Selected publications

Padron-Barthe L, Villalba-Orero M, Gomez-Salinero J, Acin-Perez R, Cogliati S, Lopez-Olaneta M, Ortiz-Sanchez P, Bonzon-Kulichenko E, Vazquez J, Garcia-Pavia P, Rosenthal N, Enriquez JA, Lara-Pezzi E. Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function. J Am Coll Cardiol (2018) 71:654-67
Link to the full text in Repisalud
Acin-Perez R, Lechuga-Vieco AV, Del Mar Munoz M, Nieto-Arellano R, Torroja C, Sanchez-Cabo F, Jimenez C, Gonzalez-Guerra A, Carrascoso I, Beninca C, Quiros PM, Lopez-Otin C, Castellano JM, Ruiz-Cabello J, Jimenez-Borreguero LJ, Enriquez JA. Ablation of the stress protease OMA1 protects against heart failure in mice. Sci Transl Med (2018) 10:4935
Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco AV, Sánchez-Cabo F, Torroja C, Acín-Pérez R, Calvo E, Aix E, González-Guerra A, Logan A, Bernad-Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez-Martos A, Fernández-Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA. Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature (2016) 525:561-65
Cogliati S*, Calvo E*, Loureiro M, Guaras AM, Nieto-Arellano R, Garcia-Poyatos C, Ezkurdia I, Mercader N, Vazquez J*, Enriquez JA* (SC and EC contributed equally; JV and JAE are co-corresponding authors) Mechanism of super-assembly of respiratory complexes III and IV. Nature (2016) 539:579-82
Garaude J*, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA*, Sancho D* (JG, JAE and DS are co-corresponding authors) Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defence Nat Immunol (2016) 17:1037-45
Enriquez JA. Supramolecular Organization of Respiratory Complexes. Annu Rev Physiol (2016) 78:533-61
Guaras A, Perales-Clemente E, Calvo E, Acin-Perez R, Loureiro-Lopez M, Pujol C, Martinez-Carrascoso I, Nunez E, Garcia-Marques F, Rodriguez-Hernandez MA, Cortes A, Diaz F, Perez-Martos A, Moraes CT, Fernandez-Silva P, Trifunovic A, Navas P, Vazquez J, Enriquez JA. The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency. Cell Rep (2016) 15:197-209
Link to the full text in Repisalud
Baixauli F, Acin-Perez R, Villarroya-Beltri C, Mazzeo C, Nunez-Andrade N, Gabande-Rodriguez E, Ledesma MD, Blazquez A, Martin MA, Falcon-Perez JM, Redondo JM, Enriquez JA, Mittelbrunn M. Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses Cell Metab (2015) 22:485-98
Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sánchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G and Enríquez JA ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use. Cell Metab (2014) 19:1020-33
Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, Cipolat S, Costa V, Casarin A, Gomes LC, Perales-Clemente E, Salviati L, Fernandez-Silva P, Enriquez JA*, Scorrano L* (JAE and LS co-corresponding authors) Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency Cell (2013) 155:160-71
Link to the full text in Repisalud
Lapuente-Brun E, Moreno-Loshuertos R, Acin-Perez R, Latorre-Pellicer A, Colas C, Balsa E, Perales-Clemente E, Quiros PM, Calvo E, Rodriguez-Hernandez MA, Navas P, Cruz R, Carracedo A, Lopez-Otin C, Perez-Martos A, Fernandez-Silva P, Fernandez-Vizarra E, Enriquez JA Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain Science (2013) 340:1567-70
Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landázuri MO, Enríquez JA. NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain Cell Metab (2012) 16:378-86
Moreno-Loshuertos R, Ferrín G, Acín-Pérez R, Gallardo ME, Viscomi C, Pérez-Martos A, Zeviani M, Fernández-Silva P, Enríquez JA. Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations. PLoS Genet (2011) 7:e1001379
Perales-Clemente E, Fernández-Silva P, Acín-Pérez R, Pérez-Martos A, Enríquez JA. Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task? Nucleic Acids Res (2011) 39:225-34
Perales-Clemente E, Fernández-Vizarra E, Acín-Pérez R, Movilla N, Bayona-Bafaluy MP, Moreno-Loshuertos R, Pérez-Martos A, Fernández-Silva P, Enríquez JA. Five Entry Points of the Mitochondrially Encoded Subunits in Mammalian Complex I Assembly. Mol Cell Biol (2010) 30:3038-47
Fernandez-Vizarra E, Ferrin G, Perez-Martos A, Fernandez-Silva P, Zeviani M, Enriquez JA. Isolation of mitochondria for biogenetical studies: An update. Mitochondrion (2010) 10:253-62
Acín-Pérez R, Fernández-Silva P, Peleato ML, Pérez-Martos A, Enriquez JA. Respiratory active mitochondrial supercomplexes. Mol Cell (2008) 32:529-39
Perales-Clemente E, Bayona-Bafaluy MP, Pérez-Martos A, Barrientos A, Fernández-Silva P, Enriquez JA. Restoration of electron transport without proton pumping in mammalian mitochondria. Proc Natl Acad Sci U S A (2008) 105:18735-9
Moreno-Loshuertos R, Acín-Pérez R, Fernández-Silva P, Movilla N, Pérez-Martos A, Rodriguez de Cordoba S, Gallardo ME, Enríquez JA. Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants. Nat Genet (2006) 38:1261-8
Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P, Moreno-Loshuertos R, Pérez-Martos A, Bruno C, Moraes CT, Enríquez JA. Respiratory complex III is required to maintain complex I in mammalian mitochondria. Mol Cell (2004) 13:805-15