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    E.g., 17/08/2025
    E.g., 17/08/2025
    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research
    29 Nov 2022
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart
    Cellular and Molecular Sciences: Describen un nuevo mecanismo que relaciona la inflamación y el remodelado cardiovascular patológico
    Research
    29 Sep 2022
    Cellular and Molecular Sciences: Describing a new mechanism that links inflammation and pathological cardiovascular remodelling
    About the CNIC
    23 Aug 2022
    Cell Stem Cell: Researchers at CNIC, UPF, ICREA, CIBERNED and CIBERFES identify a mechanism that maintains mitochondria function in muscle stem cells and that can be stimulated in old age

    The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people
    Embrión de ratón con el gen Hoxb1 expresado de forma normal (izquierda) y embrión de ratón donde se expresa fuera de lugar (derecha) por la acción de Oct4
    Research
    14 Jul 2022
    Science Advances: The genes that give the embryonic cells the maximum potential also control the process of their differentiation.
    Una cámara térmica muestra el efecto de la IL-12 sobre la grasa parda en ratón.
    Research
    9 Jun 2022
    Hepatology: Immune cells in the liver regulate body temperature

    A study published in Hepatology demonstrates that the activation of thermogenesis in the livers of obese mice contributes to weight loss and improves diabetes symptoms
    Macaca
    Research
    18 Apr 2022
    Nature: International Team Led by BGI Completes First Whole-Body Cell Atlas of a Non-Human Primate

    The research will provide insights into the development of potential treatments for neurological diseases and obesity, among other human conditions
    María García García, Miguel Ángel del Pozo Barriuso, Sara Sánchez Perales, Laura Sotodosos-Alonso, Enrique Calvo, Jesús Vázquez y Asier Echarri
    Research
    3 Mar 2022
    Nature Communications: CNIC scientists identify a shuttle protein required for the nuclear import of proteins essential for organ growth and development

    Most biological processes require the import to the cell nucleus of key regulatory factors; one of the most important of these factors is the protein YAP
    José Javier Fuster
    About the CNIC
    23 Feb 2022
    Nature Cardiovascular Research: Mutations acquired by blood cells are an indicator of cardiovascular risk

    Researchers from the CNIC and Columbia University (USA) review the role of acquired mutations and clonal hematopoiesis in cardiovascular disease
    Miguel Palomino Segura, Georgiana Crainiciuc, Jon Sicilia y Andrés Hidalgo
    Research
    5 Jan 2022
    Nature: CNIC scientists discover a cell behavior pattern that predicts cardiovascular disease

    Scientists at the CNIC have developed a simple model for studying the behavior of immune cells in live animals and have identified a harmful cell behavior pattern associated with cardiovascular disease
    Daño local en las fibras musculares tras el ejercicio. Visualización del daño local en fibras de músculo esquelético (soleous y gastro) de ratón joven tras el ejercicio, mediante la tinción con marcadores de daño local como Filamina C (verde) y Evans Blue (rojo), y los núcleos (en azul) de fibras.
    Research
    18 Oct 2021
    Science: A rapid mechanism for muscle self-repair independent of stem cells

    Researchers from the National Center for Cardiovascular Research and the Pompeu Fabra University describe in Science a new mechanism for muscle regeneration after physiological damage