Selected publications

Thottacherry JJ, Kosmalska AJ, Kumar A, Vishen AS, Elosegui-Artola A, Pradhan S, Sharma S, Singh PP, Guadamillas MC, Chaudhary N, Vishwakarma R, Trepat X, Del Pozo MA, Parton RG, Rao M, Pullarkat P, Roca-Cusachs P, Mayor S. Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells. Nat Commun (2018) 9:4217
Pellinen T, Blom S, Sanchez S, Valimaki K, Mpindi JP, Azegrouz H, Strippoli R, Nieto R, Viton M, Palacios I, Turkki R, Wang Y, Sanchez-Alvarez M, Nordling S, Butzow A, Mirtti T, Rannikko A, Montoya MC, Kallioniemi O, Del Pozo MA. ITGB1-dependent upregulation of Caveolin-1 switches TGFbeta signalling from tumour-suppressive to oncogenic in prostate cancer. Sci Rep (2018) 8:2338
Moreno-Vicente R, Pavon DM, Martin-Padura I, Catala-Montoro M, Diez-Sanchez A, Quilez-Alvarez A, Lopez JA, Sanchez-Alvarez M, Vazquez J, Strippoli R, Del Pozo MA. Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP. Cell Rep (2018) 25:1622-35
Minguet S, Kläsener K, Schaffer AM, Fiala GJ, Osteso-Ibánez T, Raute K, Navarro-Lérida I, Hartl FA, Seidl M, Reth M, Del Pozo MA. Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance Nat Immunol (2017) 18:1150-9
Schonle A, Hartl FA, Mentzel J, Noltner T, Rauch KS, Prestipino A, Wohlfeil SA, Apostolova P, Hechinger AK, Melchinger W, Fehrenbach K, Guadamillas MC, Follo M, Prinz G, Ruess AK, Pfeifer D, Del Pozo MA, Schmitt-Graeff A, Duyster J, Hippen KI, Blazar BR, Schachtrup K, Minguet S, Zeiser R. Caveolin-1 regulates TCR signal strength and regulatory T cell differentiation into alloreactive T cells. Blood (2016) 127:1930-9
Sala-Vila A*, Navarro-Lerida I*, Sanchez-Alvarez M, Bosch M, Calvo C, Lopez JA, Calvo E, Ferguson C, Giacomello M, Serafini A, Scorrano L, Enriquez JA, Balsinde J, Parton RG, Vazquez J, Pol A, Del Pozo MA. (*ASV and INL contributed equally) Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice. Sci Rep (2016) 6:27351
Navarro-Lérida I, Pellinen T, Sánchez SA, Guadamillas MC, Wang Y, Mirtti T, Calvo, Del Pozo MA. Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion Dev Cell (2015) 32:318-334
Echarri A, Del Pozo MA. Caveolae - mechanosensitive membrane invaginations linked to actin filaments. J Cell Sci (2015) 128:2747-58
Strippoli R, Loureiro J, Moreno V, Benedicto I, Perez Lozano ML, Barreiro O, Pellinen T, Minguet S, Foronda M, Osteso MT, Calvo E, Vazquez J, Lopez Cabrera M, Del Pozo MA Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis EMBO Mol Med (2015) 7:102-23
Parton RG, Del Pozo MA. Caveolae as plasma membrane sensors, protectors and organizers. Nat Rev Mol Cell Biol (2013) 14:98-112
Navarro-Lérida I, Sánchez-Perales S, Calvo M, Rentero C, Zheng Y, Enrich C, Del Pozo MA. A palmitoylation switch mechanism regulates Rac1 function and membrane organization. EMBO J (2012) 31:534-51
Echarri A, Del Pozo MA. Caveolae Curr Biol (2012) 22:R114-6
Echarri A, Muriel O, Pavón DM, Azegrouz H, Escolar F, Terrón MC, Sanchez-Cabo F, Martínez F, Montoya MC, Llorca O, Del Pozo MA. Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1 J Cell Sci (2012) 125:3097-113
Goetz JG*, Minguet S*, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibáñez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, Sánchez-Mateos P, Cukierman E, Del Pozo MA (JGG and SM contributed equally) Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis Cell (2011) 146:148-63
Muriel O, Echarri A, Hellriegel C, Pavón DM, Beccari L, Del Pozo MA. Phosphorylated filamin A regulates actin-linked caveolae dynamics. J Cell Sci (2011) 124:2763-76
Guadamillas MC*, Cerezo A*, Del Pozo MA (MCG and AC contributed equally) Overcoming anoikis - pathways to anchorage-independent growth in cancer. J Cell Sci (2011) 124:3189-97
Cerezo A*, Guadamillas MC*, Goetz JG, Sanchez-Perales S, Klein E, Assoian RK, del Pozo MA (AC and MCG contributed equally) The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism. Mol Cell Biol (2009) 29:5046-59
Santibanez JF, Blanco FJ, Garrido-Martin EM, Sanz-Rodriguez F, del Pozo MA, Bernabeu C. Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae. Cardiovasc Res (2008) 77:791-9
Strippoli R, Benedicto I, Pérez Lozano ML, Cerezo A, López-Cabrera M, del Pozo MA. Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappaB/Snail1 pathway. Dis Model Mech (2008) 1:264-74
Grande-García A, Echarri A, de Rooij J, Alderson NB, Waterman-Storer CM, Valdivielso JM, del Pozo MA. Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. J Cell Biol (2007) 177:683-94