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Fernández-Gallego N, Anega B, Luengo-Arias S, Bizkarguenaga M, Gil-Redondo R, Embade N, Navarrete-Arias L, Ramírez-Huesca M, Álvarez-Corrales E, Dosil SG, Castillo-González R, Rojas-Gomez A, Espeleta I, Martínez-Martínez S, Alfranca A, G de Yebenes V, Martín-Cófreces NB, Aragonés J, Martin P, Millet O, Sánchez-Madrid F, Cibrian D. Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response. EMBO Mol Med (2025) May 5 [Epub ahead of print]
Martinez-Val A, Van der Hoeven L, Bekker-Jensen DB, Jørgensen MM, Nors J, Franciosa G, Andersen CL, Bramsen JB, Olsen JV. Proteomics of colorectal tumors identifies the role of CAVIN1 in tumor relapse. MOL SYST BIOL (2025) 21:776-806
Link to the full text in Repisalud
Sendra M, McDole K, de Dios Hourcade J, Temiño S, Raiola M, Guignard L, Keller PJ, Domínguez JN, Torres M. Myocardium and endocardium of the early mammalian heart tube arise from independent multipotent lineages specified at the primitive streak. Dev Cell (2025) S1534-5807:00292-8
Sarno F, Tenorio J, Perea S, Medina L, Pazo-Cid R, Juez I, Garcia-Carbonero R, Feliu J, Guillen-Ponce C, Lopez-Casas PP, Guerra C, Duran Y, López-Acosta JF, Alonso C, Esquivel E, Dopazo A, Akshinthala D, Muthuswamy SK, Lapunzina P, Bockorny B, Hidalgo M. A Phase III Randomized Trial of Integrated Genomics and Avatar Models for Personalized Treatment of Pancreatic Cancer: The AVATAR Trial. CLIN CANCER RES (2025) 31:278-287
Garcia-Pavia P, Bilen O, Burroughs M, Costabel JP, de Barros Correia E, Dybro AM, Elliott P, Lakdawala NK, Mann A, Nair A, Nassif ME, Poulsen SH, Reant P, Schulze PC, Wang A, Berhane I, Heitner SB, Jacoby DL, Kupfer S, Malik FI, Meng L, Sohn R, Wohltman A, Fifer MA; MAPLE-HCM Study Investigators. Aficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM Rationale, Study Design, and Baseline Characteristics. JACC Heart Fail (2025) 13:346-357
Link to the full text in Repisalud
Desai MY, Nissen SE, Abraham T, Olivotto I, Garcia-Pavia P, Lopes RD, Verheyen N, Wever-Pinzon O, Wolski K, Jaber W, Mitchell L, Davey D, Myers J, Rano T, Bhatia V, Zhong Y, Carter-Bonanza S, Florea V, Aronson R, Owens AT; ODYSSEY-HCM Investigators. Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Design, Rationale, and Baseline Characteristics of ODYSSEY-HCM. JACC Heart Fail (2025) 13:358-370
Link to the full text in Repisalud
Saberi S, Abraham TP, Choudhury L, Barriales-Villa R, Elliott PM, Nassif ME, Oreziak A, Owens AT, Tower-Rader A, Rader F, Garcia-Pavia P, Olivotto I, Coats CJ, Fifer MA, Sherrid MV, Solomon SD, Watkins H, Heitner SB, Jacoby DL, Kupfer S, Malik FI, Melloni C, Meng L, Wei J, Maron MS, Masri A; FOREST-HCM Steering Committee and Investigators. Aficamten Treatment for Symptomatic Obstructive Hypertrophic Cardiomyopathy: 48-Week Results From FOREST-HCM. JACC Heart Fail (2025) 13:102496
Larrañaga-Moreira JM, Ochoa JP, Peteiro-Debén R, Martín-Álvarez E, Ripoll-Vera T, Álvarez-Rubio J, Peña-Peña ML, Llamas-Gómez H, Fernández A, Gallego-Delgado M, Rodríguez-Serrano AI, Díez-López C, Elliott PM, Palomino-Doza J, Lorca R, Limeres J, Azevedo O, Zorio E, Martín-Dorado E, Méndez-Fernández I, Franco-Gutiérrez R, de Frutos F, Escudero A, Ruiz-Guerrero L, Rodríguez-Vilela A, Mazzanti A, McKenna WJ, Barriales-Villa R; TNN Investigators. The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy. JACC Heart Fail (2025) 102419
Masri A, Maron MS, Abraham TP, Nassif ME, Barriales-Villa R, Bilen O, Coats CJ, Elliott P, Garcia-Pavia P, Massera D, Olivotto I, Oreziak A, Owens AT, Saberi S, Solomon SD, Tower-Rader A, Heitner SB, Jacoby DL, Melloni C, Wei J, Sherrid MV; REDWOOD-HCM, SEQUOIA-HCM, and FOREST-HCM Investigators. Concomitant Aficamten and Disopyramide in Symptomatic Obstructive Hypertrophic Cardiomyopathy. JACC Heart Fail (2025) 102441
Perotto M, Paldino A, Mazzarotto F, Barbati G, Stroeks SLVM, Verdonschot JAJ, Akhtar M, Elliott P, Ochoa JP, Garcia-Pavia P, de Frutos F, Sepp R, Hategan L, Prasad S, Yazdani M, Morris-Rosendahl D, Palinkas ED, Girolami F, Olivotto I, Parikh VN, Fatkin D, Lakdawala N, McKenna WJ, Stolfo D, Gigli M, Brun F, Collesi C, Giacca M, Zacchigna S, Severini GM, Lenarduzzi S, Spedicati B, Santin A, Girotto G, Gasparini P, Taylor MRG, Mestroni L, Merlo M, Sinagra G, Dal Ferro M. Genetic and Phenotypic Characterization of Nexilin (NEXN)-Related Cardiomyopathy: Results From a Multicentric Study. JACC Heart Fail (2025) 13:102529

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