Selected publications

    Romero-Becerra R, Cruz FM, Mora A, López JA, Ponce-Balbuena D, Allan A, Ramos-Mondragón R, González-Terán B, León M, Rodríguez ME, Leiva-Vega L, Guerrero-Serna G, Jimenez-Vazquez EN, Filgueiras-Rama D, Vázquez J, Jalife J, Sabio G. p38 delta activation alters cardiac electrical activity and predisposes to ventricular arrhythmia Nature Cardiovascular Research (2023) Nov 27 [Epub ahead of print]
    Link to the full text in Repisalud
    Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Pérez PS, Robles JMR, Bermúdez-Jiménez FJ, Díaz-Agustín A, de Benito FM, Santiago SA, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome. bioRxiv (2023) Jun 8 [Epub ahead of print]
    Link to the full text in Repisalud
    Jimenez-Vazquez EN, Arad M, Macías Á, Vera-Pedrosa ML, Cruz FM, Gutierrez LK, Cuttita AJ, Monteiro da Rocha A, Herron TJ, Ponce-Balbuena D, Guerrero-Serna G, Binah O, Michele DE, Jalife J. SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients eLife (2022) 11
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    Macías Á, Díaz-Larrosa JJ, Blanco Y, Fanjul V, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, da Rocha AM, Ponce-Balbuena D, Allan A, Filgueiras-Rama D, Jalife J, Andrés V Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson-Gilford progeria syndrome Cardiovasc Res (2022) 118:503-516
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    Manuel AIM, Gutiérrez LK, Pedrosa MLV, Uréndez FMC, Jiménez FJB, Carrascoso IM, Pérez PS, Macías Á, Jalife J. Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil Syndrome Cardiovasc Res (2022) :1-14
    Link to the full text in Repisalud
    Calvo D, Salinas L, Martínez-Camblor P, García-Iglesias D, Alzueta J, Rodríguez A, Romero R, Viñolas X, Fernández-Lozano I, Anguera I, Villacastín J, Bodegas A, Fontenla A, Jalife J, Berenfeld O Distinct spectral dynamics of implanted cardiac defibrillator signals in spontaneous termination of polymorphic ventricular tachycardia and fibrillation in patients with electrical and structural diseases Europace (2022) 24:1788-1799
    Link to the full text in Repisalud
    Macías Á, González-Guerra A, Moreno-Manuel AI, Cruz FM, Gutiérrez LK, García-Quintáns N, Roche-Molina M, Bermúdez-Jiménez F, Andrés V, Vera-Pedrosa ML, Martínez-Carrascoso I, Bernal JA, Jalife J. Kir2.1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen–Tawil syndrome type 1 Nature Cardiovascular Research (2022) 1:900–917
    Link to the full text in Repisalud
    Filgueiras-Rama D, Vasilijevic J, Jalife J, Noujaim SN, Alfonso JM, Nicolas-Avila JA, Gutierrez C, Zamarreno N, Hidalgo A, Bernabe A, Cop CP, Ponce-Balbuena D, Guerrero-Serna G, Calle D, Desco M, Ruiz-Cabello J, Nieto A, Falcon A Human Influenza A virus causes myocardial and cardiac-specific conduction system infection associated with early inflammation and premature death Cardiovasc Res (2021) 117:876-889
    Link to the full text in Repisalud
    Quintanilla JG, Shpun S, Jalife J, Filgueiras-Rama D Novel approaches to mechanism-based atrial fibrillation ablation Cardiovasc Res (2021) 117:1662-1681
    Alvarez-Franco A, Rouco R, Ramirez RJ, Guerrero-Serna G, Tiana M, Cogliati S, Kaur K, Saeed M, Magni R, Enriquez JA, Sanchez-Cabo F, Jalife J, Manzanares M Transcriptome and proteome mapping in the sheep atria reveal molecular features of atrial fibrillation progression Cardiovasc Res (2020) Nov 2 [Epub ahead of print]
    Lillo-Castellano JM, Gonzalez-Ferrer JJ, Marina-Breysse M, Martinez-Ferrer JB, Perez-Alvarez L, Alzueta J, Martinez JG, Rodriguez A, Rodriguez-Perez JC, Anguera I, Vinolas X, Garcia-Alberola A, Quintanilla JG, Alfonso-Almazan JM, Garcia J, Borrego L, Canadas-Godoy V, Perez-Castellano N, Perez-Villacastin J, Jimenez-Diaz J, Jalife J, Filgueiras-Rama D Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices Europace (2020) 22:704-15
    Link to the full text in Repisalud
    Park SS, Ponce-Balbuena D, Kuick R, Guerrero-Serna G, Yoon J, Mellacheruvu D, Conlon KP, Basrur V, Nesvizhskii AI, Jalife J, Rual JF Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents Mol Cell Proteomics (2020) 19:1436-1449
    Jalife J. The tornadoes of sudden cardiac arrest. Nature (2018) 555:597-98
    Calvo D, Filgueiras-Rama D, Jalife J. Mechanisms and Drug Development in Atrial Fibrillation. Pharmacol Rev (2018) 70:505-25
    Ponce-Balbuena D, Guerrero-Serna G, Valdivia CR, Caballero R, Diez-Guerra FJ, Jimenez-Vazquez EN, Ramirez RJ, Monteiro da Rocha A, Herron TJ, Campbell KF, Willis BC, Alvarado FJ, Zarzoso M, Kaur K, Perez-Hernandez M, Matamoros M, Valdivia HH, Delpon E, Jalife J. Cardiac Kir2.1 and NaV1.5 Channels Traffic Together to the Sarcolemma to Control Excitability. Circ Res (2018) 122:1501-16
    Willis BC, Pandit S, Ponce-Balbuena D, Zarzoso M, Guerrero-Serna G, Limbu B, Deo M, Cammors E, Ramirez RJ, Mironov S, Herron TJ, Valdivia HH, Jalife J. Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress than Ventricular Myocytes from Mice with Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation (2016) 133:2348-59
    Link to the full text in Repisalud
    Martins RP, Kaur K, Hwang E, Ramirez RJ, Willis BC, Filgueiras-Rama D, Ennis SR, Takemoto Y, Ponce-Balbuena D, Zarzoso M, O'Connell RP, Musa H, Guerrero-Serna G, Avula UM, Swartz MF, Bhushal S, Deo M, Pandit SV, Berenfeld O, Jalife J. Dominant Frequency Increase Rate Predicts Transition from Paroxysmal to Long-Term Persistent Atrial Fibrillation. Circulation (2014) 129:1472-82
    Pandit SV, Jalife J. Rotors and the dynamics of cardiac fibrillation. Circ Res (2013) 112:849-62
    Herron TJ, Lee P, Jalife J. Optical imaging of voltage and calcium in cardiac cells & tissues. Circ Res (2012) 110:609-23
    Milstein ML, Musa H, Balbuena DP, Anumonwo JM, Auerbach DS, Furspan PB, Hou L, Hu B, Schumacher SM, Vaidyanathan R, Martens JR, Jalife J. Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia. Proc Natl Acad Sci U S A (2012) 109:2134-43

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