Publicaciones seleccionadas

Paredes A, Justo-Méndez R, Jiménez-Blasco D, Núñez V, Calero I, Villalba-Orero M, Alegre-Martí A, Fischer T, Gradillas A, Sant'Anna VAR, Were F, Huang Z, Hernansanz-Agustín P, Contreras C, Martínez F, Camafeita E, Vázquez J, Ruiz-Cabello J, Area-Gómez E, Sánchez-Cabo F, Treuter E, Bolaños JP, Estébanez-Perpiñá E, Rupérez FJ, Barbas C, Enríquez JA, Ricote M. γ-Linolenic acid in maternal milk drives cardiac metabolic maturation. Nature (2023) 618:365-373
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Curtabbi A, Guarás A, Cabrera-Alarcón JL, Rivero M, Calvo E, Rosa-Moreno M, Vázquez J, Medina M, Enríquez JA. Regulation of respiratory complex I assembly by FMN cofactor targeting. Redox Biol (2023) 69:103001
Lechuga-Vieco AV, Latorre-Pellicer A, Calvo E, Torroja C, Pellico J, Acín-Pérez R, García-Gil ML, Santos A, Bagwan N, Bonzon-Kulichenko E, Magni R, Benito M, Justo-Méndez R, Simon AK, Sánchez-Cabo F, Vázquez J, Ruíz-Cabello J, Enríquez JA. Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty. Circulation (2022) 145:1084-1101
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Hong X, Isern J, Campanario S, Perdiguero E, Ramírez-Pardo I, Segalés J, Hernansanz-Agustín P, Curtabbi A, Deryagin O, Pollán A, González-Reyes JA, Villalba JM, Sandri M, Serrano AL, Enríquez JA, Muñoz-Cánoves P. Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. Cell Stem Cell (2022) 29:1298
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Cabrera-Alarcon JL, Martinez JG, Enríquez JA, Sánchez-Cabo F. Variant pathogenic prediction by locus variability: the importance of the current picture of evolution. Eur J Hum Genet (2022) 30:555-559
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Cogliati S, Cabrera-Alarcón JL, Enriquez JA Regulation and functional role of the electron transport chain supercomplexes. Biochem Soc Trans (2021) 49:2655-2668
Hernansanz-Agustín P, Enríquez JA Generation of Reactive Oxygen Species by Mitochondria Antioxidants (2021) 10:415
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Hernansanz-Agustín P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Piña T, Moreno L, Izquierdo-Álvarez A, Cabrera-García JD, Cortés A, Lechuga-Vieco AV, Jadiya P, Navarro E, Parada E, Palomino-Antolín A, Tello D, Acín-Pérez R, Rodríguez-Aguilera JC, Navas P, Cogolludo Á, López-Montero I, Martínez-Del-Pozo Á, Egea J, López MG, Elrod JW, Ruíz-Cabello J, Bogdanova A, Enríquez JA, Martínez-Ruiz A Na(+) controls hypoxic signalling by the mitochondrial respiratory chain Nature (2020) 586:287-291
Nicolas-Avila JA, Lechuga-Vieco AV, Esteban-Martinez L, Sanchez-Diaz M, Diaz-Garcia E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martinez-de-Mena R, Castejon-Vega B, Pun-Garcia A, Traves PG, Bonzon-Kulichenko E, Garcia-Marques F, Cusso L, N AG, Gonzalez-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzman G, Larrazabal J, Herrero-Galan E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Munoz-Canoves P, Ibanez B, Torres M, Ng LG, Priori SG, Bueno H, Vazquez J, Cordero MD, Bernal JA, Enriquez JA, Hidalgo A A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart Cell (2020) 183:94-109
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Garcia-Poyatos C, Cogliati S, Calvo E, Hernansanz-Agustin P, Lagarrigue S, Magni R, Botos M, Langa X, Amati F, Vazquez J, Mercader N, Enriquez JA Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish EMBO Rep (2020) 21:e50287
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Calvo E, Cogliati S, Hernansanz-Agustín P, Loureiro-López M, Guarás A, Casuso RA, García-Marqués F, Acín-Pérez R, Martí-Mateos Y, Silla-Castro J, Carro-Alvarellos M, Huertas JR, Vázquez J*, Enríquez JA* (JV and JAE are co-corresponding authors) Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Qpool Sci Adv (2020) 6:eaba7509
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Lechuga-Vieco AV, Latorre-Pellicer A, Johnston IG, Prota G, Gileadi U, Justo-Méndez R, Acín-Pérez R, Martínez-de-Mena R, Fernández-Toro JM, Jimenez-Blasco D, Mora A, Nicolás-Ávila JA, Santiago DJ, Priori SG, Bolaños JP, Sabio G, Criado LM, Ruíz-Cabello J, Cerundolo V, Jones NS, Enríquez JA Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics Sci Adv (2020) 6:eaba5345
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Acin-Perez R, Iborra S, Marti-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, Munoz MDM, Martinez de Mena R, Krishnan KC, Jimenez C, Bolanos JP, Laakso M, Lusis AJ, Shirihai OS, Sancho D, Enriquez JA Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity Nat Metab (2020) 2:974-988
Latorre-Pellicer A, Lechuga-Vieco AV, Johnston IG, Hamalainen RH, Pellico J, Justo-Mendez R, Fernandez-Toro JM, Claveria C, Guaras A, Sierra R, Llop J, Torres M, Criado LM, Suomalainen A, Jones NS, Ruiz-Cabello J, Enriquez JA Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy Cell Metab (2019) 30:1120-30
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Acin-Perez R, Lechuga-Vieco AV, Del Mar Munoz M, Nieto-Arellano R, Torroja C, Sanchez-Cabo F, Jimenez C, Gonzalez-Guerra A, Carrascoso I, Beninca C, Quiros PM, Lopez-Otin C, Castellano JM, Ruiz-Cabello J, Jimenez-Borreguero LJ, Enriquez JA. Ablation of the stress protease OMA1 protects against heart failure in mice. Sci Transl Med (2018) 10:4935
Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco AV, Sánchez-Cabo F, Torroja C, Acín-Pérez R, Calvo E, Aix E, González-Guerra A, Logan A, Bernad-Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez-Martos A, Fernández-Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA. Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature (2016) 525:561-65
Cogliati S*, Calvo E*, Loureiro M, Guaras AM, Nieto-Arellano R, Garcia-Poyatos C, Ezkurdia I, Mercader N, Vazquez J*, Enriquez JA* (SC and EC contributed equally; JV and JAE are co-corresponding authors) Mechanism of super-assembly of respiratory complexes III and IV. Nature (2016) 539:579-82
Enriquez JA. Supramolecular Organization of Respiratory Complexes. Annu Rev Physiol (2016) 78:533-61
Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sánchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G and Enríquez JA ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use. Cell Metab (2014) 19:1020-33
Lapuente-Brun E, Moreno-Loshuertos R, Acin-Perez R, Latorre-Pellicer A, Colas C, Balsa E, Perales-Clemente E, Quiros PM, Calvo E, Rodriguez-Hernandez MA, Navas P, Cruz R, Carracedo A, Lopez-Otin C, Perez-Martos A, Fernandez-Silva P, Fernandez-Vizarra E, Enriquez JA Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain Science (2013) 340:1567-70