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    E.g., 16/06/2025
    E.g., 16/06/2025
    Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
    Research
    13 Dec 2022
    eLife:CNIC scientists identify the essential role of cell-surface "nanofolds" and "glue" in the mechanical response of cells

    A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins
    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research
    29 Nov 2022
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart
    Cellular and Molecular Sciences: Describen un nuevo mecanismo que relaciona la inflamación y el remodelado cardiovascular patológico
    Research
    29 Sep 2022
    Cellular and Molecular Sciences: Describing a new mechanism that links inflammation and pathological cardiovascular remodelling
    About the CNIC
    23 Aug 2022
    Cell Stem Cell: Researchers at CNIC, UPF, ICREA, CIBERNED and CIBERFES identify a mechanism that maintains mitochondria function in muscle stem cells and that can be stimulated in old age

    The finding provides a basis for mitigating the loss of muscle regenerative capacity in elderly people
    Embrión de ratón con el gen Hoxb1 expresado de forma normal (izquierda) y embrión de ratón donde se expresa fuera de lugar (derecha) por la acción de Oct4
    Research
    14 Jul 2022
    Science Advances: The genes that give the embryonic cells the maximum potential also control the process of their differentiation.
    Andrés Hidalgo
    About the CNIC
    6 Jul 2022
    Dr. Andrés Hidalgo elected a member of the European Molecular Biology Organization – EMBO

    Through this lifelong honour, new EMBO Members and Associate Members are recognized for their outstanding achievements in the life sciences
    Una cámara térmica muestra el efecto de la IL-12 sobre la grasa parda en ratón.
    Research
    9 Jun 2022
    Hepatology: Immune cells in the liver regulate body temperature

    A study published in Hepatology demonstrates that the activation of thermogenesis in the livers of obese mice contributes to weight loss and improves diabetes symptoms
    An optical section from a ventral view of a mouse embryo at embryonic day E8.0. The section is overlain with a cast of the three-dimensional shape of the forming heart (red) and the incipient circulatory system (purple).
    Research
    17 May 2022
    Nature Cardiovascular Research: A CNIC team creates a dynamic 3D atlas of the formation of the embryonic heart

    The 3D atlas has allowed the scientists to identify the beginning of left–right asymmetry in the heart
    Macaca
    Research
    18 Apr 2022
    Nature: International Team Led by BGI Completes First Whole-Body Cell Atlas of a Non-Human Primate

    The research will provide insights into the development of potential treatments for neurological diseases and obesity, among other human conditions
    María García García, Miguel Ángel del Pozo Barriuso, Sara Sánchez Perales, Laura Sotodosos-Alonso, Enrique Calvo, Jesús Vázquez y Asier Echarri
    Research
    3 Mar 2022
    Nature Communications: CNIC scientists identify a shuttle protein required for the nuclear import of proteins essential for organ growth and development

    Most biological processes require the import to the cell nucleus of key regulatory factors; one of the most important of these factors is the protein YAP