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Catarina Tristão Pereira, Enrique Lara Pezzi, Raquel Toribio Fernández, Borja Ibáñez, Valentín Fuster, Sergio Callejas, Marta Cortés Canteli, Ana Dopazo, Pilar Martín, Inés García Lunar e Irene Fernández Nueda.
Research
23 Jan 2024

The most potent genetic risk factor for Alzheimer disease, APOE4, is associated with an elevated risk of developing subclinical atherosclerosis in middle age, whereas the Alzheimer-protective variant of the same gene, APOE2, protects against subclinical atherosclerosis

Marcos Siguero Álvarez, Luis Luna Zurita, José Luis de la Pompa y Brenda Giselle Flores Garza
Research
11 Dec 2023

The findings, published in the journal Circulation Research, not only highlight the gene regulatory mechanisms that control valve formation, but also offer clues for future medical advances


Neuregulin-1 induces changes in actin filaments during ventricular maturation. Actinin staining of a mouse embryo heart reveals a striated actin pattern corresponding to mature trabecular sarcomeres (green). The magnified view shows the differences in luminosity that distinguish the more organized actin filaments of the trabecular myocardium from the less organized compact layer
Research
10 Nov 2023

Neuregulin-1 (Nrg1) plays an essential role in the transformation of the heart from its delicate primordial structure into the powerful beating mature organ 

Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
Research
7 Nov 2022

A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes

Research
17 Mar 2022

The mixing of mitochondrial DNAs (mtDNAs) of two distinct origins can have damaging medium- and long-term effects, according to the results of a new study published in Circulation

Álvaro Macías, Jesús Vázquez, Pilar Gonzalo, Carla Espinós, Beatriz Dorado, Emilio Camafeita, Vicente Andrés, María J Andrés, Cristina González, Amanda Sánchez, Víctor Fanjul.
Research
26 Oct 2021

Scientists from the CNIC and the CIBERCV have generated the first experimental animal model that develops Hutchinson-Gilford Progeria Syndrome and allows its controlled reversal


De izquierda a derecha: Enrique Lara-Pezzi, Laura Lalaguna, Laura Ramos, Elena González, María Villalba, Claudia Camarero, Marina López, Betel Olaizola, Ascensión Rey, Carlos Martí, Elísabet Bello y Javier Larrasa
Research
3 Sep 2021

The new findings, published in Circulation Research, could spur the development of new tools for the treatment of cardiac hypertrophy

Primera fila:  Irene Fernández-Nueda, Marta Cortés-Canteli, Valentín Fuster, Ana Marcos-Díaz y Borja Ibáñez. Detrás: Javier Sánchez-González, Carlos Cerón y Sergio Callejas.
Research
9 Oct 2019

Treatment of mice for 12 months with the anticoagulant drug dabigatran prevented memory loss and preserved cerebral circulation

Atrial electroanatomic map of a pig with persistent AFib. The regions colored magenta, purple, and dark blue have high mean FM values. These regions maintain the AFib, and their ablation with a catheter stops the arrhythmia. The squares represent the sites of rotational activity, which are sensitive but not specific to the regions that maintain the fibrillation.
Research
12 Sep 2019

The new study was conducted by investigators at the CNIC, the Hospital Clínico San Carlos in Madrid, and the CiberCV research network and is featured on the cover of the latest edition of the journal Circulation Research

From left to right: Marta Román, Fernando Domínguez, Laura Padrón-Barthe, Pablo Garcia-Pavia, Giovanna Giovinazzo, Enrique Lara-Pezzi, Demetrio J. Santiago, Javier Larrasa-Alonso
Research
5 Sep 2019

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Puerta de Hierro hospital in Majadahonda have found a possible treatment for this disease