Selected publications

Herrera-Melle L, Crespo M, Leiva M, Sabio G Stress-activated kinases signaling pathways in cancer development Curr Opin Physiol (2021) 19:22-31
Manieri E, Folgueira C, Rodriguez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, Gomez MJ, Monte MJ, JJ GM, Davis RJ, Mora A, Sabio G JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma Proc Natl Acad Sci U S A (2020) 117:16492-9
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Nikolic I, Leiva M, Sabio G The role of stress kinases in metabolic disease Nat Rev Endocrinol (2020) 16:697-716
Tomás-Loba A, Manieri E, González-Terán B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodríguez E, Pintor-Chocano A, Feixas F, López JA, Caballero B, Trakala M, Blanco Ó, Torres JL, Hernández-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, León M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vázquez J, Malumbres M, Marcos M, Osuna S, Sabio G. p38gamma is essential for cell cycle progression and liver tumorigenesis Nature (2019) 568:557-60
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Manieri E, Herrera-Melle L, Mora A, Tomas-Loba A, Leiva-Vega L, Fernandez DI, Rodriguez E, Moran L, Hernandez-Cosido L, Torres JL, Seoane LM, Cubero FJ, Marcos M, Sabio G Adiponectin accounts for gender differences in hepatocellular carcinoma incidence J Exp Med (2019) 216:1108-19
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Quinones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tovolli R, Garcia-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Ferno J, Malagon MM, Contreras R, Pfluger P, Bruning JC, Yeo G, Tschop M, Dieguez C, Lopez M, Claret M, Kloppenburg P, Sabio G, Nogueiras R. p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nat Commun (2018) 9:3432
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Notario L, Alari-Pahissa E, Albentosa A, Leiva M, Sabio G, Lauzurica P. Anti-CD69 therapy induces rapid mobilization and high proliferation of HSPCs through S1P and mTOR. Leukemia (2018) 32:1445-57
Matesanz N, Nikolic I, Leiva M, Pulgarin-Alfaro M, Santamans AM, Bernardo E, Mora A, Herrera-Melle L, Rodriguez E, Beiroa D, Caballero A, Martin-Garcia E, Acin-Perez R, Hernandez-Cosido L, Leiva-Vega L, Torres JL, Centeno F, Nebreda AR, Enriquez JA, Nogueiras R, Marcos M, Sabio G. p38alpha blocks brown adipose tissue thermogenesis through p38delta inhibition. PLoS Biol (2018) 16:e2004455
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Matesanz N, Bernardo E, Acin-Perez R, Manieri E, Perez-Sieira S, Hernandez-Cosido L, Montalvo-Romeral V, Mora A, Rodriguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Alvarez CV, Marcos M, Enriquez JA, Nogueiras R, Sabio G. MKK6 controls T3-mediated browning of white adipose tissue. Nat Commun (2017) 8:856
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Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Nat Commun (2016) 7:10477
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Gonzalez-Teran B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernandez-Cosido L, Mora A, Crainiciuc G, Saiz ML, Bernardo E, Leiva-Vega L, Rodriguez E, Bondia V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G. p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration. EMBO J (2016) 35:536-52
Manieri E, Sabio G. Stress kinases in the modulation of metabolism and energy balance. J Mol Endocrinol (2015) 55:r11-22
Sabio G, Davis RJ. NF and MAP kinase signalling pathways. Seminars in immunology Semin Immunol (2014) 26:237-45
González-Terán B, Cortés JR, Manieri E, Matesanz N, Verdugo A, Rodríguez ME, González-Rodríguez A, Valverde A, Martín P, Davis RJ, Sabio G. Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis. J Clin Invest (2013) 123:164-78
Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev (2010) 24:256-64
Sabio G, Cerezo-Guisado MI, Del Reino P, Iñesta-Vaquera FA, Rousseau S, Arthur JS, Campbell DG, Centeno F, Cuenda A. p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. J Cell Sci (2010) 123:2596-604
Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol (2010) 10:491-8
Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 136:249-60
Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab (2009) 10:491-8
Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 322:1483-4