Low Volume Protein Hydrogels Macromol Mater Eng (2015) 300:369-76
Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding Cell (2014) 156:1234-46
Solsona C, Kahn TB, Badilla CL, Alvarez-Zaldiernas C, Blasi J, Fernandez JM, Alegre-Cebollada J. Altered Thiol Chemistry in Human Amyotrophic Lateral Sclerosis-linked Mutants of Superoxide Dismutase 1. J Biol Chem (2014) 289:26722-32
Popa I, Berkovich R, Alegre-Cebollada J, Badilla CL, Rivas-Pardo JA, Taniguchi Y, Kawakami M, Fernandez JM. Nanomechanics of HaloTag tethers J Am Chem Soc (2013) 135:12762-71
Popa I, Kosuri P, Alegre-Cebollada J, Garcia-Manyes S, Fernandez JM. Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy Nat Protocol (2013) 8:1261-76
Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM Protein folding drives disulfide formation Cell (2012) 151:794-806
Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM. Direct observation of disulfide isomerization in a single protein. Nat Chem (2011) 3:882-7