Selected publications

Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature (2018) 557:439-45
MacGrogan D, Munch J, de la Pompa JL. Notch and interacting signalling pathways in cardiac development, disease, and regeneration. Nat Rev Cardiol (2018) 15:685-704
Munch J, Grivas D, Gonzalez-Rajal A, Torregrosa-Carrion R, de la Pompa JL. Notch signalling restricts inflammation and serpine1 in the dynamic endocardium of the regenerating zebrafish heart. Development (2017) 144:1425-40
D'Amato G, Luxan G, Del Monte-Nieto G, Martinez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jimenez-Borreguero LJ, de la Pompa JL. Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol (2016) 18:7-20
de Luxan G, D'Amato G, MacGrogan D, de la Pompa JL. Endocardial Notch Signaling in Cardiac Development and Disease. Circ Res (2016) 118:e1-18
MacGrogan D, D'Amato G, Travisano S, Martinez-Poveda B, de Luxan G, Del Monte-Nieto G, Papoutsi T, Sbroggio M, Bou V, Gomez-Del Arco P, Gomez MJ, Zhou B, Redondo JM, Jimenez-Borreguero LJ, de la Pompa JL. Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis. Circ Res (2016) 118:1480-97
Nus M*, Martinez-Poveda B*, MacGrogan D*, Chevre R, D'Amato G, Sbroggio M, Rodriguez C, Martinez-Gonzalez J, Andres V, Hidalgo A, de la Pompa JL. (MN, BMP and DM contributed equally) Endothelial Jag1-RBPJ signalling promotes inflammatory leukocyte recruitment and atherosclerosis. Cardiovasc Res (2016) 112:568-80
D'Amato G, Luxan G, de la Pompa JL. Notch signalling in ventricular chamber development & cardiomyopathy. FEBS J (2016) 283:4223-37
Cortegano I*, Melgar-Rojas P*, Luna-Zurita L, Siguero-Alvarez M, Marcos MA, Gaspar ML and de la Pompa JL (IC and PMR contributed equally) Notch1 regulates progenitor cell proliferation and differentiation during mouse yolk sac hematopoiesis. Cell Death Differ (2014) 21:1081-94
MacGrogan D, Luxan G, Driessen-Mol A, Bouten C, Baaijens F, de la Pompa JL How to Make a Heart Valve: From Embryonic Development to Bioengineering of Living Valve Substitutes Cold Spring Harb Perspect Med (2014) 4:a013912
Luxán G, Casanova JC*, Martínez-Poveda B*, Prados B, D'Amato G, Macgrogan D, Gonzalez-Rajal A, Dobarro D, Torroja C, Martinez F, Izquierdo-García JL, Fernández-Friera L, Sabater-Molina M, Kong YY, Pizarro G, Ibañez B, Medrano C, García-Pavía P, Gimeno JR, Monserrat L, Jiménez-Borreguero LJ, de la Pompa JL (JCC and BMP contributed equally) Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med (2013) 19:193-201
Münch J, González-Rajal A, de la Pompa JL. Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration. Development (2013) 140:1402-11
Bolos V, Mira E, Martinez Poveda B, Luxan G, Canamero M, Martinez-A C, Manes S, de la Pompa JL. Notch activation stimulates migration of breast cancer cells and promotes tumor growth Breast Cancer Res (2013) 15:R54
Link to the full text in Repisalud
de la Pompa JL, Eipstein JA Coordinating Tissue Interactions: Notch Signaling in Cardiac Development and Disease Dev Cell (2012) 22:244-54
Del Monte G, Casanova JC, Guadix JA, Macgrogan D, Burch JB, Pérez-Pomares JM, de la Pompa JL. Differential Notch Signaling in the Epicardium Is Required for Cardiac Inflow Development and Coronary Vessel Morphogenesis. Circ Res (2011) 108:824-36
Pérez-Pomares JM, de la Pompa JL Signaling during epicardium and coronary vessel development. Circ Res (2011) 109:1429-42
Nus M, Macgrogan D, Martínez-Poveda B, Benito Y, Casanova JC, Fernández-Avilés F, Bermejo J, de la Pompa JL. Diet-Induced Aortic Valve Disease in Mice Haploinsufficient for the Notch Pathway Effector RBPJK/CSL. Arterioscler Thromb Vasc Biol (2011) 31:1580-8
Luna-Zurita L, Prados B, Grego-Bessa J, Luxan G, del Monte G, Benguria A, Adams RH, Perez-Pomares JM, de la Pompa JL. Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation J Clin Invest (2010) 120:3493-507
Macgrogan D, Nus M, Pompa JL. Notch signaling in cardiac development and disease. Curr Top Dev Biol (2010) 92:333-65