Publicaciones seleccionadas

Martinez-Martin I, Crousilles A, Ochoa JP, Velazquez-Carreras D, Mortensen SA, Herrero-Galan E, Delgado J, Dominguez F, Garcia-Pavia P, de Sancho D, Wilmanns M, Alegre-Cebollada J. Titin domains with reduced core hydrophobicity cause dilated cardiomyopathy. Cell Rep (2023) Nov 23 [Epub ahead of print]
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Herrero-Galán, E., Martínez-Martín, I., Sánchez-González, C., Vicente, N., Bonzón-Kulichenko, E., Calvo, E., Suay-Corredera, C., Pricolo, M. R., Fernández-Trasancos, Á., Velázquez-Carreras, D., Careaga, C. B., Abdellatif, M., Sedej, S., Rainer, P. P., Giganti, D., Pérez-Jiménez, R., Vázquez, J., & Alegre-Cebollada, J. Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics Redox Biol (2022) 52
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Suay-Corredera C, Pricolo MR, Velázquez-Carreras D, Pathak D, Nandwani N, Pimenta-Lopes C, Sánchez-Ortiz D, Urrutia-Irazabal I, Vilches S, Dominguez F, Frisso G, Monserrat L, García-Pavía P, de Sancho D, Spudich JA, Ruppel KM, Herrero-Galán E, Alegre-Cebollada J Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy ACS NANO (2021) Jun 2 [Epub ahead of print]
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Suay-Corredera C, Pricolo MR, Herrero-Galán E, Velázquez-Carreras D, Sánchez-Ortiz D, García-Giustiniani D, Delgado J, Galano-Frutos JJ, García-Cebollada H, Vilches S, Domínguez F, Molina MS, Barriales-Villa R, Frisso G, Sancho J, Serrano L, García-Pavía P, Monserrat L, Alegre-Cebollada J Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy J Biol Chem (2021) :100854
Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt JK, Voglhuber J, Pricolo MR, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer SJ, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani CN, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer PP, von Maltzahn J, Mühlfeld C, Krüger M, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira AF, Lourenço AP, Alegre-Cebollada J, Kiechl S, Linke WA, Kroemer G, Sedej S Nicotinamide for the treatment of heart failure with preserved ejection fraction Sci Transl Med (2021) 13
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Alegre-Cebollada J Protein nanomechanics in biological context Biophys Rev (2021) 13:435–454
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Nicolas-Avila JA, Lechuga-Vieco AV, Esteban-Martinez L, Sanchez-Diaz M, Diaz-Garcia E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martinez-de-Mena R, Castejon-Vega B, Pun-Garcia A, Traves PG, Bonzon-Kulichenko E, Garcia-Marques F, Cusso L, N AG, Gonzalez-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzman G, Larrazabal J, Herrero-Galan E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Munoz-Canoves P, Ibanez B, Torres M, Ng LG, Priori SG, Bueno H, Vazquez J, Cordero MD, Bernal JA, Enriquez JA, Hidalgo A A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart Cell (2020) 183:94-109
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Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Fernández JM, Linke WA, Alegre-Cebollada J A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues Nat Commun (2020) 11:2060
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Pricolo MR*, Herrero-Galan E, Mazzaccara C, Losi MA, Alegre-Cebollada J*, Frisso G *(MRP and JAC are both co-corresponding authors) Protein Thermodynamic Destabilization in the Assessment of Pathogenicity of a Variant of Uncertain Significance in Cardiac Myosin Binding Protein C J Cardiovasc Transl Res (2020) 13:867-877
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Echarri A, Pavon DM, Sanchez S, Garcia-Garcia M, Calvo E, Huerta-Lopez C, Velazquez-Carreras D, Viaris de Lesegno C, Ariotti N, Lazaro-Carrillo A, Strippoli R, De Sancho D, Alegre-Cebollada J, Lamaze C, Parton RG, Del Pozo MA An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation Nat Commun (2019) 10:5828
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Herrero-Galan E, Martinez-Martin I, Alegre-Cebollada J. Redox regulation of protein nanomechanics in health and disease: lessons from titin. Redox Biol (2019) 21:101074
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Pimenta-Lopes C, Suay-Corredera C, Velázquez-Carreras D, Sánchez-Ortiz D, Alegre-Cebollada J. Concurrent atomic force spectroscopy. Comms Phys (2019) 2:91
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Giganti D, Yan K, Badilla CL, Fernandez JM, Alegre-Cebollada J. Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity. Nat Commun (2018) 9:185
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Manteca A, Schonfelder J, Alonso-Caballero A, Fertin MJ, Barruetabena N, Faria BF, Herrero-Galan E, Alegre-Cebollada J, De Sancho D, Perez-Jimenez R. Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins. Nat Struct Mol Biol (2017) 24:652-7
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Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernandez JM. CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proc Natl Acad Sci U S A (2016) 113:2490-5
Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding Cell (2014) 156:1234-46
Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM Protein folding drives disulfide formation Cell (2012) 151:794-806
Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM. Direct observation of disulfide isomerization in a single protein. Nat Chem (2011) 3:882-7