Selected publications

Mühleder S, Benedito R. An RNA helicase swirls in lymphangiogenesis Nat Cell Biol (2021) 23:1109-1110
Mühleder S, Fernández-Chacón M, Garcia-Gonzalez I, Benedito R Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology Cell Mol Life Sci (2021) 78:1329-54
Fernández-Chacón M, García-González I, Mühleder S, Benedito R Role of Notch in endothelial biology Angiogenesis (2021) 24:237-50
Garcia-Gonzalez I, Benedito R Intricacies of conditional genetics in vascular biology CURR OPIN HEMATOL (2021) 28:189-197
Luo W, Garcia-Gonzalez I, Fernández-Chacón M, Casquero-Garcia V, Sanchez-Muñoz MS, Mühleder S, Garcia-Ortega L, Andrade J, Potente M, Benedito R Arterialization requires the timely suppression of cell growth Nature (2020) 589:437-441
Laruy B, Garcia-Gonzalez I, Casquero-Garcia V, Benedito R. Endothelial-to-hematopoietic transition is induced by Notch glycosylation and upregulation of Mycn bioRxiv (2020) :295238
Link to bioRxiv
Garcia-Gonzalez I, Mühleder S, Fernández-Chacón M, Benedito R Genetic Tools to Study Cardiovascular Biology Front Physiol (2020) 11:1084
Link to the full text in Repisalud
Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Kruger M, Benedito R, Dikic I, Potente M. Deubiquitinase USP10 regulates Notch signaling in the endothelium Science (2019) 364:188-193
Link to the full text in Repisalud
Pontes-Quero S, Fernandez-Chacón M, Lou W, Lunella FF, Casquero-Garcia V, Garcia-Gonzalez I, Hermoso A, Ferreira Rocha S, Bansal M, Benedito R High mitogenic stimulation arrests angiogenesis Nat Commun (2019) 10:2016
Link to the full text in Repisalud
Fernandez-Chacon M, Casquero-Garcia V, Lou W, Lunella FF, Ferreira Rocha S, Del Olmo-Cabrera S, Benedito R iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications Nat Commun (2019) 10:2262
Link to the full text in Repisalud
Menchero S, Rollan I, Lopez-Izquierdo A, Andreu MJ, Sainz de Aja J, Kang M, Adan J, Benedito R, Rayon T, Hadjantonakis AK, Manzanares M Transitions in cell potency during early mouse development are driven by Notch eLife (2019) 8:e42930
Link to the full text in Repisalud
Poulsen LC, Edelmann RJ, Kruger S, Dieguez-Hurtado R, Shah A, Stav-Noraas TE, Renzi A, Szymanska M, Wang J, Ehling M, Benedito R, Kasprzycka M, Baekkevold E, Sundnes O, Midwood KS, Scott H, Collas P, Siebel CW, Adams RH, Haraldsen G, Sundlisaeter E, Hol J. Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers. Arterioscler Thromb Vasc Biol (2018) 38:854-69
Pontes-Quero S, Heredia L, Casquero-Garcia V, Fernandez-Chacon M, Luo W, Hermoso A, Bansal M, Garcia-Gonzalez I, Sanchez-Munoz MS, Perea JR, Galiana-Simal A, Rodriguez-Arabaolaza I, Del Olmo-Cabrera S, Rocha SF, Criado-Rodriguez LM, Giovinazzo G, Benedito R. Dual ifgMosaic: A Versatile Method for Multispectral and Combinatorial Mosaic Gene-Function Analysis. Cell (2017) 170:800-14
Link to the full text in Repisalud
D'Amato G, Luxan G, Del Monte-Nieto G, Martinez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jimenez-Borreguero LJ, de la Pompa JL. Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol (2016) 18:7-20
Bernier-Latmani J, Cisarovsky C, Demir CS, Bruand M, Jaquet M, Davanture S, Ragusa S, Siegert S, Dormond O, Benedito R, Radtke F, Luther SA, Petrova TV. DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest (2015) 125:4572-86
Rocha SF, Schiller M, Jing D, Li H, Butz S, Vestweber D, Biljes D, Drexler HC, Nieminen-Kelha M, Vajkoczy P, Adams S, Benedito R, Adams RH. Esm1 Modulates Endothelial Tip Cell Behavior and Vascular Permeability by Enhancing VEGF Bioavailability. Circ Res (2014) 115:581-90
Wang L, Benedito R, Bixel MG, Zeuschner D, Stehling M, Sävendahl L, Haigh JJ, Snippert H, Clevers H, Breier G, Kiefer F, Adams RH. Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J (2013) 32:219-30
Benedito R, Hellström M. Notch as a hub for signaling in angiogenesis. Exp Cell Res (2013) 319:1281-8
Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams RH. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling Nature (2012) 484:110-4
Benedito R, Roca C, Sörensen I, Adams S, Gossler A, Fruttiger M, Adams RH. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis Cell (2009) 137:1124-35