Selected publications

Del Campo L*, Sanchez-Lopez A*, Salaices M, von Kleeck RA, Exposito E, Gonzalez-Gomez C, Cusso L, Guzman-Martinez G, Ruiz-Cabello J, Desco M, Assoian RK, Briones AM, Andres V. (LDC and ASL contributed equally) Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite. Aging Cell (2019) Mar 18 [Epub ahead of print]
Hamczyk MR, Villa-Bellosta R, Quesada V, Gonzalo P, Vidak S, Nevado RM, Andrés-Manzano MJ, Misteli T, López-Otín C, Andrés V. Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells. EMBO Mol Med (2019) 11:e9736
Hamczyk MR, Del Campo L, Andres V. Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome. Annu Rev Physiol (2018) 80:27-48
Hamczyk MR, Villa-Bellosta R, Gonzalo P, Andres-Manzano MJ, Nogales P, Bentzon JF, Lopez-Otin C, Andres V. Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome. Circulation (2018) 138:266-82
Fuster JJ*, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu C-L, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AAB, Cooper MA, Andres V, Hirschi KK, Martin KA, Walsh K* (JJF and KW are co-corresponding authors). Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice. Science (2017) 355:842-7
Dorado B, Andres V. A-type lamins and cardiovascular disease in premature aging syndromes Curr Opin Cell Biol (2017) 46:17–25
Fernández-Alvira JM, Fuster V, Dorado B, Soberón N, Flores I, Gallardo M, Pocock S, Blasco MA, Andrés V. Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study. J Am Coll Cardiol (2016) 67:2467-76
Rivera-Torres J, Calvo CJ, Llach A, Guzman-Martinez G, Caballero R, Gonzalez-Gomez C, Jimenez-Borreguero LJ, Guadix JA, Osorio FG, Lopez-Otin C, Herraiz-Martinez A, Cabello N, Vallmitjana A, Benitez R, Gordon LB, Jalife J, Perez-Pomares JM, Tamargo J, Delpon E, Hove-Madsen L, Filgueiras-Rama D, Andres V. Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations. Proc Natl Acad Sci U S A (2016) 113:E7250–9
Chèvre R, González-Granado JM, Megens RT, Sreeramkumar V, Silvestre-Roig C, Molina-Sanchez P, Weber C, Soehnlein O, Hidalgo A*, Andrés V* (VA and AH contributed equally). High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice. Circ Res (2014) 114:770-9
González-Granado JM*, Silvestre-Roig C*, Rocha-Perugini V*, Trigueros-Motos L, Cibrián D, Morlino G, Blanco-Berrocal M, Osorio FG, Freije JM, López-Otín C, Sánchez-Madrid F*, Andrés V* (CSR and VRP contributed equally; JMGG, FSM and VA co-corresponding authors) Nuclear envelope lamin-a couples actin dynamics with immunological synapse architecture and T cell activation. Science Signaling (2014) 7:ra37
Villa-Bellosta R, Rivera J, Osorio FG, Acín-Pérez R, Enríquez JA, López-Otín C, Andrés V. Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that is Ameliorated upon Pyrophosphate Treatment. Circulation (2013) 127:2442-51
Trigueros-Motos L, González-Granado JM, Cheung C, Fernández P, Sánchez-Cabo F, Dopazo A, Sinha S, Andrés V. Embryological-Origin-Dependent Differences in Hox Expression in Adult Aorta: Role in Regional Phenotypic Variability and Regulation of NF-κB Activity. Arterioscler Thromb Vasc Biol (2013) 33:1248-56
González-Navarro H, Vinué A, Sanz MJ, Delgado M, Pozo MA, Serrano M, Burks DJ, Andrés V. Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging Aging Cell (2013) 12:102-11
Fuster JJ, González-Navarro H, Vinué A, Molina P, Andrés-Manzano MJ, Nakayama KI, Nakayama K, Díez-Juan A, Bernad A, Rodríguez C, Martínez-González J, Andrés V. Deficient p27 Phosphorylation at Serine 10 Increases Macrophage Foam Cell Formation and Aggravates Atherosclerosis Through a Proliferation-Independent Mechanism. Arterioscler Thromb Vasc Biol (2011) 31:2455-2463
Osorio FG, Navarro CL, Cadiñanos J, López-Mejía IC, Quirós PM, Bartoli C, Rivera J, Tazi J, Guzmán G, Varela I, Depetris D, de Carlos F, Cobo J, Andrés V, De Sandre-Giovannoli A, Freije JM, Lévy N, López-Otín C. Splicing-directed therapy in a new mouse model of human accelerated aging. Sci Transl Med (2011) 3:106ra107
González-Navarro H, Abu Nabah Y, Vinué A, Andrés-Manzano MJ, Collado M, Serrano M, Andrés V. p19(ARF) Deficiency Reduces Macrophage and Vascular Smooth Muscle Cell Apoptosis and Aggravates Atherosclerosis. J Am Coll Cardiol (2010) 55:2258-68
Andres V, Gonzalez JM. Role of A-type lamins in signaling, transcription, and chromatin organization J Cell Biol (2009) 187:945-57
González JM, Navarro-Puche A, Casar B, Crespo P, Andrés V. Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. J Cell Biol (2008) 183:653-66
Ivorra C, Kubicek M, González JM, Sanz-González SM, Alvarez-Barrientos A, O'Connor JE, Burke B, Andrés V. A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. Genes Dev (2006) 20:307-20
Fuster JJ, Andrés V. Telomere biology and cardiovascular disease. Circ Res (2006) 99:1167-80