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    E.g., 07/06/2025
    E.g., 07/06/2025
    Dr. García Pavía
    Research
    21 May 2023
    NEJM: A Spanish team presents the first pharmacological treatment able to improve cardiac function in stiff-heart syndrome

    The team led by Dr. Pablo García-Pavía, based at the CNIC and Hospital Puerta de Hierro, has published the first study of a drug able to remove amyloid deposits from the heart

    Imágenes del corazón obtenidas mediante resonancia magnética en las que se analizan distintas estructuras de la anatomía y función del corazón: aurículas (paneles A y B), ventrículos (paneles C y D), características del tejido cardiaco (paneles E y F).
    Research
    3 Mar 2023
    eClinicalMedicine: Imaging the adolescent heart

    The results, published in eClinicalMedicine, have direct implications for clinical practice by providing a list of reference values for a multitude of cardiac parameters used in daily practice
    Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
    Research
    23 Dec 2022
    Nature Cell Biology: A CNIC study shows that cells possess 2 mechanisms to allow them to respond to different force ranges

    A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces
    La figura muestra imágenes mediante resonancia magnética cardíaca (A y B) y tomografía computarizada (C y D) de un corazón en diástole (A y C) y sístole (B y D) para el cálculo de la función de ambos ventrículos. VD: Ventrículo derecho; VI: Ventrículo izquierdo.
    Research
    12 Dec 2022
    European Journal of Heart Failure: A promising drug treatment for patients with pulmonary hypertension associated with heart disease

    The results of the SPHERE-HF study are published in the European Journal of Heart Failure. SPHERE-HF is a multicenter academic clinical trial led by investigators at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona
    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research
    29 Nov 2022
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart
    Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
    Research
    7 Nov 2022
    Circulation: Specific modifier genes determine the effect of mutations that cause non-compaction cardiomyopathy

    A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes

    Descubren un factor clave que protege el corazón tras un infarto
    About the CNIC
    2 Nov 2022
    JCI: CNIC scientists identify a factor that protects the heart against damage after a heart attack

    A new study defines a mechanism that regulates inflammation after a myocardial infarction, opening a path to the use of the receptor

    Participants who followed the TANSNIP-PESA program (orange line) showed an improvement in lifestyle measures and cardiovascular health compared with participants in the control group (who did not participate in the intervention; blue line). The Y-axis shows changes in the Fuster -BEWAT lifestyle and cardiovascular risk score with respect to the baseline value.
    Research
    26 Jul 2022
    European Heart Journal: “One change a day makes 365 changes in a year”

    Adherence to a workplace cardiovascular health-promotion program improves lifestyle and risk factors in healthy individuals
    Dr. Pablo García-Pavía y Dr. Jesús Gonzalez Mirelis, codirectores del trabajo.
    Research
    22 Jul 2022
    EJHF: Spanish scientists combine genetic and imaging data to improve the treatment of dilated cardiomyopathy

    Genetic screening combined with the detection of fibrosis identifies patients at risk of malignant arrhythmias or developing heart failure with severe complications
    Microfotografía de una monocapa de cardiomiocitos derivados de células madre inducidas a la pluripotencia, representativa de las que se usaron para estudiar los mecanismos de arritmias y el rescate de la función normal por el gen que codifica a la sintrofina-α
    Research
    29 Jun 2022
    eLife: Study reveals how Duchenne muscular dystrophy causes heart rhythm problems

    Investigadores del CNIC  revelan por primera los mecanismos moleculares que subyacen a las arritmias que ocurren en pacientes que padecen “Distrofia Muscular de Duchenne”