Publicaciones seleccionadas

Menchero S, Sainz de Aja J, Manzanares M. Our First Choice: Cellular and Genetic Underpinnings of Trophectoderm Identity and Differentiation in the Mammalian Embryo. Curr Top Dev Biol (2018) 128:59-80
Tapial J, Ha KCH, Sterne-Weiler T, Gohr A, Braunschweig U, Hermoso-Pulido A, Quesnel-Vallieres M, Permanyer J, Sodaei R, Marquez Y, Cozzuto L, Wang X, Gomez-Velazquez M, Rayon T, Manzanares M, Ponomarenko J, Blencowe B, Irimia M. An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms. Genome Res (2017) 27:1759-68
Gomez-Velazquez M, Badia-Careaga C, Lechuga-Vieco AV, Nieto-Arellano R, Tena JJ, Rollan I, Alvarez A, Torroja C, Caceres EF, Roy A, Galjart N, Delgado-Olguin P, Sanchez-Cabo F, Enriquez JA, Gomez-Skarmeta JL, Manzanares M. CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart. PLoS Genet (2017) 13:e1006985
Menchero S, Rayon T, Andreu MJ, Manzanares M. Signaling pathways in mammalian preimplantation development: Linking cellular phenotypes to lineage decisions. Dev Dyn (2017) 246:245-61
Bogdanovic O, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra GJ, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen M, Gomez-Skarmeta JL, Lister R. Active DNA demethylation at enhancers during the vertebrate phylotypic period. Nat Genet (2016) 48:417-26
Rayon T, Menchero S, Rollan I, Ors I, Helness A, Crespo M, Nieto A, Azuara V, Rossant J, Manzanares M. Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells. Sci Rep (2016) 6:27139
Aguirre LA, Alonso ME, Badia-Careaga C, Rollan I, Arias C, Fernandez-Minan A, Lopez-Jimenez E, Aranega A, Gomez-Skarmeta JL, Franco D, Manzanares M. Long-range regulatory interactions at the 4q25 Atrial Fibrillation risk locus involve PITX2c and ENPEP. BMC Biol (2015) 13:26
Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gomez-Marin C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nobrega MA Obesity-associated variants within FTO form long-range functional connections with IRX3 Nature (2014) 507:371-5
Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J, Manzanares M. Notch and hippo converge on cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev Cell (2014) 30:410-22
Pernaute B, Spruce T, Smith KM, Sanchez-Nieto JM, Manzanares M, Cobb B, Rodriguez TA MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM Genes Dev (2014) 28:7073-8
van Weerd JH, Badi I, van den Boogaard M, Stefanovic S, van de Werken HJ, Gomez-Velazquez M, Badia-Careaga C, Manzanares M, de Laat W, Barnett P, Christoffels VM A Large Permissive Regulatory Domain Exclusively Controls Tbx3 Expression in the Cardiac Conduction System Circ Res (2014) 115:432-41
Piazzolla D, Palla AR, Pantoja C, Canamero M, de Castro IP, Ortega S, Gomez-Lopez G, Dominguez O, Megias D, Roncador G, Luque-Garcia JL, Fernandez-Tresguerres B, Fernandez AF, Fraga MF, Rodriguez-Justo M, Manzanares M, Sanchez-Carbayo M, Garcia-Pedrero JM, Rodrigo JP, Malumbres M, Serrano M. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat Commun (2014) 5:4226
Manzanares M. Functional genomics of cardiovascular development and disease Brief Funct Genomics (2014) 13:1-2
Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayon T, Ors I, Graña O, Megías D, Domínguez O, Martínez D, Manzanares M, Ortega S, Serrano M. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature (2013) 502:340-5
Manzanares M, Rodriguez TA. Development: hippo signalling turns the embryo inside out. Curr Biol (2013) 23:r559-61
Lara-Pezzi E, Dopazo A, Manzanares M. Understanding cardiovascular disease: a journey through the genome (and what we found there). Dis Model Mech (2012) 5:434-43
Martin D, Pantoja C, Miñán AF, Valdes-Quezada C, Moltó E, Matesanz F, Bogdanović O, de la Calle-Mustienes E, Domínguez O, Taher L, Furlan-Magaril M, Alcina A, Cañón S, Fedetz M, Blasco MA, Pereira PS, Ovcharenko I, Recillas-Targa F, Montoliu L, Manzanares M, Guigó R, Serrano M, Casares F, Gómez-Skarmeta JL. Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes Nat Struct Mol Biol (2011) 18:708-14
Tena JJ, Alonso ME, de la Calle-Mustienes E, Splinter E, de Laat W, Manzanares M, Gómez-Skarmeta JL. An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation. Nat Commun (2011) 2:310
Spruce T*, Pernaute B*, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M*, Rodriguez TA* (TS and BP contributed equally. MM and TAR co-corresponding authors) An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Dev Cell (2010) 19:207-19
Fernandez-Tresguerres B*, Cañon S*, Rayon T, Pernaute B, Crespo M, Torroja C, Manzanares M (BFT and SC contributed equally) Evolution of the mammalian embryonic pluripotency gene regulatory network Proc Natl Acad Sci U S A (2010) 107:19955-60