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    E.g., 18/06/2024
    E.g., 18/06/2024
    Skeletal staining of the inferior limb regions of normal embryos, embryos with a single Meis allele, and an embryo with complete absence of Meis. Embryos with a single copy of Meis lack the fibula and posterior digits (black arrow). Total absence of Meis prevents limb development (white arrow).
    Research
    2 Jun 2021
    Nature Communications: CNIC scientists identify essential factors for limb formation

    The study, published in Nature Communications, reveals that Meis transcription factors are essential for the formation and antero-posterior patterning of the limbs during embryonic development 

    Sara Martínez Martínez, María José Méndez Olivares, Álvaro Alfayate, , Andrea de la Fuente-Alonso, Miguel R. Campanero, Juan Miguel Redondo y Jesús Vázquez.
    Research
    11 May 2021
    Nature Communications: Inhibition of proteins activated by nitric oxide reverses aortic aneurysm in Marfan syndrome

    Scientists at the CNIC and CSIC have shown that elevated activity of proteins regulated by nitric oxide (NO) causes the aortic disease seen in Marfan Syndrome patients
    De izda. a dcha.: Verónica Casquero, Sofía Sánchez, Irene García, Macarena Fernández, Wen Luo, Severin Muhleder, Lourdes García, Rui Benedito
    Research
    9 Dec 2020
    Nature: A new way to make arteries

    Científicos del CNIC han descubierto un mecanismo celular y molecular que puede ayudar a promover la arterialización y perfusión en los tejidos que han sufrido una reducción del riego sanguíneo.
    Jesús Vázquez, Almudena Ramiro, José Luis Martín Ventura, Inmaculada Martos Folgado, Cristina Lorenzo y Sonia Mur.
    Research
    2 Dec 2020
    Nature: CNIC scientists identify a new diagnostic and therapeutic target for cardiovascular disease

    Un estudio que se publica en Nature muestra a la proteína mitocondrial ALDH4A1 como un nuevo autoantígeno implicado en los procesos de la aterosclerosis
    Research
    27 Oct 2020
    Nature Cell Biology: Researchers identify a subgroup of stem cells that resists ageing and maintains muscle regeneration capacity until geriatric age

    The finding provides a basis for mitigating the loss of muscle regenerative capacity in very elderly people.
    Research
    16 Oct 2020
    Nature Reviews Endocrinology: Protein kinases could be the next target in the treatment of diseases associated with obesity

    Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) review the roles of a groups of proteins called stress kinases in metabolism in an article published in Nature Reviews Endocrinology
    Research
    17 Sep 2020
    Nature Metabolism: CNIC researchers discover a mechanism allowing immune cells to regulate obesity

    The results published in Nature Metabolism could be useful to design new treatments for the obese and overweight, and for some associated pathologies, including fatty liver disease and type 2 diabetes
    Research
    30 Jul 2020
    Nature: Scientists at the CNIC and IIS Princesa decipher a key mechanism in hypoxia

    The study, published in Nature, shows that sodium controls hypoxic signaling in the mitochondrial respiratory chain
    Research
    25 Jun 2020
    Science Advances: CNIC scientists identify the mechanism that regulates mitochondrial energy production

    The regulatory protein SCAF1 enables mitochondria to adapt to the available nutrient source of sugars, fats, or proteins
    Research
    28 Apr 2020
    Nature Communications: CNIC scientists design an experimental mouse model for investigating the mechanical function of proteins in vivo

    CNIC scientists, working with international partners, have developed a new experimental mouse model that allows them to study how cells sense, interpret, and generate mechanical forces