Selected publications

    Romero-Becerra R, Mora A, Manieri E, Nikolic I, Santamans AM, Montalvo-Romeral V, Cruz FM, Rodríguez E, León M, Leiva-Vega L, Sanz L, Bondía V, Filgueiras-Rama D, Jiménez-Borreguero LJ, Jalife J, Gonzalez-Teran B, Sabio G. MKK6 deficiency promotes cardiac dysfunction through MKK3-p38gamma/delta-mTOR hyperactivation. eLife (2022) 11
    Link to the full text in Repisalud
    Macías Á, Díaz-Larrosa JJ, Blanco Y, Fanjul V, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, da Rocha AM, Ponce-Balbuena D, Allan A, Filgueiras-Rama D, Jalife J, Andrés V Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson-Gilford progeria syndrome Cardiovasc Res (2022) 118:503-516
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    Filgueiras-Rama D, Vasilijevic J, Jalife J, Noujaim SN, Alfonso JM, Nicolas-Avila JA, Gutierrez C, Zamarreno N, Hidalgo A, Bernabe A, Cop CP, Ponce-Balbuena D, Guerrero-Serna G, Calle D, Desco M, Ruiz-Cabello J, Nieto A, Falcon A Human Influenza A virus causes myocardial and cardiac-specific conduction system infection associated with early inflammation and premature death Cardiovasc Res (2021) 117:876-889
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    Quintanilla JG, Shpun S, Jalife J, Filgueiras-Rama D Novel approaches to mechanism-based atrial fibrillation ablation Cardiovasc Res (2021) 117:1662-1681
    Merino-Caviedes S, Gutierrez LK, Alfonso-Almazán JM, Sanz-Estébanez S, Cordero-Grande L, Quintanilla JG, Sánchez-González J, Marina-Breysse M, Galán-Arriola C, Enríquez-Vázquez D, Torres C, Pizarro G, Ibáñez B, Peinado R, Merino JL, Pérez-Villacastín J, Jalife J, López-Yunta M, Vázquez M, Aguado-Sierra J, González-Ferrer JJ, Pérez-Castellano N, Martín-Fernández M, Alberola-López C, Filgueiras-Rama D Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy Sci Rep (2021) 11:18722
    Marina-Breysse Manuel, García-Escolano Alba, Vila-García Joaquín, Reale-Nosei Gabriel, Alfonso-Almazán José M., Yan Ping, Quintanilla Jorge G., Loew Leslie M., Lee Peter, Filgueiras-Rama David A Complete and Low-Cost Cardiac Optical Mapping System in Translational Animal Models Front Physiol (2021) 12:696270
    Lillo-Castellano JM, Gonzalez-Ferrer JJ, Marina-Breysse M, Martinez-Ferrer JB, Perez-Alvarez L, Alzueta J, Martinez JG, Rodriguez A, Rodriguez-Perez JC, Anguera I, Vinolas X, Garcia-Alberola A, Quintanilla JG, Alfonso-Almazan JM, Garcia J, Borrego L, Canadas-Godoy V, Perez-Castellano N, Perez-Villacastin J, Jimenez-Diaz J, Jalife J, Filgueiras-Rama D Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices Europace (2020) 22:704-15
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    Quintanilla JG, Alfonso-Almazan JM, Perez-Castellano N, Pandit SV, Jalife J, Perez-Villacastin J, Filgueiras-Rama D Instantaneous Amplitude and Frequency Modulations Detect The Footprint of Rotational Activity and Reveal Stable Driver Regions as Targets for Persistent Atrial Fibrillation Ablation Circ Res (2019) 125:609-27
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    Lee P, Quintanilla JG, Alfonso-Almazan JM, Galan-Arriola C, Yan P, Sanchez-Gonzalez J, Perez-Castellano N, Perez-Villacastin J, Ibanez B, Loew LM, Filgueiras-Rama D. In-Vivo Ratiometric Optical Mapping Enables High-Resolution Cardiac Electrophysiology in Pig Models. Cardiovasc Res (2019) 115:1659-71
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    Lopez-Yunta M, Leon DG, Alfonso-Almazan JM, Marina-Breysse M, Quintanilla JG, Sanchez-Gonzalez J, Galan-Arriola C, Canadas-Godoy V, Enriquez-Vazquez D, Torres C, Ibanez B, Perez-Villacastin J, Perez-Castellano N, Jalife J, Vazquez M, Aguado-Sierra J, Filgueiras-Rama D. Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction. Europace (2019) 21:163-174
