A rotor organizing atrial fibrillation in a sheep heart

    A rotor organizing atrial fibrillation in a sheep heart.


    Channelosomes formed by NaV1.5 and Kir2.1 at different membrane microdomains of the cardiomyocyte

    Channelosomes formed by NaV1.5 and Kir2.1 at different membrane microdomains of the cardiomyocyte. A.
    The NaV1.5-syntrophin-Kir2.1 channelosome. B. The NaV1.5-SAP97-Kir2.1 channelosome.

     

    Molecular partners of trafficking and localization of NaV1.5 and Kir2.1 in the cardiac myocyte

    Molecular partners of trafficking and localization of NaV1.5 and Kir2.1 in the cardiac myocyte. 1, transcription; 2, translation; 3, Golgi-mediated glycosylation; 4, vesicular trafficking; 5, compartmental localization and function; 6, retrograde vesicular trafficking, protein degradation, and recycling. Evidence supports interaction at the membrane through SAP97, syntrophin and AP1.2