Publicaciones seleccionadas

Martinez-Sanchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buque X, Aurrekoetxea I, Delgado TC, Vazquez-Martinez R, Gonzalez-Garcia I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martinez de Morentin PB, Lopez-Gonzalez T, Linares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gomez G, Davis RJ, Casals N, Oresic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagon MM, Dieguez C, Martinez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, Lopez M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab (2017) 26:212-29
Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Ferno J, Gonzalez-Teran B, Matesanz N, Hernandez-Cosido L, Marcos M, Tovar S, Vidal A, Sanchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, Lopez M, Aspichueta P, Martinez-Chantar ML, Nogueiras R. Hepatic p63 regulates steatosis via IKKbeta/ER stress. Nat Commun (2017) 8:15111
Matesanz N, Bernardo E, Acin-Perez R, Manieri E, Perez-Sieira S, Hernandez-Cosido L, Montalvo-Romeral V, Mora A, Rodriguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Alvarez CV, Marcos M, Enriquez JA, Nogueiras R, Sabio G. MKK6 controls T3-mediated browning of white adipose tissue. Nat Commun (2017) 8:856
Gonzalez-Teran B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernandez-Cosido L, Mora A, Crainiciuc G, Saiz ML, Bernardo E, Leiva-Vega L, Rodriguez E, Bondia V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G. p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration. EMBO J (2016) 35:536-52
Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Nat Commun (2016) 7:10477
Manieri E, Sabio G. Stress kinases in the modulation of metabolism and energy balance. J Mol Endocrinol (2015) 55:r11-22
Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung D, Kim, JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ. The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway Cell Metab (2014) 20:512-25
Sabio G, Davis RJ. NF and MAP kinase signalling pathways. Seminars in immunology Semin Immunol (2014) 26:237-45
Imbernon M, Beiroa D, Vázquez MJ, Morgan DA, Veyrat-Durebex C, Porteiro B, Díaz-Arteaga A, Senra A, Busquets S, Velásquez DA, Al-Massadi O, Varela L, Gándara M, López-Soriano FJ, Gallego R, Seoane LM, Argiles JM, López M, Davis RJ, Sabio G, Rohner-Jeanrenaud F, Rahmouni K, Dieguez C, Nogueiras R Central Melanin-Concentrating Hormone Influences Liver and Adipose Metabolism Via Specific Hypothalamic Nuclei and Efferent Autonomic/JNK1 Pathways. Gastroenterology (2013) 144:636-49
González-Terán B, Cortés JR, Manieri E, Matesanz N, Verdugo A, Rodríguez ME, González-Rodríguez A, Valverde A, Martín P, Davis RJ, Sabio G. Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis. J Clin Invest (2013) 123:164-78
Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev (2010) 24:256-64
Sabio G, Davis RJ. cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci (2010) 35:490-6
Sabio G, Cerezo-Guisado MI, Del Reino P, Iñesta-Vaquera FA, Rousseau S, Arthur JS, Campbell DG, Centeno F, Cuenda A. p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. J Cell Sci (2010) 123:2596-604
Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol (2010) 10:491-8
Remy G, Risco AM, Iñesta-Vaquera FA, González-Terán B, Sabio G, Davis RJ, Cuenda A. Differential activation of p38MAPK isoforms by MKK6 and MKK3. Cell Signal (2010) 22:660-7
Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 136:249-60
Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab (2009) 10:491-8
Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 322:1483-4
Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M. Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science (2008) 320:667-70