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    Leon DG, Lopez-Yunta M, Alfonso-Almazan JM, Marina-Breysse M, Quintanilla JG, Sanchez-Gonzalez J, Galan-Arriola C, Castro-Nunez F, Gonzalez-Ferrer JJ, Ibanez B, Perez-Villacastin J, Perez-Castellano N, Fuster V, Jalife J, Vazquez M, Aguado-Sierra J, Filgueiras-Rama D. Three-dimensional cardiac fibre disorganization as a novel parameter for ventricular arrhythmia stratification after myocardial infarction. Europace (2019) 21:822-32
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    Alfonso-Almazan JM, Quintanilla JG, Garcia-Torrent MJ, Laguna-Castro S, Rodriguez-Bobada C, Gonzalez P, Gonzalez-Ferrer JJ, Salinas P, Canadas-Godoy V, Moreno J, Borrego-Bernabe L, Perez-Castellano N, Jalife J, Perez-Villacastin J, Filgueiras-Rama D Lesion Index Titration Using Contact-Force Technology Enables Safe and Effective Radiofrequency Lesion Creation at the Root of the Aorta and Pulmonary Artery Circ Arrhythm Electrophysiol (2019) 12:e007080
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    Ramirez RJ, Takemoto Y, Martins RP, Filgueiras-Rama D, Ennis SR, Mironov S, Bhushal S, Deo M, Rajamani S, Berenfeld O, Belardinelli L, Jalife J, Pandit SV Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation Circ Arrhythm Electrophysiol (2019) 12:e005557
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    Calvo D, Filgueiras-Rama D, Jalife J. Mechanisms and Drug Development in Atrial Fibrillation. Pharmacol Rev (2018) 70:505-25
    Caballero R, Utrilla RG, Amoros I, Matamoros M, Perez-Hernandez M, Tinaquero D, Alfayate S, Nieto-Marin P, Guerrero-Serna G, Liu QH, Ramos-Mondragon R, Ponce-Balbuena D, Herron T, Campbell KF, Filgueiras-Rama D, Peinado R, Lopez-Sendon JL, Jalife J, Delpon E, Tamargo J. Tbx20 controls the expression of the KCNH2 gene and of hERG channels. Proc Natl Acad Sci U S A (2017) 114:E416-25
    Rivera-Torres J, Calvo CJ, Llach A, Guzman-Martinez G, Caballero R, Gonzalez-Gomez C, Jimenez-Borreguero LJ, Guadix JA, Osorio FG, Lopez-Otin C, Herraiz-Martinez A, Cabello N, Vallmitjana A, Benitez R, Gordon LB, Jalife J, Perez-Pomares JM, Tamargo J, Delpon E, Hove-Madsen L, Filgueiras-Rama D, Andres V. Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations. Proc Natl Acad Sci U S A (2016) 113:E7250–9
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    Lillo-Castellano JM, Marina-Breysse M, Gomez-Gallanti A, Martinez-Ferrer JB, Alzueta J, Perez-Alvarez L, Alberola A, Fernandez-Lozano I, Rodriguez A, Porro R, Anguera I, Fontenla A, Gonzalez-Ferrer JJ, Canadas-Godoy V, Perez-Castellano N, Garofalo D, Salvador-Montanes O, Calvo CJ, Quintanilla JG, Peinado R, Mora-Jimenez I, Perez-Villacastin J, Rojo-Alvarez JL, Filgueiras-Rama D. Safety threshold of R-wave amplitudes in patients with implantable cardioverter defibrillator. Heart (2016) 102:1662-70
    Filgueiras-Rama D, Calvo CJ, Salvador-Montanes O, Cadenas R, Ruiz-Cantador J, Armada E, Rey JR, Merino JL, Peinado R, Perez-Castellano N, Perez-Villacastin J, Quintanilla JG, Jimenez S, Castells F, Chorro FJ, Lopez-Sendon JL, Berenfeld O, Jalife J, de Sa EL, Millet J Spectral analysis-based risk score enables early prediction of mortality and cerebral performance in patients undergoing therapeutic hypothermia for ventricular fibrillation and comatose status Int J Cardiol (2015) 186:250-8
    Martins RP, Kaur K, Hwang E, Ramirez RJ, Willis BC, Filgueiras-Rama D, Ennis SR, Takemoto Y, Ponce-Balbuena D, Zarzoso M, O'Connell RP, Musa H, Guerrero-Serna G, Avula UM, Swartz MF, Bhushal S, Deo M, Pandit SV, Berenfeld O, Jalife J. Dominant Frequency Increase Rate Predicts Transition from Paroxysmal to Long-Term Persistent Atrial Fibrillation. Circulation (2014) 129:1472-82

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