Publicaciones seleccionadas

Santamans AM, Montalvo-Romeral V , Mora A, Lopez JA , González-Romero F, Jimenez-Blasco D , Rodríguez E , Pintor-Chocano A, Casanueva-Benítez C , Acín-Pérez R, Leiva-Vega L , Duran J, Guinovart JJ , Jiménez-Borreguero J, Enríquez JA, Villlalba-Orero M, Bolaños JP, Aspichueta P, Vázquez J , González-Terán B, Sabio G p38gamma and p38delta regulate postnatal cardiac metabolism through glycogen synthase 1 PLoS Biol (2021) 19:e3001447
Nogueiras R, Sabio G Brain JNK and metabolic disease Diabetologia (2021) 64:265-74
Plata-Gómez AB, Crespo M , de la Calle Arregui C, de Prado-Rivas L, Sabio G, Efeyan A Protocol for the assessment of mTOR activity in mouse primary hepatocytes STAR Protoc (2021) 2:100918
Manieri E, Folgueira C, Rodriguez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, Gomez MJ, Monte MJ, JJ GM, Davis RJ, Mora A, Sabio G JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma Proc Natl Acad Sci U S A (2020) 117:16492-9
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Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodriguez E, Leiva-Vega L, Pintor-Chocano A, Fernandez-Chacon M, Ruiz-Garrido I, Cicuendez B, Tomas-Loba A, N AG, Caballero-Molano A, Beiroa D, Hernandez-Cosido L, Torres JL, Kennedy NJ, Davis RJ, Benedito R, Marcos M, Nogueiras R, Hidalgo A, Matesanz N, Leiva M, Sabio G Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism eLife (2020) 9:e59258
Nikolic I, Leiva M, Sabio G The role of stress kinases in metabolic disease Nat Rev Endocrinol (2020) 16:697-716
Tomás-Loba A, Manieri E, González-Terán B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodríguez E, Pintor-Chocano A, Feixas F, López JA, Caballero B, Trakala M, Blanco Ó, Torres JL, Hernández-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, León M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vázquez J, Malumbres M, Marcos M, Osuna S, Sabio G. p38gamma is essential for cell cycle progression and liver tumorigenesis Nature (2019) 568:557-60
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Manieri E, Herrera-Melle L, Mora A, Tomas-Loba A, Leiva-Vega L, Fernandez DI, Rodriguez E, Moran L, Hernandez-Cosido L, Torres JL, Seoane LM, Cubero FJ, Marcos M, Sabio G Adiponectin accounts for gender differences in hepatocellular carcinoma incidence J Exp Med (2019) 216:1108-19
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Matesanz N, Nikolic I, Leiva M, Pulgarin-Alfaro M, Santamans AM, Bernardo E, Mora A, Herrera-Melle L, Rodriguez E, Beiroa D, Caballero A, Martin-Garcia E, Acin-Perez R, Hernandez-Cosido L, Leiva-Vega L, Torres JL, Centeno F, Nebreda AR, Enriquez JA, Nogueiras R, Marcos M, Sabio G. p38alpha blocks brown adipose tissue thermogenesis through p38delta inhibition. PLoS Biol (2018) 16:e2004455
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Matesanz N, Bernardo E, Acin-Perez R, Manieri E, Perez-Sieira S, Hernandez-Cosido L, Montalvo-Romeral V, Mora A, Rodriguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Alvarez CV, Marcos M, Enriquez JA, Nogueiras R, Sabio G. MKK6 controls T3-mediated browning of white adipose tissue. Nat Commun (2017) 8:856
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Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Nat Commun (2016) 7:10477
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Gonzalez-Teran B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernandez-Cosido L, Mora A, Crainiciuc G, Saiz ML, Bernardo E, Leiva-Vega L, Rodriguez E, Bondia V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G. p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration. EMBO J (2016) 35:536-52
González-Terán B, Cortés JR, Manieri E, Matesanz N, Verdugo A, Rodríguez ME, González-Rodríguez A, Valverde A, Martín P, Davis RJ, Sabio G. Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis. J Clin Invest (2013) 123:164-78
Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev (2010) 24:256-64
Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 136:249-60
Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab (2009) 10:491-8
Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 322:1483-4