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    E.g., 17/03/2026
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    Research
    5 Feb 2026
    EHJP: Beta-blockers provide no benefit after myocardial infarction, either in the acute or chronic phase

    A prespecified landmark analysis of the REBOOT trial, published in The European Heart Journal Cardiovascular Pharmacotherapy, shows no clinical benefit of beta-blockers during the first year after infarction or beyond one year, in patients without reduced ejection fraction.
    CNIC-led REBOOT clinical trial challenges 40-year-old standard of care for heart attack patients
    Research
    30 Aug 2025
    NEJM & The Lancet: CNIC-led REBOOT clinical trial challenges 40-year-old standard of care for heart attack patients

    REBOOT trial, coordinated by the CNIC, shows that treatment with beta-blockers provides no benefit to patients who experience an uncomplicated heart attack that leaves the contractile function of the heart intact.
    About the CNIC
    6 Aug 2021
    RREBOOT, on a mission to change clinical practice guidelines for the treatment of heart attack survivors

    CNIC and the Mario Negri Institute in Milan (Italy) coordinate REBOOT, a project that aims to study whether treatment with beta-blockers is beneficial for patients who have suffered a myocardial infarction