Selected publications

Hamczyk MR, Del Campo L, Andres V. Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome. Annu Rev Physiol (2018) 80:27-48
Hamczyk MR, Villa-Bellosta R, Gonzalo P, Andres-Manzano MJ, Nogales P, Bentzon JF, Lopez-Otin C, Andres V. Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome. Circulation (2018) Mar 2 [IEpub ahead of print]
Molina-Sanchez P*, Del Campo L*, Esteban V, Rius C, Chevre R, Fuster JJ, Ferrer M, Redondo JM, Andres V. (PMS and LdC contributed equally) Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation. J Mol Cell Cardiol (2018) 116:5-15
Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu C-L, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AAB, Cooper MA, Andres V, Hirschi KK, Martin KA, Walsh K. Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice. Science (2017) 355:842-7
Dorado B, Andres V. A-type lamins and cardiovascular disease in premature aging syndromes Curr Opin Cell Biol (2017) 46:17–25
Fernández-Alvira JM, Fuster V, Dorado B, Soberón N, Flores I, Gallardo M, Pocock S, Blasco MA, Andrés V. Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study. J Am Coll Cardiol (2016) 67:2467-76
Rivera-Torres J, Calvo CJ, Llach A, Guzman-Martinez G, Caballero R, Gonzalez-Gomez C, Jimenez-Borreguero LJ, Guadix JA, Osorio FG, Lopez-Otin C, Herraiz-Martinez A, Cabello N, Vallmitjana A, Benitez R, Gordon LB, Jalife J, Perez-Pomares JM, Tamargo J, Delpon E, Hove-Madsen L, Filgueiras-Rama D, Andres V. Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations. Proc Natl Acad Sci U S A (2016) 113:E7250–9
Molina-Sanchez P, Chevre R, Rius C, Fuster JJ, Andres V Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK. J Mol Cell Cardiol (2015) 84:84-94
Chèvre R, González-Granado JM, Megens RT, Sreeramkumar V, Silvestre-Roig C, Molina-Sanchez P, Weber C, Soehnlein O, Hidalgo A*, Andrés V* (VA and AH contributed equally). High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice. Circ Res (2014) 114:770-9
González-Granado JM*, Silvestre-Roig C*, Rocha-Perugini V*, Trigueros-Motos L, Cibrián D, Morlino G, Blanco-Berrocal M, Osorio FG, Freije JM, López-Otín C, Sánchez-Madrid F*, Andrés V* (CSR and VRP contributed equally; JMGG, FSM and VA co-corresponding authors) Nuclear envelope lamin-a couples actin dynamics with immunological synapse architecture and T cell activation. Science Signaling (2014) 7:ra37
Villa-Bellosta R, Rivera J, Osorio FG, Acín-Pérez R, Enríquez JA, López-Otín C, Andrés V. Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that is Ameliorated upon Pyrophosphate Treatment. Circulation (2013) 127:2442-51
Trigueros-Motos L, González-Granado JM, Cheung C, Fernández P, Sánchez-Cabo F, Dopazo A, Sinha S, Andrés V. Embryological-Origin-Dependent Differences in Hox Expression in Adult Aorta: Role in Regional Phenotypic Variability and Regulation of NF-κB Activity. Arterioscler Thromb Vasc Biol (2013) 33:1248-56
González-Navarro H, Vinué A, Sanz MJ, Delgado M, Pozo MA, Serrano M, Burks DJ, Andrés V. Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging Aging Cell (2013) 12:102-11
Fuster JJ, González-Navarro H, Vinué A, Molina P, Andrés-Manzano MJ, Nakayama KI, Nakayama K, Díez-Juan A, Bernad A, Rodríguez C, Martínez-González J, Andrés V. Deficient p27 Phosphorylation at Serine 10 Increases Macrophage Foam Cell Formation and Aggravates Atherosclerosis Through a Proliferation-Independent Mechanism. Arterioscler Thromb Vasc Biol (2011) 31:2455-2463
Osorio FG, Navarro CL, Cadiñanos J, López-Mejía IC, Quirós PM, Bartoli C, Rivera J, Tazi J, Guzmán G, Varela I, Depetris D, de Carlos F, Cobo J, Andrés V, De Sandre-Giovannoli A, Freije JM, Lévy N, López-Otín C. Splicing-directed therapy in a new mouse model of human accelerated aging. Sci Transl Med (2011) 3:106ra107
González-Navarro H, Abu Nabah Y, Vinué A, Andrés-Manzano MJ, Collado M, Serrano M, Andrés V. p19(ARF) Deficiency Reduces Macrophage and Vascular Smooth Muscle Cell Apoptosis and Aggravates Atherosclerosis. J Am Coll Cardiol (2010) 55:2258-68
Andres V, Gonzalez JM. Role of A-type lamins in signaling, transcription, and chromatin organization J Cell Biol (2009) 187:945-57
González JM, Navarro-Puche A, Casar B, Crespo P, Andrés V. Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. J Cell Biol (2008) 183:653-66
Ivorra C, Kubicek M, González JM, Sanz-González SM, Alvarez-Barrientos A, O'Connor JE, Burke B, Andrés V. A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. Genes Dev (2006) 20:307-20
Fuster JJ, Andrés V. Telomere biology and cardiovascular disease. Circ Res (2006) 99:1167-80