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E.g., 11/10/2024
E.g., 11/10/2024
Cardiovascular risk factors (particularly metabolic syndrome, insulin resistance, and diabetes) alter coronary microvascular function and increase the risk of atherosclerotic disease, which itself leads to changes in the coronary microcirculation.
Research
19 Sep 2024

A study from CNIC reveals how risk factors and subclinical atherosclerosis affect heart microcirculation in asymptomatic middle-aged individuals. The research, published in JACC: Cardiovascular Imaging, highlights the importance of assessing the heart vessels' ability to regulate blood flow and predict future cardiovascular risk

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Research
9 Sep 2024

The new study, published in the journal Circulation, opens a new avenue of research into treatments for the atherosclerosis associated with progeria

María Jesús Andrés, Carla Espinós (detrás), Rosa M Nevado (delante, al lado de MJA), Miguel de la Fuente, Rosa Carmona, Ana Barettino, Vicente Andrés, Pilar Gonzalo e Ignacio Benedicto.
Research
19 Apr 2024

The elimination of progerin from vascular smooth muscle cells, but not from endothelial cells, prevents the atherosclerosis associated with Hutchinson-Gilford progeria syndrome (HGPS)

María Linarejos Vera, Gema Mondéjar, Amaia Talavera, Patricia Sánchez, Álvaro Macías, Juan Manuel Ruiz, Francisco M. Cruz, Fernando Martínez de Benito, Juan Antonio Bernal y José Jalife
Research
11 Apr 2024

CNIC researchers, led by Dr. José Jalife, have made a key discovery about cardiac arrhythmias in Andersen-Tawil syndrome (ATS)

Catarina Tristão Pereira, Enrique Lara Pezzi, Raquel Toribio Fernández, Borja Ibáñez, Valentín Fuster, Sergio Callejas, Marta Cortés Canteli, Ana Dopazo, Pilar Martín, Inés García Lunar e Irene Fernández Nueda.
Research
23 Jan 2024

The most potent genetic risk factor for Alzheimer disease, APOE4, is associated with an elevated risk of developing subclinical atherosclerosis in middle age, whereas the Alzheimer-protective variant of the same gene, APOE2, protects against subclinical atherosclerosis

Marcos Siguero Álvarez, Luis Luna Zurita, José Luis de la Pompa y Brenda Giselle Flores Garza
Research
11 Dec 2023

The findings, published in the journal Circulation Research, not only highlight the gene regulatory mechanisms that control valve formation, but also offer clues for future medical advances


Neuregulin-1 induces changes in actin filaments during ventricular maturation. Actinin staining of a mouse embryo heart reveals a striated actin pattern corresponding to mature trabecular sarcomeres (green). The magnified view shows the differences in luminosity that distinguish the more organized actin filaments of the trabecular myocardium from the less organized compact layer
Research
10 Nov 2023

Neuregulin-1 (Nrg1) plays an essential role in the transformation of the heart from its delicate primordial structure into the powerful beating mature organ 

Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
Research
7 Nov 2022

A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes

Research
17 Mar 2022

The mixing of mitochondrial DNAs (mtDNAs) of two distinct origins can have damaging medium- and long-term effects, according to the results of a new study published in Circulation

Álvaro Macías, Jesús Vázquez, Pilar Gonzalo, Carla Espinós, Beatriz Dorado, Emilio Camafeita, Vicente Andrés, María J Andrés, Cristina González, Amanda Sánchez, Víctor Fanjul.
Research
26 Oct 2021

Scientists from the CNIC and the CIBERCV have generated the first experimental animal model that develops Hutchinson-Gilford Progeria Syndrome and allows its controlled reversal