Guadalupe Sabio graduated from the School of Veterinary Medicine at the Universidad de Extremadura in 2000. Her PhD, under the direction of Dr. Ana Cuenda, was conducted both at the Universidad de Extremadura and at the MRC Protein Phosphorylation Unit in Dundee, UK. Her thesis work demonstrated the redundant function of p38-gamma and p38 delta, and showed that both kinases can phosphorylate SAP97 and SAP90.
For her postdoc Guadalupe moved to the University of Massachusetts Medical School (Worcester, MA), to work with Dr. Roger Davis. Her work in this period focused on the tissue-specific roles of JNK1, using mice with conditional deletion of JNK1 in different tissues. Through this work she was able to make important contributions to the understanding of the tissue-specific roles of JNK1 and its implication in the pathogenesis of type II diabetes.
Guadalupe returned to Spain in 2009 with a Ramón y Cajal contract to study diseases associated with obesity (diabetes, cardiovascular disease and cancer). She joined the CNIC in 2011.