Selected publications

    Crespo M, Nikolic I, Mora A, Rodríguez E, Leiva-Vega L, Pintor-Chocano A, Horrillo D, Hernández-Cosido L, Torres JL, Novoa E, Nogueiras R, Medina-Gómez G, Marcos M, Leiva M, Sabio G. Myeloid p38 activation maintains macrophage-liver crosstalk and BAT thermogenesis through IL-12-FGF21 axis. Hepatology (2022) May 19 [Epub ahead of print]
    Link to the full text in Repisalud
    Romero-Becerra R, Mora A, Manieri E, Nikolic I, Santamans AM, Montalvo-Romeral V, Cruz FM, Rodríguez E, León M, Leiva-Vega L, Sanz L, Bondía V, Filgueiras-Rama D, Jiménez-Borreguero LJ, Jalife J, Gonzalez-Teran B, Sabio G. MKK6 deficiency promotes cardiac dysfunction through MKK3-p38gamma/delta-mTOR hyperactivation. eLife (2022) 11
    Link to the full text in Repisalud
    Santamans AM, Montalvo-Romeral V , Mora A, Lopez JA , González-Romero F, Jimenez-Blasco D , Rodríguez E , Pintor-Chocano A, Casanueva-Benítez C , Acín-Pérez R, Leiva-Vega L , Duran J, Guinovart JJ , Jiménez-Borreguero J, Enríquez JA, Villlalba-Orero M, Bolaños JP, Aspichueta P, Vázquez J , González-Terán B, Sabio G p38gamma and p38delta regulate postnatal cardiac metabolism through glycogen synthase 1 PLoS Biol (2021) 19:e3001447
    Nogueiras R, Sabio G Brain JNK and metabolic disease Diabetologia (2021) 64:265-74
    Plata-Gómez AB, Crespo M , de la Calle Arregui C, de Prado-Rivas L, Sabio G, Efeyan A Protocol for the assessment of mTOR activity in mouse primary hepatocytes STAR Protoc (2021) 2:100918
    Manieri E, Folgueira C, Rodriguez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, Gomez MJ, Monte MJ, JJ GM, Davis RJ, Mora A, Sabio G JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma Proc Natl Acad Sci U S A (2020) 117:16492-9
    Link to the full text in Repisalud
    Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodriguez E, Leiva-Vega L, Pintor-Chocano A, Fernandez-Chacon M, Ruiz-Garrido I, Cicuendez B, Tomas-Loba A, N AG, Caballero-Molano A, Beiroa D, Hernandez-Cosido L, Torres JL, Kennedy NJ, Davis RJ, Benedito R, Marcos M, Nogueiras R, Hidalgo A, Matesanz N, Leiva M, Sabio G Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism eLife (2020) 9:e59258
    Nikolic I, Leiva M, Sabio G The role of stress kinases in metabolic disease Nat Rev Endocrinol (2020) 16:697-716
    Tomás-Loba A, Manieri E, González-Terán B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodríguez E, Pintor-Chocano A, Feixas F, López JA, Caballero B, Trakala M, Blanco Ó, Torres JL, Hernández-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, León M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vázquez J, Malumbres M, Marcos M, Osuna S, Sabio G. p38gamma is essential for cell cycle progression and liver tumorigenesis Nature (2019) 568:557-60
    Link to the full text in Repisalud
    Manieri E, Herrera-Melle L, Mora A, Tomas-Loba A, Leiva-Vega L, Fernandez DI, Rodriguez E, Moran L, Hernandez-Cosido L, Torres JL, Seoane LM, Cubero FJ, Marcos M, Sabio G Adiponectin accounts for gender differences in hepatocellular carcinoma incidence J Exp Med (2019) 216:1108-19
    Link to the full text in Repisalud
    Matesanz N, Nikolic I, Leiva M, Pulgarin-Alfaro M, Santamans AM, Bernardo E, Mora A, Herrera-Melle L, Rodriguez E, Beiroa D, Caballero A, Martin-Garcia E, Acin-Perez R, Hernandez-Cosido L, Leiva-Vega L, Torres JL, Centeno F, Nebreda AR, Enriquez JA, Nogueiras R, Marcos M, Sabio G. p38alpha blocks brown adipose tissue thermogenesis through p38delta inhibition. PLoS Biol (2018) 16:e2004455
    Link to the full text in Repisalud
    Matesanz N, Bernardo E, Acin-Perez R, Manieri E, Perez-Sieira S, Hernandez-Cosido L, Montalvo-Romeral V, Mora A, Rodriguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Alvarez CV, Marcos M, Enriquez JA, Nogueiras R, Sabio G. MKK6 controls T3-mediated browning of white adipose tissue. Nat Commun (2017) 8:856
    Link to the full text in Repisalud
    Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Nat Commun (2016) 7:10477
    Link to the full text in Repisalud
    Gonzalez-Teran B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernandez-Cosido L, Mora A, Crainiciuc G, Saiz ML, Bernardo E, Leiva-Vega L, Rodriguez E, Bondia V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G. p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration. EMBO J (2016) 35:536-52
    González-Terán B, Cortés JR, Manieri E, Matesanz N, Verdugo A, Rodríguez ME, González-Rodríguez A, Valverde A, Martín P, Davis RJ, Sabio G. Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis. J Clin Invest (2013) 123:164-78
    Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev (2010) 24:256-64
    Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 136:249-60
    Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab (2009) 10:491-8
    Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 322:1483-4

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