A rotor organizing atrial fibrillation in a sheep heart.
Channelosomes formed by NaV1.5 and Kir2.1 at different membrane microdomains of the cardiomyocyte. A.
The NaV1.5-syntrophin-Kir2.1 channelosome. B. The NaV1.5-SAP97-Kir2.1 channelosome.
Molecular partners of trafficking and localization of NaV1.5 and Kir2.1 in the cardiac myocyte. 1, transcription; 2, translation; 3, Golgi-mediated glycosylation; 4, vesicular trafficking; 5, compartmental localization and function; 6, retrograde vesicular trafficking, protein degradation, and recycling. Evidence supports interaction at the membrane through SAP97, syntrophin and AP1.2