Publicaciones seleccionadas

Gomez-Escudero J, Moreno V, Martin-Alonso M, de Riquer MVH, Feinberg T, Colmenar A, Calvo E, Camafeita E, Martinez F, Oudhoff MJ, Weiss SJ, Arroyo AG. E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine. J Cell Sci (2017) 130:4013-27
Blanco MJ, Rodriguez-Martin I, Learte AIR, Clemente C, Montalvo MG, Seiki M, Arroyo AG, Sanchez-Camacho C. Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo. PLoS One (2017) 12:e0184767
Link to the full text in Repisalud
Barreiro O, Cibrian D, Clemente C, Alvarez D, Moreno V, Valiente I, Bernad A, Vestweber D, Arroyo AG, Martin P, Andrian UV, Sanchez Madrid F. Pivotal role for skin trans-endothelial radio-resistant anti-inflammatory macrophages in tissue repair. eLife (2016) 5:e15251
Link to the full text in Repisalud
de Lucas AG, Schuhmacher AJ, Oteo M, Romero E, Camara JA, de Martino A, Arroyo AG, Morcillo MA, Squatrito M, Martinez-Torrecuadrada JL, Mulero F. Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas. PLoS One (2016) 11:e158634
Link to the full text in Repisalud
Martin-Alonso M, Garcia-Redondo AB, Guo D, Camafeita E, Martinez F, Alfranca A, Mendez-Barbero N, Pollan A, Sanchez-Camacho C, Denhardt DT, Seiki M, Vazquez J, Salaices M, Redondo JM, Milewicz DM, Arroyo AG Deficiency of MMP17/MT4-MMP Proteolytic Activity Predisposes to Aortic Aneurysm in Mice Circ Res (2015) 117:e13-26
Udi Y, Grossman M, Solomonov I, Dym O, Rozenberg H, Moreno V, Cuniasse P, Dive V, Arroyo AG, Sagi I Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody Structure (2015) 23:104-15
Oller J*, Alfranca A*, Mendez-Barbero N, Villahoz S, Lozano-Vidal N, Martin-Alonso M, Arroyo AG, Escolano A, Armesilla AL, Campanero MR, Redondo JM (JO and AA contributed equally) C/EBPbeta and NFAT differentially regulate Adamts-1 induction by stimuli associated with vascular remodeling. Mol Cell Biol (2015) 35:3409-22
Moreno V, Gonzalo P, Gomez-Escudero J, Pollan A, Acin-Perez R, Breckenridge M, Yanez-Mo M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enriquez JA, Dejana E, Sanchez-Madrid F, Arroyo AG. An EMMPRIN/gamma-catenin/Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. J Cell Sci (2014) 127:3768-81
Koziol A, Gonzalo P, Mota A, Pollán A, Lorenzo C, Colomé N, Montaner D, Dopazo J, Arribas J, Canals F, Arroyo AG. The protease MT1-MMP drives a combinatorial proteolytic program in activated endothelial cells. FASEB J (2012) 26:4418-94
Koziol A*, Martín-Alonso M*, Clemente C, Gonzalo P, Arroyo AG (AK and MMA contributed equally) Site-specific cellular functions of MT1-MMP. Eur J Cell Biol (2012) 91:889-95
Gonzalo P, Guadamillas MC, Hernandez-Riquer MV, Pollan A, Grande-Garcia A, Bartolome RA, Vasanji A, Ambrogio C, Chiarle R, Teixido J, Risteli J, Apte SS, del Pozo MA, Garcia-Arroyo A. MT1-MMP Is Required for Myeloid Cell Fusion via Regulation of Rac1 Signaling Dev Cell (2010) 18:77-89
Núñez V*, Alameda D*, Rico D, Mota R, Gonzalo P, Cedenilla M, Fischer T, Boscá L, Glass CK, Arroyo AG, Ricote M (VN and DA contributed equally) Retinoid X receptor {alpha} controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A (2010) 107:10626-31
Arroyo AG, Iruela-Arispe ML Extracellular Matrix, Inflammation, and the Angiogenic Response Cardiovasc Res (2010) 86:226-35
Gonzalo P, Moreno V, Gálvez BG, Arroyo AG. MT1-MMP and integrins: Hand-to-hand in cell communication. Biofactors (2010) 36:248-54
Alfranca A, López-Oliva JM, Genís L, López-Maderuelo D, Mirones I, Salvado D, Quesada AJ, Arroyo AG, Redondo JM. PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway. Blood (2008) 112:1120-8
Yañez-Mó M, Barreiro O, Gonzalo P, Batista A, Megías D, Genís L, Sachs N, Sala-Valdés M, Alonso MA, Montoya MC, Sonnenberg A, Arroyo AG, Sánchez-Madrid F. MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells. Blood (2008) 112:3217-26
Genís L, Gonzalo P, Tutor AS, Gálvez BG, Martínez-Ruiz A, Zaragoza C, Lamas S, Tryggvason K, Apte SS, Arroyo AG. Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells. Blood (2007) 110:2916-23
Bravo-Cordero JJ, Marrero-Diaz R, Megías D, Genís L, García-Grande A, García MA, Arroyo AG, Montoya MC. MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J (2007) 26:1499-510
Arroyo AG, Genís L, Gonzalo P, Matías-Román S, Pollán A, Gálvez BG. Matrix metalloproteinases: new routes to the use of MT1-MMP as a therapeutic target in angiogenesis-related disease. Curr Pharm Des (2007) 13:1787-802