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E.g., 03/02/2023
Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
Research
23 Dec 2022

A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces

Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
Research
13 Dec 2022

A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins

La figura muestra imágenes mediante resonancia magnética cardíaca (A y B) y tomografía computarizada (C y D) de un corazón en diástole (A y C) y sístole (B y D) para el cálculo de la función de ambos ventrículos. VD: Ventrículo derecho; VI: Ventrículo izquierdo.
Research
12 Dec 2022

The results of the SPHERE-HF study are published in the European Journal of Heart Failure. SPHERE-HF is a multicenter academic clinical trial led by investigators at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona

Los complejos I, III, y IV de la cadena de transporte electrónico mitocondrial se asocian formando grandes estructuras llamadas supercomplejos.  SCAF1 determina la asociación entre complejos de la cadena de transporte mitocondrial.
Research
18 Oct 2022

A study, published in Nature Metabolism, is the first to demonstrate the key role played by mitochondria in adapting metabolism to different energy demands in humans

Imagen obtenida por microscopía confocal en la que se observa el borde de la cicatriz glial producida tras el infarto cerebral, lo cual dificulta la posterior regeneración de la zona. Este evento es atenuado en gran medida a través del tratamiento con metoprolol intravenoso pre-reperfusión.
Research
3 Oct 2022

Metoprolol, an established drug in the cardiologists armory, protects the brain during a stroke and greatly reduces its consequences


Pablo García Pavía and Luis Escobar
Research
12 Sep 2022

The findings, published in the Journal of the American College of Cardiology (JACC), will enable physicians to make appropriate treatment adjustments for patients with this disease


Los adolescentes que duermen menos de 8 horas tienen más probabilidades de tener sobrepeso u obesidad
Research
29 Aug 2022

Excess weight and metabolic syndrome are associated with cardiovascular disease, suggesting that health promotion programs in schools should teach good sleep habits

Fernando de Frutos y el Dr. Pablo García Pavía.
Research
29 Aug 2022

The findings, published in the Journal of the American College of Cardiology (JACC), represent a first step towards the personalized treatment of patients with this disease

Valentín Fuster
Research
26 Aug 2022

The results of the SECURE trial, coordinated by CNIC were presented in a Hot Line session at the European Society of Cardiology meeting (ESC 2022) in Barcelona and published at the NEJM

Imagen de histología que muestra la comparación del tamaño del corazón de un ratón normal (izquierda) y un ratón deficiente para la proteína MKK6 (derecha).
Research
9 Aug 2022

A new study published in eLife shows that inhibition of p38γ/δ is a potential therapeutic strategy for the treatment of hypertrophic cardiomyopathy, but that this strategy has yet to be explored because of the lack of specific inhibitors for these p38 family members