Selected publications

    Menendez-Montes I, Marin-Vicente C, Mukherjee S, Ahmed MS, Gomez MJ, Anene-Nzelu CG, Lee CJM, Koslowski S, Solmonson A, Tassin T, Ali SR, Pessoa P, Elnwasany A, Lam NT, Thet S, Calvo E, Cardoso AC, Pereira AHM, Xiao F, Wang P, Mohamed A, El-Feky H, Elghamry A, Gancedo-Alonso G, Nguyen NUN, Hsu CC, Westfall AK, DeBerardinis R, Foo RS, Kinter M, Pressé S, Xing C, Szweda L, Aroumougame A, Sanchez-Cabo F, Enriquez JA, Torres M, Vazquez J, Sadek HA. Mitochondria directly interact with the nuclear pore complex. Nature (2026) 654:786-797
    Link to the full text in Repisalud
    Henry TD, Chung ES, Alvisi M, Sethna F, Murray DR, Traverse JH, Roessig L, Roberts L, Reddy S, Chen Y, Ozkan TG, Webb S, Mittal M, Ervin L, Sadek H, Mikhail S, Haghighi K, Jiang C, Samulski RJ, Kranias EG, Tretiakova AP, Hajjar RJ. Cardiotropic AAV gene therapy for heart failure: a phase 1 trial. Nat Med (2025) 31:3845-3852
    Lam NT, Nguyen NUN, Elhelaly WM, Hsu CC, Menendez-Montes I, Xiao F, Ali SR, Vo N, Briard N, El-Feky L, Omari QM, Cardoso AC, Liu Y, Ahmed MS, Li S, Thet S, Xing C, Zangi L, Sadek HA. Induced Cytokinesis Generates Highly Proliferative Mononuclear Cardiomyocytes at the Expense of Contractility. Circulation (2025) 151:1009-1023
    Derks W, Rode J, Collin S, Rost F, Heinke P, Hariharan A, Pickel L, Simonova I, Lázár E, Graham E, Jashari R, Andrä M, Jeppsson A, Salehpour M, Alkass K, Druid H, Kyriakopoulos CP, Taleb I, Shankar TS, Selzman CH, Sadek H, Jovinge S, Brusch L, Frisén J, Drakos S, Bergmann O. A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease. Circulation (2025) 151:245-256
    Wang P, Ahmed MS, Nguyen NUN, Menendez-Montes I, Hsu CC, Farag AB, Thet S, Lam NT, Wansapura JP, Crossley E, Ma N, Zhao SR, Zhang T, Morimoto S, Singh R, Elhelaly W, Tassin TC, Cardoso AC, Williams NS, Pointer HL, Elliott DA, McNamara JW, Watt KI, Porrello ER, Sadayappan S, Sadek HA. An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models. J Clin Invest (2025) 135:e174081
    Link to the full text in Repisalud
    Xiao F, Nguyen NUN, Wang P, Li S, Hsu CC, Thet S, Kimura W, Luo X, Lam NT, Menendez-Montes I, Elhelaly W, Cardoso AC, Pereira AHM, Singh R, Sadayappan S, Kanchwala M, Xing C, Ladha FA, Hinson JT, Hajjar RJ, Hill JA, Sadek HA. Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis. Circulation (2024) 150:791-805
    Link to the full text in Repisalud
    Ahmed MS, Nguyen NUN, Nakada Y, Hsu CC, Farag A, Lam NT, Wang P, Thet S, Menendez-Montes I, Elhelaly WM, Lou X, Secco I, Tomczyk M, Zentilin L, Pei J, Cui M, Dos Santos M, Liu X, Liu Y, Zaha D, Walcott G, Tomchick DR, Xing C, Zhang CC, Grishin NV, Giacca M, Zhang J, Sadek HA. Identification of FDA-approved drugs that induce heart regeneration in mammals. Nature Cardiovascular Research (2024) 3:372-388
    Link to the full text in Repisalud
    Lam NT, Nguyen NUN, Ahmed MS, Hsu CC, Rios Coronado PE, Li S, Menendez-Montes I, Thet S, Elhelaly WM, Xiao F, Wang X, Williams NS, Canseco DC, Red-Horse K, Rothermel BA, Sadek HA. Targeting calcineurin induces cardiomyocyte proliferation in adult mice. Nature Cardiovascular Research (2022) 1:679-688
    Menendez-Montes I, Abdisalaam S, Xiao F, Lam NT, Mukherjee S, Szweda LI, Asaithamby A, Sadek HA. Mitochondrial fatty acid utilization increases chromatin oxidative stress in cardiomyocytes. Proc Natl Acad Sci U S A (2021) 118:e2101674118
    Nguyen NUN, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WLW, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA. A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes. Nature (2020) 582:271-276
    Muralidhar SA, Sadek HA. Meis1 Regulates Postnatal Cardiomyocyte Cell Cycle Arrest. In: Nakanishi, T., Markwald, R., Baldwin, H., Keller, B., Srivastava, D., Yamagishi, H. (eds) Etiology and Morphogenesis of Congenital Heart Disease. Springer, Tokyo. (2016) Jun 25 [Epub ahead of print]
    Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. Transient regenerative potential of the neonatal mouse heart. Science (2011) 331:1078-80

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